A5043194384- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- Intensive Care Unit Cognitive Disorders
- Epigenetics and DNA Methylation
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
Imperial College London
2016-2021
Imperial College Healthcare NHS Trust
2016-2021
Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients sepsis.
Most epigenome-wide association studies (EWAS) quantify DNA methylation (DNAm) in peripheral tissues such as whole blood to identify positions the genome where variation is statistically associated with a trait or exposure. As comprises mix of cell types, it unclear whether trait-associated DNAm specific an individual cellular population. We collected three (whole blood, buccal epithelial and nasal cells) from thirty individuals. Whole samples were subsequently processed using...
Background In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects. Levosimendan (Simdax ® ; Orion Pharma, Newbury, UK) a calcium-sensitising drug with inotropic other properties that may role in sepsis. Objectives To determine, adult whether or not levosimendan reduces the incidence severity of acute organ dysfunction, effect on individual function safety profile levosimendan. Design...
Summary/Abstract Background Most epigenome-wide association studies (EWAS) quantify DNA methylation (DNAm) in peripheral tissues such as whole blood to identify positions the genome where variation is statistically associated with a trait or exposure. As comprises mix of cell types, it unclear whether trait-associated specific an individual cellular population. Methods We collected three (whole blood, buccal and nasal epithelial cells) from thirty individuals. Whole samples were subsequently...