A5041653659- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Curcumin's Biomedical Applications
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- interferon and immune responses
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Pharmacological Effects of Medicinal Plants
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Cancer-related gene regulation
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- Bone Metabolism and Diseases
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Electrospun Nanofibers in Biomedical Applications
- Acute Myeloid Leukemia Research
- Synthesis and bioactivity of alkaloids
- vaccines and immunoinformatics approaches
Indian Institute of Science Education and Research, Bhopal
2025
The Wistar Institute
2020-2024
Indian Institute of Technology Guwahati
2015-2022
Holy Cross University
2021
Jan Kochanowski University
2021
Memorial University of Newfoundland
2015
Oral cancer is a major public health burden worldwide. The lack of biomarkers for early diagnosis has increased the difficulty in managing this disease. Recent studies have reported that neutrophil gelatinase-associated lipocalin (NGAL), secreted glycoprotein, upregulated various tumors. In our study, we found NGAL was significantly downregulated primary malignant and metastatic tissues oral comparison to normal tissues. downregulation strongly correlated with both degree differentiation...
Ovarian cancer (OC) is a lethal gynecologic malignancy, with modest responses to CPI. Engagement of additional immune arms, such as NK cells, may be value. We focused on Siglec-7 surface antigen for engaging this population. Human antibodies against were developed and characterized. Coculture OC cells PBMCs/NKs binding showed NK-mediated killing lines. Anti-Siglec-7 mAb (DB7.2) enhanced survival in OC-challenged mice. In addition, the combination DB7.2 anti-PD-1 demonstrated further improved...
Background: Oral squamous cell carcinoma (OSCC) is one of the most predominant cancers in India. With advances field oncology, a number therapies have emerged; however, they are minimally effective. Consequently, there need to develop safe and effective regimens for treatment OSCC. Butein, tetrahydroxychalcone has been found exhibit potent antioxidant, anti-inflammatory, also anti-tumor effects against several cancer types. However, its effect on OSCC not studied yet. Methods: The butein...