A5101881986- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Bioinformatics and Genomic Networks
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Lung Cancer Research Studies
- Leaf Properties and Growth Measurement
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Esophageal Cancer Research and Treatment
- Horticultural and Viticultural Research
- Genetics and Plant Breeding
- HER2/EGFR in Cancer Research
- Appendicitis Diagnosis and Management
- Spectroscopy and Chemometric Analyses
- Advanced Proteomics Techniques and Applications
- Legume Nitrogen Fixing Symbiosis
- Advanced Chemical Sensor Technologies
- Soybean genetics and cultivation
- Genetic Mapping and Diversity in Plants and Animals
Defence Science and Technology Group
2021
Cell Signaling Technology (United States)
2013-2018
Purdue University West Lafayette
2017
UW Health University Hospital
2013-2015
University of Wisconsin–Madison
2011-2013
University College Dublin
2011
Digital imagery can help to quantify seasonal changes in desirable crop phenotypes that be treated as quantitative traits. Because limitations precise and functional phenotyping restrain genetic improvement the postgenomic era, imagery-based phenomics could become next breakthrough accelerate gains field crops. Whereas many phenomic studies focus on exploratory analysis of spectral data without obvious interpretative value, we used images directly measure soybean canopy development from...
Integrated multiomics network analysis reveals signaling profiles in lung cancer.
Background . Improved detection of adenomatous polyps using i-SCAN has mixed results in small studies. Utility as a primary surveillance modality for colorectal cancer screening during colonoscopy is uncertain. Aim Comparing high definition white light endoscopy (HDWLE) to their ability detect adenomas colonoscopy. Methods Prospective cohort study 1936 average risk patients who had at an ambulatory procedure center. Patients underwent with withdrawal versus endoscopic exam. Primary outcome...
Supervised machine learning techniques have become well established in the study of spectroscopy data. However, unsupervised technique cluster analysis hasn’t reached same level maturity chemometric analysis. This paper surveys recent studies which apply to NIR and IR In addition, we summarize current practices contrast these with literature from pattern recognition domain. includes data pre-processing, feature extraction, clustering distance metrics, algorithms validation techniques....
Abstract Recent genomic-based studies have suggested ovarian cancer is a disease of copy instability, with 63 regions focal amplification, rather than driven by mutation. However, this analysis has been unable to identify changes in protein expression, modification, and activity. In study we developed highly quantitative MS/MS approach examine the ratio levels, combining TMT labeling number motif site-specific antibodies deregulated signaling pathways between tumor normal specimens. We...
Colorectal cancer screening with colonoscopy is founded on the early detection and treatment of pre-malignant malignant lesions. A post processing software filter (Pentax, I-Scan TM), was designed to improve real-time in-vivo rates mucosal I-scan technology employs specialized algorithms that surface contrast enhancement white light making lesions more distinct. To compare high definition combined standard in ability detect polyps, adenomas advanced total 1,964 patients underwent average...
Abstract Non-small cell lung cancer (NSCLC) is the most common form of cancer, afflicting nearly 200,000 people in United States each year. Abnormal ALK found about 5% NSCLC cases, meaning more than 5,000 new patients could benefit from tyrosine kinase inhibitor (TKI) crizotinib. However, not all such treatment, with clinical response to crizotinib differing among who harbor same molecular abnormality. Similarly, fusion proteins have shown varying sensitivity HSP90 geldanamycin preclinical...
Abstract In virtually all epithelial tumors, growth factor receptor activity is deregulated by activated mutations, genomic amplification, and autocrine loops. The dependence of tumor cell survival upon the driving oncogene has been called “oncogene addiction” demonstrates acute sensitivity cancer cells to inhibition pathways their proliferation, survival. Major questions regarding solid tumors targeted kinase inhibitors why some respond others do not ones which still are able develop...