A5007662882- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Machine Learning in Materials Science
- Advanced Biosensing Techniques and Applications
- Anodic Oxide Films and Nanostructures
- RNA and protein synthesis mechanisms
- Microfluidic and Capillary Electrophoresis Applications
Micron (United States)
2020-2023
Boise State University
2020-2023
DNA strand displacement networks are a critical part of dynamic nanotechnology and proven primitives for implementing chemical reaction networks. Precise kinetic control these is important their use in range applications. Among the better understood widely leveraged properties toehold sequence, length, composition, location. While steric hindrance has been recognized as an factor such systems, clear understanding its impact role lacking. Here, systematic investigation within toehold-mediated...
DNA-based circuits and computational tools offer great potential for advanced biomedical technological applications. However, leakage, which is the production of an output in absence input, widely exists DNA network. As a new approach to leakage reduction, this study utilizes availability reduce entropy-driven autocatalytic reaction networks. Here, we report performance improvements resulting from direct tailoring fuel strand through two novel approaches: (1) addition interfering domains...
Biosensing using aptamers has been a recent interest for their versatility in detecting many different analytes across wide range of applications, including medical and environmental applications. In our last work, we introduced customizable aptamer transducer (AT) that could successfully feed-forward output domains to target variety reporters amplification reaction networks. this paper, explore the kinetic behavior performance novel ATs by modifying complementary element (ACE) chosen based...
Solution-based biosensors that utilize aptamers have been engineered in a variety of formats to detect range analytes for both medical and environmental applications. However, since fixed base sequences, incorporation into DNA strand displacement networks feed-forward signal amplification processing requires significant redesign downstream reaction networks. We designed novel aptamer transduction network releases customizable output domains, which can then be used initiate without any...