Danna Sheinboim
A5047768652- Advanced Radiotherapy Techniques
- Sarcoma Diagnosis and Treatment
- melanin and skin pigmentation
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- RNA Research and Splicing
- Cancer Research and Treatments
- Plant Molecular Biology Research
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
Tel Aviv University
2016-2022
Abstract MicroRNA (miRNA) biogenesis initiates co-transcriptionally, but how the Microprocessor machinery pinpoints locations of short precursor miRNA sequences within long flanking regions transcript is not known. Here we show that depends on DNA methylation. When coding sequence are highly methylated, miRNAs more expressed, have greater conservation, and likely to drive cancer-related phenotypes than encoded by unmethylated loci. We removal methylation from loci leads their downregulation....
During development, enhancers play pivotal roles in regulating gene expression programs; however, their involvement cancer progression has not been fully characterized. We performed an integrative analysis of DNA methylation, RNA-seq, and small RNA-seq profiles from thousands patients, including 25 diverse primary malignances seven body sites metastatic melanoma. found that are consistently the most differentially methylated regions (DMR) as progresses normal to tumors then metastases,...
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind this relationship remains mostly unknown. Here we report that exercise induces metabolic reprogramming of internal organs increases nutrient demand protects against metastatic colonization by limiting availability to tumor, generating an exercise-induced shield. Proteomic ex vivo capacity analyses murine revealed catabolic processes, glucose uptake, mitochondrial activity, GLUT expression. analysis...
Skin sun exposure induces two protection programs: stress responses and pigmentation, the former within minutes latter only hours afterward. Although serving same physiological purpose, it is not known whether how these programs are coordinated. Here, we report that UVB every other day significantly more skin pigmentation than higher frequency of daily exposure, without an associated increase in responses. Using mathematical modeling empirical studies, show melanocyte master regulator, MITF,...
Fat cells secrete cytokines that enhance pro-metastatic TGF-β signaling in melanoma cells.
Abstract Ectopic expression of lineage master regulators induces transdifferentiation. Whether cell fate transitions can be induced during various developmental stages has not been systemically examined. Here we discover that amongst different stages, mouse embryonic stem cells (mESCs) are resistant to conversion by the melanocyte regulator MITF. By generating a transgenic system exhibit in mESCs, pluripotency Oct4, counteracts pro-differentiation Mitf physical interference with MITF...
<div>Abstract<p>Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind this relationship remains mostly unknown. Here we report that exercise induces metabolic reprogramming of internal organs increases nutrient demand protects against metastatic colonization by limiting availability to tumor, generating an exercise-induced shield. Proteomic <i>ex vivo</i> capacity analyses murine revealed catabolic processes, glucose uptake,...
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Supplementary Data from An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination