A5082968177- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Ocular Surface and Contact Lens
- Parkinson's Disease and Spinal Disorders
- Pathogenesis and Treatment of Hiccups
- Hemispheric Asymmetry in Neuroscience
- Amino Acid Enzymes and Metabolism
- Advanced Glycation End Products research
- Neural dynamics and brain function
- Peripheral Neuropathies and Disorders
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Salivary Gland Disorders and Functions
- EEG and Brain-Computer Interfaces
- Hereditary Neurological Disorders
- Retinal Development and Disorders
- Nuclear Receptors and Signaling
- Alcoholism and Thiamine Deficiency
Sechenov University
2015-2024
Pirogov Russian National Research Medical University
2018-2022
Ministry of Health of the Russian Federation
2018-2022
ORCID
2022
Parkinson's disease (PD) is diagnosed many years after its onset, under a significant degradation of the nigrostriatal dopaminergic system, responsible for regulation motor function. This explains low effectiveness treatment patients. Therefore, one highest priorities in neurology development early (preclinical) diagnosis PD. The aim this study was to search changes blood patients at risk developing PD, which are considered potential diagnostic biomarkers. Out 1835 patients, 26 were included...
Parkinson’s disease (PD) is diagnosed by the onset of motor symptoms and treated long after its onset. Therefore, development early diagnosis PD a priority for neurology. Advanced methodologies this include (1) searching patients at risk developing prodromal based on premotor symptoms; (2) changes in body fluids these as diagnostic biomarkers; (3) verifying diagnostic-value biomarkers using positron emission tomography (PET); (4) anticipating symptoms. According to our data, majority (n =...
An important approach to an early diagnosis of Parkinson's disease (PD) is screening for peripheral biomarkers in patients at the clinical stage. In this study, we evaluated catecholamine concentration changes tear fluid untreated PD as biomarkers. Norepinephrine and dopamine concentrations were found increase compared those age controls, which was especially pronounced on side where motor symptoms appeared. On contrary, epinephrine reduced bilaterally. Since there no reason consider markers...
Development of differential and early (preclinical) diagnostics Parkinson’s disease (PD) is among the priorities in neuroscience. We searched for changes level catecholamines α-2-macroglobulin activity tear fluid (TF) PD patients at an clinical stage. It was shown that TF characterized by increased noradrenaline mainly on ipsilateral side pronounced motor symptoms (72%, p = 0.049), a decreased adrenaline both sides (ipsilateral—53%, 0.004; contralateral—42%, 0.02), 0.03; contralateral—56%,...
Background. The promising approach to Parkinson’s disease study in order increase the therapeutic effectiveness is update symptoms that can affect quality of life. impact neuropsychiatric (NPS) on different aspects life at stages not studied. Purpose: assess NPS PD. Patients and methods: One hundred eighty eight (188) patients with without dementia (95 males 93 females) 1–4 were examined. mean age was 63,84±0,6 years, stage 2,6±0,3, PD duration consisted 6,3±4,1 years. We used following...
OBJECTIVES: The impact of sleep disorders on quality life patients with Parkinson’s disease (PD) is underestimated. significant role in the pathophysiology belongs to neurodegeneration brain systems that regulate sleep-wake cycle and motor, affective, sensor urine disorders. PURPOSE OF STUDY: assess prevalence insomnia, its connection neuropsychological disturbances different stages (PD). PATIENTS AND METHODS: One hundred eighty eight (188) (95 females 93 males) without dementia were...
OBJECTIVES: The clinical relevance of hypersomnia in patients with Parkinson’s disease (PD) is underestimated. It manifests constant excessive daytime somnolence and short-term sleep attacks. relation insomnia the impact on quality life are not studied. PURPOSE OF STUDY: to assess prevalence demographic outcomes hypersomnia, its motor, neuropsychological disturbances patients. PATIENTS AND METHODS: One hundred six (106) without dementia were examined. mean age was 63,78±0,6 years, stage...
The main treatment for cervical dystonia (CD) is botulinum toxin type A (BTA) injections, but several long-term studies have found that between 19-46% of patients discontinue treatment. Anxiety and depression play a signi fi cant role in reducing the quality life with CD, according to previous surveys. Aim: assess dynamics CD symptom severity, emotional disturbance, under different methods. Material 61 16 (26%) men 45 (74%) women, age 50 [40; 59] years, duration illness 4 [2; 7] at onset 44...
This review provides information onthe non-motor peripheral manifestations of Parkinsons disease (PD) associated with a pathology the visual analyzer and auxiliary apparatus eye. The relationship between neurodegenerative processes that take place in brain eye opens new prospects to use preventive ophthalmologic examination todiagnose PD long before characteristic motor symptoms appear. will encourage neuroprotective therapy, which stops, or at least slows down, neuronal death, instead...
Cervical dystonia (CD) has a wide range of non-motor (neuropsychiatric, sensory, dyssomnic) disorders. Relationships between dystonia, nonmotor manifestations the disease and patients quality life (QoL) require clarification. Objective: to clarify impact affective, behavioral disorders, sleep wakefulness on with CD. Patients methods. We examined 61 CD (mean age – 48.03±11.49 years, mean duration 4.89±4.05 years). used Toronto Western Hospital Spasmodic Torticollis Rating Scale (TWSTRS),...
Non-motor disturbances represented by sensory, affective, obsessive-compulsive disorders, cognitive dysfunction, sleep are often found in patients with dystonia and have a negative impact on their quality of life. The prevalence sensory affective disorders is above 50% cervical 25% blepharospasm, writing spasm; dysfunction more than focal dystonia. relationship non-motor, particular psychiatric the impairment social everyday life worsening whole was shown. Common pathophysiological...
The article presents the current criteria for clinically reliable and possible Parkinson's disease; role of paraclinical methods in diagnosis is discussed.
REM-sleep behavior disorder (RBD), a form of parasomnia, is characterized by motor and/or speech activity during sleep corresponding to the dream content. RBD currently considered as marker onset neurodegenerative diseases (sinucleinopathies) and most specific early symptom Parkinson's disease (PD). The authors describe clinical case patient with combination essential tremor, initial signs PD RBD. A polysomnographic study has confirmed determined disturbances architecture: increase in...
A decrease in the quality of life (QoL) cervical dystonia (CD) is often due to anxiety and depressive manifestations. However, change emotional state patients with CD after botulinum therapy has not been studied enough. Objective : a comparative analysis severity disorders their dynamics during year movement therapy. Patients methods . 25 (9 men 16 women) healthy volunteers (11 14 were examined. The was assessed using Tsui Rating Scale. To assess level anxiety, GAD-7 scales used, depression...
Daytime sleepiness is one of the clinically significant non-motor manifestations Parkinson's disease (PD). One its insufficiently studied aspects a relationship between daytime and nighttime sleep disorders. Objective: to clarify clinical characteristics PD in patients with different types estimate ratio polysomnographic advanced stages PD. Patients methods . The investigation included 110 (56 men 54 women) (mean age, 63.78+0.6 years) (Hoehn Yahr stage 2.6+0.2; duration, 6.3+3.2 without...
Parasomnia, a syndrome of rapid eye movement sleep behavior disorder (RBD), is common non-motor impairment in patients with Parkinson's disease (PD). The relationship between RBD other symptoms PD affecting night sleep, particular, nocturia, understudied. An aim the study was to determine related disturbances and assess dynamics these progression taking into account onset.One hundred forty (72 male 68 female) without dementia (mean age 61.98±0.79 years, stage - 2.35±0.05, duration 5.82±90.65...
Botulinum toxin injection therapy is the mainstay for managing patients with motor manifestations of dystonia. It important to identify possible cognitive and mental disorders, sleep perceptual disorders (non-motor disorders) in these patients. Correction will be able optimize treatment improve quality life
Background: depression along with cognitive impairment is one of the most common non-motor psychopathological symptom Parkinson's disease (PD), however, problem nosological differentiation and typology affective disorders in PD still unresolved. The goal: this study investigation determination mode association between neurological disorders. Patients methods : research was conducted at Clinic Nervous Diseases named after A.Ya. Kozhevnikov I.M. Sechenov First Moscow State Medical University...
Excessive daytime sleepiness (hypersomnia) is one of the clinically important, but inadequately studied symptoms Parkinson’s disease (PD). It manifests as constant excessive during day and/or short unexpected (unintentional) naps. Hypersomnia negatively affects quality life in patients; it potentially dangerous situations requiring greater attention. The paper presents current approaches to diagnosing hypersomnia PD. discusses multifactorial nature its pathophysiology patients with...
The paper summarizes the literature and author's data on development of early (preclinical) diagnosis Parkinson's disease (PD). Implementation this will promote use preventive therapy change investments in treatment patients. declares that at present only approach to PD is positron-emission tomography nigrostriatal dopaminergic system, but it cannot be used for examination due its high cost. authors consider a less specific, more promising search markers body fluids, mainly blood, patients...
Nocturnal sleep disorders are one of the most important non-motor manifestations Parkinson’s disease (PD). The clinical significance in PD is determined by their frequency (up to 88%) and negative impact on quality life patients. paper presents spectrum PD, current approaches diagnosis. It discusses multifactorial nature pathophysiology these disorders. Current views relationship neurodegeneration brain structures involved regulation wakefulness, circadian therapy depicted. On basis...
Sudden-onset sleep (SOS) is one of the manifestations excessive daytime sleepiness (ЕDS) in Parkinson’s disease (PD). Aim: сlarify clinical and polysomnographic characteristics patients with SOS at expanded (2 3 stages according to Hoehn–Yahr) PD. Material methods. 42 (18 men 24 women, average age 66.5 ± 7.9 years, duration PD 8.9 4.6 Hoehn–Yahr stage 2.6 0.5) who received combined dopaminergic therapy levodopa dopamine agonist were examined. 32 had ЕDS, 10 did not have it. The Unified...