A5051595832- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA modifications and cancer
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Bioinformatics and Genomic Networks
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- BRCA gene mutations in cancer
- Tryptophan and brain disorders
- Endometrial and Cervical Cancer Treatments
- Bone Tissue Engineering Materials
- Brain Metastases and Treatment
- Nerve injury and regeneration
- Cancer Mechanisms and Therapy
- Advanced Nanomaterials in Catalysis
- Carcinogens and Genotoxicity Assessment
- Folate and B Vitamins Research
- Phytochemical compounds biological activities
- Chromatin Remodeling and Cancer
Shahid Beheshti University of Medical Sciences
2018-2025
University of Illinois Chicago
2018
Isfahan University of Medical Sciences
2014-2016
In this study, we aimed to determine the prevalence of human papillomavirus (HPV) in ovarian endometriosis and tissue from women without endometriosis. Understanding pathogenesis disease could help us design preventative strategies as well novel appropriate treatment approaches regard.In cross-sectional formalin-fixed paraffin-embedded sections 50 49 ovaries with endometriosis, respectively, were evaluated for presence high-risk HPV using polymerase chain reaction technique. Prevalence...
Long non-coding RNAs (lncRNAs) have prominent roles in the pathogenesis of human cancers. Several studies shown oncogenic or tumor suppressor lncRNAs different tissues. Thus, these transcripts been regarded as putative targets treatment cancer. The lncRNA terminal differentiation-induced RNA (TINCR) has an especial position this regard, it exerts opposite While is up-regulated gastric, esophageal, bladder and breast cancer; down-regulated glioma, retinoblastoma prostate Notably, data...
Abstract Mitogen-activated protein kinase (MAP kinase) pathways participate in regulation of several cellular processes involved breast carcinogenesis. A number non-coding RNAs including both microRNAs (miRNAs) and long (lncRNAs) regulate or being regulated by MAPKs. We performed an in-silico method for identification MAPKs with high interactions miRNAs lncRNAs. Bioinformatics approaches revealed that MAPK14 ranked first among Subsequently, we identified lncRNAs were predicted to be...
Abstract Breast cancer is a highly heterogeneous disorder characterized by dysregulation of expression numerous genes and cascades. In the current study, we aim to use system biology strategy identify key signaling pathways in breast cancer. We have retrieved data two microarray datasets (GSE65194 GSE45827) from NCBI Gene Expression Omnibus database. R package was used for identification differentially expressed (DEGs), assessment gene ontology pathway enrichment evaluation. The DEGs were...
Abstract The mechanistic target of rapamycin (mTOR) is a fundamental component signaling pathway that involved in the pathogenesis breast cancer via different mechanisms. This functionally linked with number small nucleolar RNA host genes ( SNHG s). In present project, we have searched for expression quantitative trait loci (eQTLs) within s are possibly cancer. Following this silico step, assessed levels mTOR and four malignant nonmalignant samples obtained from 80 patients We also genotyped...
BACKGROUND: Several recent studies have assessed suitability of tumor antigens for immunotherapy. Based on the restricted expression pattern in somatic tissues, cancer-testis (CTAs) are possible candidates cancer These expressed various tumors including g astrointestinal, breast, skin and hematologic malignancies. OBJECTIVES: To find clinical trials utilizing CTAs patients. METHODS: We searched PubMed, google scholar specific websites that registers trials. RESULTS: A number been designed to...
BACKGROUND: Recent studies have highlighted the role of natural elements in reduction cancer cell growth and apoptosis. Koenimbine, a product isolated from Murraya koenigii (L) Spreng is substance with cytotoxic effects on cells. AIM: The koenimbine HT-29 SW48 colon cells were evaluated by MTT Annexin V assays. Expression levels Wnt/β-catenin pathway genes quantified real time PCR. RESULTS: IC50 values was calculated to be 50 μg/ml based results assay. This value 75 IEC-18 which used as...