A5072544547- Glioma Diagnosis and Treatment
- Motor Control and Adaptation
- Brain Metastases and Treatment
- Ocular Oncology and Treatments
- Sport Psychology and Performance
- Connective Tissue Growth Factor Research
- Hedgehog Signaling Pathway Studies
- Anatomy and Medical Technology
- Cerebral Palsy and Movement Disorders
- Action Observation and Synchronization
- Evolution and Paleontology Studies
- Genetic and Kidney Cyst Diseases
- Innovations in Medical Education
- Congenital heart defects research
- Biomedical and Engineering Education
- Robotic Locomotion and Control
- Paleontology and Evolutionary Biology
- Epigenetics and DNA Methylation
- Amphibian and Reptile Biology
New York Institute of Technology
2022-2025
National Institute of Neurological Disorders and Stroke
2025
National Institutes of Health
2025
Abstract Background Choroid plexus (CP) tumors are rare brain neoplasms that mainly affect the pediatric population. Unlike benign CP papilloma (CPP), carcinoma (CPC) is an aggressive cancer with a dismal survival rate. Despite chromosome-wide rearrangements, drivers of most remain elusive except recurrent alterations in TP53. Studies signaling dysregulation may bring biological understanding these malignancies. Previous studies implicated NOTCH tumors; we developed mouse models driven by...
Climbing represents a critical behavior in the context of primate evolution. However, anatomically modern human populations are considered ill-suited for climbing. This adaptation can be attributed to evolution striding bipedalism, redirecting anatomical traits away from efficient Although prior studies have speculated on kinetic consequences this reorganization, there is lack data force profiles climbers. study utilized high-speed videography and plate analysis assess single limb forces...
Abstract Access to high‐quality outreach programs is crucial for preparing students STEM careers, yet traditional classrooms often lack diverse, hands‐on learning opportunities, particularly in anatomy and evolutionary biology. We present "Are You Stronger Than a Lemur?"—an interactive activity that introduces K‐12 fundamental concepts anatomy, evolution, physics, data analysis through real‐world applications. Participants formulate hypotheses, collect analyze data, engage with age‐tailored...
Abstract Multiciliated cells (MCCs) in the brain reside ependyma and choroid plexus (CP) epithelia. The CP secretes cerebrospinal fluid that circulates within ventricular system, driven by ependymal cilia movement. Tumors of are rare primary neoplasms mostly found children. tumors exist three forms: papilloma (CPP), atypical CPP, carcinoma (CPC). Though CPP generally benign can be resolved surgery, CPC is a particularly aggressive little understood cancer with poor survival rate tendency for...
Brachiation is a form of suspensory locomotion observed only in Primates. The non-human hominoids (e.g., gibbons, orangutans, chimpanzees, and gorillas) are considered specialized brachiators, yet peculiar among the living apes anatomically modern humans (Homo sapiens), who have forgone this locomotor mode favor bipedal striding. Humans can, however, brachiate seem to retained capabilities their arboreal ancestors. However, mechanics human brachiation not been quantified. In study, we...
Synopsis Center of mass (COM) mechanics, often used as an energetic proxy during locomotion, has primarily focused on level movement and hardly explores climbing scenarios. This study examines three-dimensional COM movements across five phylogenetically distinct species to test theoretical expectations costs, explore how interspecific variation (i.e., different limb numbers, adhesion mechanisms, body masses [0.008–84 kg], postures) affects determine the impact out-of-plane costs. A parallel...
Abstract Choroid plexus (CP) tumors encompass a spectrum of rare brain neoplasms ranging from benign papilloma (CPP) to aggressive carcinoma (CPC) that collectively affect the pediatric population. Poor outcomes for high-grade lesions and side effects current treatment paradigms underscore critical need develop safer more efficacious therapies guided by biological understanding these tumors. We developed mouse models common molecular defects found in human disease. These exploit sustained...
Abstract BACKGROUND Choroid plexus (CP), an epithelial structure within the brain ventricles, produces cerebrospinal fluid and serves barrier functions in brain. Primary CP neoplasms are rare intracranial tumors that predominantly occurs childhood. Recent studies revealed multiciliated cells humans mice. In contrast, benign papilloma, malignant carcinoma (CPC) characterized by solitary cilia, disturbances to multiciliation program directed transcription factor GMNC. Additionally, most CPC...
Abstract Choroid plexus (CP) neoplasms are rare, predominantly pediatric, brain tumors ranging from benign CP papilloma to aggressive carcinoma (CPC) associated with poor survival. Survivors often experience devastating side effects current treatment strategies. There is an urgent need for safer, more effective therapies CPC. A subset of human CPC exhibits abnormal NOTCH activity, whereas mutations tumor suppressor gene TP53 detected in >50% and increased genetic instability worse...
Abstract Choroid plexus (CP) tumors are rare primary brain neoplasms found most commonly in children and thought to arise from CP epithelial cells. Sox2 is a transcription factor that not only plays role development the ventricular zone, CP, roof plate, but also contributes cancer stemness, tumorigenesis, drug resistance. Gene expression studies demonstrate aberrant human tumors, suggesting tumor development. A subset of exhibit abnormal NOTCH pathway activity. Using animal models, we...