A5061642239- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Allergic Rhinitis and Sensitization
- Nail Diseases and Treatments
- Advancements in Transdermal Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Skin and Cellular Biology Research
- Sphingolipid Metabolism and Signaling
- Immunotherapy and Immune Responses
- Antimicrobial Peptides and Activities
- Lymphoma Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
- Biochemical and Structural Characterization
Leiden University
2024
Centre for Human Drug Research
2023-2024
University of Freiburg
2022
Tolaasin II is an amphiphilic, membrane-active, cyclic lipopeptide produced by Pseudomonas tolaasii and responsible for brown blotch disease in mushroom. To better understand the mode of action membrane selectivity tolaasin related lipopeptides, its permeabilizing effect on liposomes different thickness was characterized. An equi-activity analysis served to distinguish between effects partitioning intrinsic activity membrane-bound peptide. It found that thicker membranes require higher local...
ABSTRACT Psoriasis is an inflammatory skin disease associated with impaired barrier. The barrier function dependent on the extracellular lipid matrix which surrounds corneocytes in stratum corneum. Ceramides comprise essential components of this matrix. Alterations corneum ceramide profile have been directly linked to dysfunction and might be underlying factor impairment psoriasis. In study, we investigated Lesional non‐lesional 26 patients 10 healthy controls were analysed using in‐depth...