A5010328979- Fuel Cells and Related Materials
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Membrane-based Ion Separation Techniques
- Nutrition, Genetics, and Disease
- Cancer Cells and Metastasis
- Advancements in Solid Oxide Fuel Cells
- Head and Neck Cancer Studies
- DNA Repair Mechanisms
- Pediatric health and respiratory diseases
- Breast Cancer Treatment Studies
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Membrane Separation Technologies
- Ionic liquids properties and applications
- Conducting polymers and applications
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
Ministry of Health of the Russian Federation
2022-2024
Irkutsk National Research Technical University
2017-2019
Актуальность. Установлено, что несмотря на инфильтрацию опухоли иммунокомпетентными клетками, зачастую плоскоклеточный рак головы шеи (ПРГШ) демонстрирует именно иммуносупрессивный тип микроокружения, влияет результаты лечения и диктует поиск новых прогностических маркеров мишеней терапии. Цель исследования. Изучить состав иммунных клеток при орофарингеальном плоскоклеточном раке (ОФПКР) экспрессии PD-L1 (CPS, TPS) в зависимости от ВПЧ-статуса, пола возраста. Материалы методы. В исследование...
Background . Data on the prognostic role of PIK3CA mutation in hormone receptor-positive (HR+) HER2-negative (HER2–) breast cancer (BC) are contradictory; nevertheless, there indications its negative predictive and significance. This dictates need for early genetic testing BC to predict clinical course, select a primary therapy option individualize systemic treatment with disease progression. Investigation regulation tumor cell cycle, as well relationship between markers, infiltration...
Introduction. Cigarette smoking along with alcohol consumption, infection human papilloma (HPV) and the Epstein–Barr viruses, is one of main risk factors for head neck squamous cell carcinoma. It can also contribute to virus-associated carcinogenesis affect clinical prognostic features tumor. Continued at diagnosis carcinoma a negative factor contributes reduced patient survival rates. Aim. To analyze status effect etiopathogenesis on molecular in patients oropharyngeal (OpSCC). Materials...
Impregnation of an industrial dielectric polyethylene terephthalate film having through-track micropores with new phosphorus-containing proton-conducting ionic liquids allows the electrical conductivity this to be increased by 7–8 orders magnitude. The plasma-radiation curing vinyl liquid leads formation a proticinterpolymer composite in track holes film.
Background . It is suggested that defects in BRCA1 / 2 genes contribute to a high mutational load and immunogenicity, which modulates immune microenvironment. At the same time, it was shown -associated breast cancer tumors do not belong category of immunoactive ones. These have low expression response exhibit an immunosuppressive type This indicates need antitumor modulation maintaining optimal balance tumor CD4/CD8 T-lymphocytes ratio. In addition, there evidence additional evaluation TP53...
This study is devoted to the development and investigation of composite membrane materials for fuel cells. Proton conductive membranes consisting silica various low- high-molecular organic compounds have been prepared by sol-gel method. The synthesized are characterized proton conductivity (up 10-2 S/cm), ion-exchange capacity (1.84-3.5 meq/g), thermal stability (260 – 400 °C), tensile modulus (128 - 322 MPa).
Background . Currently, there is growth evidence on prognostic and clinical differences in breast cancer (BC) associated with different types of BRCA1 / 2 mutations. At the same time, a triple negative tumor phenotype not an absolute pathognomonic sign -associated cancer, where luminal phenotypes are being detected increasingly. In addition, attention paid to significance estrogen signaling mechanism depending surrogate type, including due alternative mechanisms. Objective : evaluate 2-...