The ambient-temperature ortho C-H arylation of electron-deficient benzoic acids with aryl iodides has been achieved by using an Ac-Ile-OH-supported Pd catalyst. A wide range unactivated could cross-couple array in moderate to excellent yields. choice HFIP as a solvent is crucial realizing the mild arylation, and beneficial effect ligand on reaction likely stems from accelerated activation process improved catalyst lifetime.

Phthalide skeletons have been synthesized for the first time through a Rh(III) -catalyzed C-H olefination of benzoic acids under mild conditions using oxygen as sole oxidant. Aromatic bearing variety functional groups could react with diverse alkenes to afford desired cyclized lactones or uncyclized alkenylarenes in moderate-to-excellent yields.

The construction of C(sp3)–N bonds via direct radical–radical cross-coupling under benign conditions is a desirable but challenging approach. Herein, the alkyl and amidyl radicals to build aliphatic C–N in concise, mild, oxidant-free manner implemented by nickel/photoredox dual catalysis. In this protocol, single electron transfer strategy successfully employed generate N- C-centered from sulfonyl azides/azidoformates alkyltrifluoroborates, respectively. photocatalyst-induced triplet–triplet...

Hydrogen sulfide (H2S), an endogenous signaling molecule, is known to play a pivotal role in neuroprotection, vasodilation, and hormonal regulation. To further explore the biological effects of H2S, refined donors that facilitate its delivery, especially under specific (patho) physiological conditions, are needed. In present study, we demonstrate ortho-substituted, aryl boronate esters provide two unique distinct pathways for H2S release from thioamide-based donors: Lewis acid-facilitated...

In recent years, amination of alkylboronates through ionic copper catalysis or boron-ate complex 1,2-metalation has been well established, but complementary radical processes remain less studied before. Herein, based on rational design, we develop several imine-type N-centered scavengers and apply them to the alkylboronates. The reaction proceeds under mild photoredox-catalyzed transition-metal-free conditions features excellent functional group tolerance. It also enables preparation a range...

Hydrogen sulfide (H

Summary of main observation and conclusion It could be proposed that gold(I)‐catalyzed reactions ynamides with benzofurazan N‐oxides might proceed through either O ‐attack or N to afford α‐oxo α‐imino Au(I)‐carbenoid intermediates. Computational studies were performed predict are ready undergo the chemoselective Au(I)‐activated generate intermediate. Experimental carried out confirm computational results 7‐nitroindole derivatives synthesized in a concise efficient manner. The unfavored for...

An efficient and novel approach to accessing 3-selenylquinolines from diaryl diselenides acyclic, selenium-free substrates is described. Preliminary mechanistic studies indicate that the combination of CuCl2 air affords an appropriate environment for producing arylselenyl radicals initiate cascade cyclization N-(2-alkynyl)anilines, forming key Se–C C–C bonds in a single step. Using this chemistry, wide variety were produced moderate excellent yield under mild conditions, highlighting...

Like hydrogen sulfide (H 2 S), its chalcogen congener, selenide Se), is an emerging biomolecule of interest. Therefore, small molecule donors that effectively increase bioavailability are desired to further probe H Se chemical biology.

Small and medium sized enterprises (SMEs) have been playing more important roles in modern economy. However, only a little attention has paid to the SME oriented supply chain management research. Purchasing is one of most components management. To profit from cooperative purchasing, this paper proposes multi-agent system (MAS), which constructs coordinates purchasing consortium. And structure MAS outline negotiation process are illustrated detail. A modified aggregation algorithm based on...

An unprecedented silver-catalyzed desulfurizative annulation of 1,2-benzisothiazoles with ynamides to access multi-substituted isoquinoline derivatives is disclosed.

A visible-light-promoted S -alkylation of 1,2,3-thiadiazoles with C-radical precursors, 4-alkyl-1,4-dihydropyridines (DHPs), to produce alkenyl thioethers is disclosed.

The synthesis of carbazoles via Pd-catalyzed direct cross-coupling indoles with in situ generated aryl vinyl ketones by using statured as the olefins source is described. This protocol obviates need for additional preparation steps and therefore opens up a new door to an atom-and step-economical fashion.

Abstract Aromatic acids with various functional groups react a range of alkenes affording cyclized lactones or uncyclized alkenylarenes.