A5041007490- Cancer Immunotherapy and Biomarkers
- Cholinesterase and Neurodegenerative Diseases
- Retinoids in leukemia and cellular processes
- HIV Research and Treatment
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Immunotherapy and Immune Responses
- Colorectal and Anal Carcinomas
- Insect and Pesticide Research
- Enzyme function and inhibition
- Insect Pest Control Strategies
- Cancer, Stress, Anesthesia, and Immune Response
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and Biological Activities
- Diverse Scientific Research Studies
- Aldose Reductase and Taurine
- Nigella sativa pharmacological applications
- Herbal Medicine Research Studies
- Pesticide Exposure and Toxicity
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Amyotrophic Lateral Sclerosis Research
- Systemic Lupus Erythematosus Research
- HIV-related health complications and treatments
Mansoura University
2021-2025
Damietta University
2022
Cairo University
2022
Ministry of Health of the Russian Federation
2022
Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have shown synergistic effects on tumor progression. Seeking to develop dual BRAF/VEGFR-2 inhibitors, we synthesized 18 amino-benzothiazole derivatives with structural similarities reported inhibitors. Four compounds-
Abstract Hesperidin, a natural flavanone glycoside predominantly found in citrus fruits, has gained attention for its wide-ranging biological activities, including potential insecticidal properties. Culex pipiens , commonly known as the northern house mosquito, is major vector of several human pathogens, such West Nile virus and filariasis, making it key target fight against vector-borne diseases. In this study, we evaluated larvicidal activity Hesperidin larvae, assessing an alternative to...
This research study describes the development of new small molecules based on 2,4-thiazolidinedione (2,4-TZD) and their aldose reductase (AR) inhibitory activities. The synthesis 17 derivatives 2,4-TZDs hybrids was feasible by incorporating two known bioactive scaffolds, benzothiazole heterocycle, nitro phenacyl moiety. most active hybrid (8b) found to inhibit AR in a non-competitive manner (0.16 µM), as confirmed kinetic studies molecular docking simulations. Furthermore, vivo experiments...
Despite the intense research work since beginning of pandemic, pathogenesis COVID-19 is not yet clearly understood. The previous mechanism COVID-19, based on ACE2 tropism and explained through a single receptor, insufficient to explain due absence angiotensin-converting enzyme 2 (ACE2) receptors in most affected organs. In current study, we used PatchDock server run molecular docking study both gonadotropin-releasing hormone receptor (GnRHR) G-protein-coupled-receptor (GPCR) with SARS-CoV-2...
A comparative study was conducted on the essential oils (EOs) chemical composition from two subspecies of wild Mentha longifolia typhoides and schimperi, growing in Egypt, followed by biological investigation EOs as antibacterial, antiquorum sensing burn wound healing agents. Gas chromatography/mass spectrometry analysis hydro-distillated led to identification 99 % oil components. Schimperi revealed broadspectrum antibacterial activity with MIC values 156 ∼ 625 μg/ml, lower than or close...
Background: Breast cancer is the most prevalent malignant tumour in women of all races and second largest cause cancer-related death majority races. Based on pattern gene expression, five intrinsic or molecular classifications for breast tumours are frequently used. Our research, which presently being utilized to treat has potential significantly change course illness, focused two them: luminal B triplenegative/ basal-like cancer. Methods: Screening a database containing millions drug...
In recent years, novel strategies to control insects have been based on protease inhibitors (PIs). this regard, molecular docking and dynamics simulations extensively used investigate insect gut proteases the interactions of PIs for development resistance against insects. We, herein, report an in silico study (disodium 5'-inosinate petunidin 3-glucoside), (calcium 5'-guanylate chlorogenic acid), acid alone, (kaempferol-3,7-di-O-glucoside with hyperoside delphinidin (myricetin 3'-glucoside...
Abstract: A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at end 2019. Although, ACE2 receptor has been demonstrated to be main entry COVID-19, but our docking analysis, predicted and discovered a novel termed STRA 6 that may play critical role pathogenicity COVID-19. STRA6 expressed many organs immune cells, upregulated retinoic acid jm6 (STRA 6) was first protein identified category proteins, cytokine...
Background:: In the case of COVID-19 patients, it has been observed that immune system infected person exhibits an extreme inflammatory response known as cytokine release syndrome (CRS) where cytokines are swiftly produced in quite large amounts to infective stimuli. Numerous studies patients with severe symptoms have documented presence higher plasma concentrations human interleukin-6 (IL-6), which suggests IL-6 is a crucial factor pathophysiology disease. order prevent CRS drugs can...
Using the gas chromatography mass spectrometry method, chemical components of essential oil from flowers Lantana camara growing in Egypt are analyzed.
As a DNA mismatch repair deficit (dMMR) anticancer medication, and humanized monoclonal antibody (hmAb), Tislelizumab has attracted significant interest in recent years. The programmed cell death protein-1 (PD-1) its ligands (PD-L1/CD274/B7-H1 PDL2/CD273) may bind to each other with great affinity. This binding prevents activated T-cells from continuing proliferate, produce cytokines, engage cytotoxic action. B7:PD-1 inhibitory immunological checkpoint receptor binds the B7-2(CD86)...
The progressive loss of CD4+ T cell population and thymic dysfunction is the hallmark HIV-1 (human immunodeficiency virus-1) infection but mechanism underlying slow decline involution remains elusive. Although chemokine receptor CCR5 (cysteine-cysteine 5) predominant co-receptor exploited for transmission replication HIV in vivo previous described via CCR5, based on single-receptor tropism, was insufficient to elucidate cells caused by infection. It has been demonstrated that acute causes...
Abstract The progressive loss of CD4+ T cell population and thymic dysfunction is the hallmark HIV-1 (human immunodeficiency virus-1) infection but mechanism underlying slow decline involution remains elusive. Although chemokine receptor CCR5 (cysteine-cysteine 5) predominant co-receptor exploited for transmission replication HIV in vivo previous described via CCR5, based on single-receptor tropism, was insufficient to elucidate cells caused by infection. It has been demonstrated that acute...
This article has been withdrawn from the journal Letters in Drug Design & Discovery due to a conflict of interest among authors. Bentham Science apologizes readers for any inconvenience this may have caused. The Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/pages/editorial-policies-main BENTHAM SCIENCE DISCLAIMER: It is prerequisite publication that manuscripts submitted not published and will simultaneously or elsewhere. Furthermore, data,...
Abstract Dostarlimab is antitumor drug that mainly prescribed for treating endometrial cancer (cancer of the lining uterus or womb) mismatch repair deficient (dMMR) in patients whose has returned, it spread cannot be removed by surgery. a type humanized monoclonal antibody binds with high affinity to PD-1, resulting inhibition binding PD-L2 and PD-L1. Surprisingly, was showed dozen colorectal (A total 12 patients) have experienced complete response this treatment after months completion...
Abstract Dostarlimab is antitumor drug that mainly prescribed for treating endometrial cancer (cancer of the lining uterus or womb) mismatch repair deficient (dMMR) in patients whose has returned, it spread cannot be removed by surgery. a type humanized monoclonal antibody binds with high affinity to PD-1, resulting inhibition binding PD-L2 and PD-L1. Surprisingly, was showed dozen colorectal (A total 12 patients) have experienced complete response this treatment after months completion...
Abstract Great strides have been made to reduce the number of human immunodeficiency virus (HIV) infections and HIV/acquired syndrome (AIDS)-related deaths, but war against HIV is far from over. From 1981 present, virus, etiological agent AIDS, has unwaveringly killed an estimated 39 million individuals. Although, chemokine receptor CCR5 predominant co-receptor exploited for transmission replication in vivo our docking analysis, predicted discovered a novel termed STRA 6 that may play...