A5056204601- Microbial Metabolic Engineering and Bioproduction
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Aerospace and Aviation Technology
- Electrochemical sensors and biosensors
- Evolution and Genetic Dynamics
- Adenosine and Purinergic Signaling
- Antioxidant Activity and Oxidative Stress
- Data Analysis with R
- Peroxisome Proliferator-Activated Receptors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Autonomous Vehicle Technology and Safety
- Metabolism and Genetic Disorders
- Genomics and Phylogenetic Studies
- Enzyme Catalysis and Immobilization
- Fungal and yeast genetics research
- Carbohydrate Chemistry and Synthesis
- Nutritional Studies and Diet
- Algal biology and biofuel production
- Spacecraft Dynamics and Control
- Microbial Natural Products and Biosynthesis
- GNSS positioning and interference
- Insurance, Mortality, Demography, Risk Management
- Inertial Sensor and Navigation
Imperial College London
2017-2024
Okinawa Institute of Science and Technology Graduate University
2023-2024
Imperial Consultants
2023
Abstract Nutritional codependence (syntrophy) has underexplored potential to improve biotechnological processes by using cooperating cell types. So far, design of yeast syntrophic communities required extensive genetic manipulation, as the co-inoculation most eukaryotic microbial auxotrophs does not result in cooperative growth. Here we employ high-throughput phenotypic screening systematically test pairwise combinations auxotrophic Saccharomyces cerevisiae deletion mutants. Although...
Microorganisms can be engineered to sustainably produce a variety of products including fuels, pharmaceuticals, materials, and food. However, highly strains often result in low production yield, due undesired effects such as metabolic burden the toxicity intermediates. Drawing inspiration from natural ecosystems, construction synthetic community with division labor offer advantages for bioproduction. This approach involves dividing specific tasks among members, thereby enhancing...
Abstract The non-natural needs of industrial applications often require new or improved enzymes. structures and properties enzymes are difficult to predict design de novo . Instead, semi-rational approaches mimicking evolution entail diversification parent followed by evaluation isolated variants. Artificial selection pressures coupling desired enzyme cell growth could overcome this key bottleneck, but usually narrow in scope. Here we show diverse using the ubiquitous cofactors nicotinamide...
Abstract Motivation Group I introns are one of the most widely studied ribozymes. Since their initial discovery, a large number them have been identified experimentally or computationally. However, no comprehensive and unified database that provides group intron sequences with precise boundaries structural information is available. Results We created new reliable exon-intron boundaries. The offers additional data for each sequence, such as containing GenBank entry, its position within...
The increase in air traffic the recent years has motivated development of technologies to monitor space and warn about possible collisions by predicting trajectories that will be followed aircraft. In this field, neural networks have become prominent thanks their potential learn predict maneuvers without providing aspects are difficult model such as atmospheric conditions, or detailed aircraft parameters. A variety models been proposed; however, these often tested very limited setups,...
Over the past few years, amount of artificial satellites orbiting Earth has grown fast, with close to a thousand new launches per year. Reliable calculation evolution satellites' position over time is required in order efficiently plan launch and operation such satellites, as well avoid collisions that could lead considerable losses generation harmful space debris. Here, we present asteRisk, first R package for analysis trajectory satellites. The provides native implementations different...
rfaRm is an R package providing a client-side interface for the Rfam database of non-coding RNA and other structured elements. The facilitates search by keywords or sequences, as well retrieval all available information about specific families, such member multiple sequence alignments, secondary structures covariance models. By programmatic access to database, enables genomic workflows incorporate RNA, whose potential cannot be fully exploited just through interactive database. features are...
Aviation data has become increasingly more accessible to the public thanks adoption of technologies such as Automatic Dependent Surveillance-Broadcast (ADS-B) and Mode S, which provide aircraft information over publicly radio channels.Furthermore, OpenSky Network provides multiple resources access air traffic from a large network ADS-B receivers.Here, we present openSkies, first R package for processing data.The an interface resources, standardized structures represent different entities...
The complete genome sequence of Paraclostridium bifermentans was obtained by assembly Illumina and Oxford Nanopore (ONT) reads. will enable study into the organism's ability to biohydrogenate unsaturated acyl chains in transformation C20 polyunsaturated fatty acids (PUFAs) corresponding bioactive non-methylene-interrupted (NMIFAs).