A5019125110- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Nutrition, Genetics, and Disease
- Retinal Development and Disorders
- RNA modifications and cancer
- Protein Kinase Regulation and GTPase Signaling
- Genetic Neurodegenerative Diseases
- Vector-borne infectious diseases
- Biochemical and Structural Characterization
- South Asian Cinema and Culture
- Genomic variations and chromosomal abnormalities
- Chromosomal and Genetic Variations
- Mitochondrial Function and Pathology
- Salivary Gland Disorders and Functions
- Oral health in cancer treatment
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Insect symbiosis and bacterial influences
- Prenatal Screening and Diagnostics
Baylor College of Medicine
2018-2022
The University of Texas MD Anderson Cancer Center
2015-2022
Texas Children's Hospital
2018
Neurological Research Institute
2018
Genomics (United Kingdom)
2016
Texas A&M University
2011
Incidence of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing dramatically. Although long-term survival rates for these patients are high, they often suffer from permanent radiotherapy-related morbidity. This prompted the development de-escalation clinical protocols to reduce However, a subset do not respond even standard therapy and have poor outcomes. It is unclear how properly identify treat high- low-risk OPSCC patients. Since HPV positivity drives radiotherapy...
Caspase-8 (CASP8) is one of the most frequently mutated genes in head and neck squamous carcinomas (HNSCCs), CASP8 mutations are associated with poor survival. The distribution these HNSCCs suggests that they likely to be inactivating. Inhibition has been reported sensitize cancer cells necroptosis, a regulated cell death mechanism. Here, we show knockdown renders susceptible necroptosis by second mitochondria-derived activator caspase (SMAC) mimetic, birinapant, combination pan-caspase...
Recently, increased number of studies have demonstrated a relationship between the oral microbiome and development head neck cancer, however, there are few to investigate role bacteria in context tumor microenvironment single subsite. Here, paired adjacent normal tissues from thirty-seven tongue squamous cell carcinoma (SCC) patients were subjected 16S rRNA gene sequencing whole exome (WES), addition RNA for samples. We observed that Fusobacterium was significantly enriched cancer Rothia...
Dendritic arbor architecture profoundly impacts neuronal connectivity and function, aberrant dendritic morphology characterizes neuropsychiatric disorders. Here, we identify the adhesion-GPCR BAI1 as an important regulator of arborization. loss from mouse or rat hippocampal neurons causes hypertrophy, whereas overexpression precipitates dendrite retraction. These defects specifically manifest dendrites transition growth to stability. BAI1-mediated arrest is independent its Rac1-dependent...
Synaptic connections between neurons are essential for every facet of human cognition and thus regulated with extreme precision. Rho-family GTPases, molecular switches that cycle an active GTP-bound state inactive GDP-bound state, comprise a critical feature synaptic regulation. Rho-GTPases exquisitely controlled by extensive suite activators (GEFs) inhibitors (GAPs GDIs) interact many different signalling pathways to fulfill their roles in orchestrating the development, maintenance,...
Germline copy-number variants (CNVs) involving quadruplications are rare and the mechanisms generating them largely unknown. Previously, we reported a 20-week gestation fetus with split-hand malformation; clinical microarray detected two maternally inherited triplications separated by neutral region at 17p13.3, BHLHA9 part of YWHAE. Here, describe an 18-month-old male sibling previously described malformation. Custom high-density digital droplet PCR revealed gains were actually in mother,...
Abstract Determining which HPV+ oropharyngeal squamous cell carcinoma (OPSCC) patients will respond to therapy is of utmost important for implementation treatment de-escalation reduce morbidity or testing novel therapeutic approaches. Due the lack reliable indicators response, we explored gene expression profile OPSCC in order better understand biology these tumors and identify biomarkers. In this study, investigated human genes associated with HPV transcription 80 samples from The Cancer...
Abstract Caspase-8 ( CASP8 ) is one of the most frequently mutated genes in head and neck squamous carcinomas (HNSCC), mutations are associated with poor overall survival. The distribution these HNSCC suggests that they likely to be inactivating. Inhibition has been reported sensitize cancer cells necroptosis, a unique cell death mechanism. Here, we evaluated how regulates necroptosis HSNCC using line models syngeneic mouse xenografts. In vitro , knockdown rendered HNSCCs susceptible induced...