A5008578156- Antioxidant Activity and Oxidative Stress
- Free Radicals and Antioxidants
- Mesenchymal stem cell research
- Algal biology and biofuel production
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Vitamin C and Antioxidants Research
- Autophagy in Disease and Therapy
- Textile materials and evaluations
- Polymer crystallization and properties
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Corrosion Behavior and Inhibition
- Knee injuries and reconstruction techniques
- Saffron Plant Research Studies
- Advancements in Transdermal Drug Delivery
- Surface Modification and Superhydrophobicity
- Polymer Science and PVC
- Cellular Mechanics and Interactions
- Proteoglycans and glycosaminoglycans research
- Concrete Corrosion and Durability
- Bee Products Chemical Analysis
- Hydrogels: synthesis, properties, applications
- Medicinal Plants and Bioactive Compounds
- Magnesium Alloys: Properties and Applications
Laboratoire de Recherche Vasculaire Translationnelle
2015-2025
Inserm
2015-2025
Université Sorbonne Paris Nord
2015-2025
Sorbonne Université
2019-2025
Université Paris Cité
2010-2020
Sorbonne Paris Cité
2015-2020
Hôpital Xavier Arnozan
2011
University of Washington
2006-2007
École nationale supérieure d'arts et métiers
1994-2002
École Nationale Supérieure des Arts et Industries Textiles
2001-2002
Astaxanthin, a powerful antioxidant, is good candidate for the prevention of intracellular oxidative stress. The aim study was to compare antioxidant activity astaxanthin present in two natural extracts from Haematococcus pluvialis, microalgae strain, with that synthetic astaxanthin. Natural were obtained either by solvent or supercritical extraction methods. UV, HPLC-DAD and (HPLC-(atmospheric pressure chemical ionization (APCI)+)/ion trap-MS) characterizations both showed similar...
Astaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing treating oxidative stress-related pathologies. However, its high lipophilicity thermolability often limits antioxidant efficacy human applications. Here, we developed formulation lipid carriers to protect astaxanthin’s activity. The synthesis natural astaxanthin-loaded nanostructured using green process with sunflower oil as...
Abstract Mechanistic schemes of radical oxidation hydrocarbon polymers in which initiation is only due to unimolecular or bimolecular hydroperoxide decomposition have been studied. The results their kinetic analysis compared with literature data relative the thermal polypropylene solid state (60‐160°C). These are remarkably good agreement “unimolecular” scheme whose main characteristics are: (1) quasi‐independence behavior initial conditions (for low content thermolabile structures), and (2)...
This work focuses on the development and evaluation of a dual nanostructured lipid carrier (NLC)/Carbopol®-based hydrogel system as potential transporter for topical delivery curcumin to skin. Two populations different sized negatively charged NLCs (P1, 70–90 nm P2, 300–350 nm) were prepared characterized by means dynamic light scattering. presented an ovoid platelet shape confirmed transmission electron microscopy techniques. Curcumin NLC entrapment efficiency release profiles assessed HPLC...
The grafting of poly(sodium styrene sulfonate) (pNaSS) onto ozone-treated poly(ethylene terephthalate) (PET) fabric surfaces was characterized by X-ray photoelectron spectroscopy and toluidine blue colorimetry. Significant amounts pNaSS were grafted over the range experimental conditions examined in this study (30−120 min ozonation, reaction at 65 or 70 °C, times up to 240 min). Within these ranges amount increased with both ozonation time temperature. first 60 reaction, then remained...
It was previously reported that crocin, a water-soluble carotenoid isolated from the
The purpose of this study is to develop a reliable method functionalizing poly(ethylene terephthalate) with bioactive polymers produce "biointegrable" artificial anterior cruciate ligament. Radical graft polymerization the sodium salt styrene sulfonate (NaSS) onto (PET) films was performed using "grafting from" technique. Prior grafting, surfaces were activated by ozonation generate peroxide and hydroperoxide reactive species on PET film surfaces. radical NaSS initiated thermal decomposition...
After myocardial infarction, the heart's mechanical properties and its intrinsic capability to recover are compromised. To improve this recovery, several groups have developed cardiac patches based on different biomaterials strategies. Here, we polyvinylalcohol/dextran (PVA/Dex) elastic hydrogel patches, obtained through freeze thawing (FT) process, with aim deliver locally a potent natural antioxidant molecule, astaxanthin, assist response against generated myofibril stress. Extensive...
An imbalance in the reactive oxygen species (ROS) homeostasis is involved pathogenesis of oxidative stress‐related diseases. Astaxanthin, a xanthophyll carotenoid with high antioxidant capacities, has been shown to prevent first stages stress. Here, we evaluate capacities astaxanthin included within hydroxypropyl‐beta‐cyclodextrin (CD‐A) directly and indirectly reduce induced ROS production. First, chemical methods were used corroborate preservation abilities after inclusion. Next,...
(1) Background: Reperfusion injury refers to the cell and tissue damage induced, when blood flow is restored after an ischemic period. While reperfusion reestablishes oxygen supply, it generates a high concentration of radicals, resulting in dysfunction damage. Here, we aimed challenge achieve potential delivery system based on astaxanthin, natural antioxidant, attenuating muscle animal model femoral hind-limb ischemia reperfusion. (2) Methods: The antioxidant capacity non-toxicity...
Abstract The cell therapy of damaged tissue, which is linked to hypoxia condition might fail, in large part due the emergence oxidative stress (OS) and/or mitochondrial dysfunctions. Thus, invigoration stem cells against could be a reliable strategy improve outcome. Of various antioxidants, mito‐Tempo (mito‐T) one potent antioxidants that target and neutralize stress. In this study, for induction mitochondria mesenchymal (MSCs) isolated from human adipose antimycin A (AMA) was used then...
The aim of the present study was to achieve immobilization dermatan sulfate (DS) on polyethylene terephthalate (PET) surfaces and evaluate its biocompatibility. DS obtained from skin Scyliorhinus canicula shark immobilized via carbodiimide knitted PET fabrics, modified with carboxyl groups. PET-DS characterization performed by SEM, ATR-FTIR contact angle measurements. Biocompatibility evaluated investigating plasma protein adsorption endothelial cell proliferation, as well subcutaneous...
Natural antioxidants, such as astaxanthin (AX), resveratrol (RV) and curcumin (CU), are bioactive molecules that show a number of therapeutic effects. However, their applications remarkably limited by poor water solubility, physico-chemical instability low bioavailability. In the present work, it is shown self-assembled hyaluronan (HA)-based nanohydrogels (NHs) taken up endothelial cells (Human Umbilical Vein Endothelial Cells, HUVECs), preferentially accumulating in perinuclear area...
The anterior cruciate ligament (ACL) is the most important for knee stabilization. Unfortunately, it also commonly injured. Synthetic polymers such as polyethylene terephthalate (PET) are widely used to fabricate prostheses. In this study, we reported how graft poly(sodium styrene sulfonate) (pNaSS) onto PET fabrics prepare at a rate of about 4.5 times 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> mol/g. analyzed morphology human...