Erythropoietin (Epo) prevents ischemia and hypoxia-induced neuronal death in vitro. Recent studies have shown that this cytokine also has vivo neuroprotective effects cerebral spinal adult rodents. In study, we aimed to investigate the effect of systemically administered recombinant human Epo on infarct volume apoptotic a newborn rat hypoxic-ischemic brain injury model. Our results showed single dose intraperitoneal treatment (1,000 U/kg) significantly decreased mean as compared control...

We have previously shown that erythropoietin (Epo) exerts neuroprotective effects in the Rice-Vannucci model of neonatal hypoxic-ischemic brain injury. However, mechanisms Epo protection this are still unclear.In present study, we studied systemically administered on lipid peroxidation levels and antioxidant enzyme (superoxide dismutase glutathione peroxidase) activities following injury rats.Seven-day-old Wistar rat pups were subjected to left carotid artery occlusion followed by 2.5 h...

This study aimed to compare the recently published prescriptive INTERGROWTH-21st standards with commonly used intrauterine based Fenton growth in terms of birth size classification and extrauterine restriction (EUGR) incidence a sample very preterm infants.The anthropometric measures infants born before 32 weeks gestation at Dokuz Eylul University Hospital during period from January 2012 February 2016 were obtained birth, 36th gestational or time discharge. Birth data presented as...

Respiratory distress syndrome is the leading cause of respiratory failure in preterm infants. The incidence and severity are inversely related to gestational age newborn. major underlying pathophysiologic mechanisms surfactant deficiency anatomic, structural immaturity lung. Recent improvements such as antenatal steroid treatment enhance pulmonary maturity, appropriate resuscitation facilitated by placental transfusion immediate use continuous positive airway pressure for alveolar...

Progressive compromise of antioxidant defenses and free radical-mediated lipid peroxidation, which is one the major mechanisms secondary traumatic brain injury (TBI), has also been reported in pediatric head trauma. In present study, we aimed to demonstrate effect melatonin, a potent radical scavenger, on oxidative damage 7-day-old rat pups subjected contusion injury. Whereas TBI significantly increased thiobarbituric acid reactive substances (TBARS) levels, there was no compensatory...

Periventricular leukomalacia (PVL), a common neonatal brain white matter (WM) lesion, is frequently associated with cerebral palsy. Growing evidence has indicated that in addition to ischemia/reperfusion injury, cytokine-induced injury maternal or fetal infection may also play an important role the pathogenesis of PVL. Recent studies have shown administration lipopolysaccharide (LPS) pregnant rats causes enhanced expression cytokines, i.e., IL-1β, TNF-α, and IL-6, brains. In recent years, it...

High-frequency oscillatory ventilation (HFOV) with volume guarantee (VG) is a new mode that allows the clinician to set mean tidal be delivered.This study aimed investigate whether HFOV VG option may result in constant delivery and less fluctuant CO2 levels compared alone premature infants respiratory distress syndrome (RDS).Inborn at than 32 weeks of gestation RDS requiring invasive mechanical were eligible. Patients randomized receive + or as initial ventilator then crossed over other...

Erythropoietin (Epo) exerts neuroprotection against neuronal death induced by ischemia and hypoxia in vitro vivo. Recent studies suggest that the neuroprotective effects of Epo may depend upon different mechanisms, including inhibition nitric oxide (NO). We recently demonstrated a model neonatal hypoxic-ischemic brain damage. In present study, we directly determined whether systemic administration recombinant modulates cerebral NO production rat injury. Seven-day-old Wistar pups were...

Abstract Background: Because there is a lack of well‐established criteria, the aim present paper was to determine risk factors predict duration tachypnea in transient newborn (TTN). Methods: Data from 95 newborns with TTN were evaluated retrospectively. Clinical and laboratory findings compared between patients whom lasted <72 h (group 1) or >72 2). Results: Male gender, prematurity delivery by cesarean section major for TTN. Parenteral furosemide had no effect on clinical course. Peak...

Caffeine treatment reduces the frequency of apnoea prematurity (AOP) and eliminates need for mechanical ventilation by acting as a nonspecific inhibitor adenosine A1 2A receptors. Patients with AOP have demonstrated variant responses to caffeine therapy. We proposed investigate role polymorphisms in development individual differences response. Secondly, we aimed determine whether these any effect on bronchopulmonary dysplasia (BPD) development.Cord blood samples were collected from infants...

The epigenetic effects of transmission certain regulatory molecules, such as miRNAs, through maternal milk on future generations, are still unknown and have not been fully understood yet. We hypothesized that breastfeeding regularly by adoptive-mother may cause miRNAs regulating factors to the infant, marriage milk-siblings various pathologies in generations.A cross-fostering model using a/a A vy /a mice had established. F2 milk-sibling control groups were obtained from mating or unrelated...

In this study, we investigated the relationship between infantile colic, migraine, and biorhythm regulation, by evaluating biochemical molecular parameters.Healthy infants with without colic were eligible for prospective cohort study. A questionnaire was applied. Between 6th 8th postnatal weeks, day night circadian histone gene H3f3b mRNA expression spot urine excretion of serotonin, cortisol, 6-sulphatoxymelatonin analyzed.Among 95 included, 49 diagnosed colic. group, defecation difficulty,...

It has been shown that leptin is present in breast milk and human mammary epithelial cells are able to synthesize leptin. suggested might be involved the regulation of postnatal nutrition growth.To investigate whether there a relationship between levels weight gain period compare variations milk-borne maternal concentrations for small gestational age (SGA), large (LGA) appropriate (AGA) infants.Forty-seven healthy lactating women aged from 17-38 years their infants were included study. The...

Perinatal asphyxia is an important cause of neonatal mortality and subsequent serious sequelae such as motor cognitive deficits seizures. The ameliorative effect erythropoietin (Epo) on experimental hypoxic-ischemic brain injury in rats has been recently reported. Recent studies also confirm the antiapoptotic Epo a variety vitro vivo neuronal models including injury. However, molecular mechanisms protection this model are unclear. may exert its via differential regulation expression genes...

Objectives: Periventricular leukomalacia (PVL) is the predominant form of brain injury in premature infants, and no specific treatment currently exists for this condition. We have evaluated whether maternal omega-3 fatty acid (ω3 FA) reduces endotoxin-induced PVL developing rat brain. Methods: Wistar rats with dated pregnancies were fed a standard diet or enriched ω3 FA (70% docosahexaenoic + 30% eicosapentaenoic mixture) during gestation. Intraperitoneal injection lipopolysaccharide (LPS)...

ABSTRACT Objective: Breast milk is an important source of bacteria in establishing the infantile intestinal microbiota that appear to influence enterohepatic circulation bilirubin. The aim present study was evaluate effect breast milk's microbiological content on development jaundice (BMJ). Methods: A total number 60 mother‐infant pairs enrolled study. Two groups were defined: BMJ group (n = 30), full‐term otherwise healthy newborns who considered BMJ; control without jaundice. All...

Aim : To discuss intestinal side effects of ibuprofen in the treatment patent ductus arteriosus, after having observed two cases spontaneous perforation following treatment. Methods Clinical and laboratory records preterm infants, who developed administration, were evaluated. Results Gestational ages infants 29 wk (male) 30 (female). Both perforations without signs necrotizing enterocolitis. The cured with Penrose drainage alone. Conclusion Although is a reasonable alternative to...