A5027662862- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Telomeres, Telomerase, and Senescence
- Tissue Engineering and Regenerative Medicine
- melanin and skin pigmentation
- Plant Surface Properties and Treatments
- Skin Protection and Aging
- 3D Printing in Biomedical Research
National University of Singapore
2020-2023
Significance The mechanical reprogramming of fibroblasts, followed by their redifferentiation into rejuvenated fibroblasts in an optimized 3D collagen matrix, made these cells more contractile and efficient at synthesizing matrix components including laminin, fibronectin, collagen-IV. Moreover, the obtained through this approach exhibited a decrease DNA damage. derived from method precisely align tissue architectures, suggesting its potential application as clinical implants engineering...
YAP and its paralog TAZ are the nuclear effectors of Hippo tumour-suppressor pathway, function as transcriptional co-activators to control gene expression in response mechanical cues. To identify both common unique targets gastric cancer cells, we carried out RNA-sequencing analysis overexpressed or corresponding paralogous gene-knockouts (KOs), KO KO, respectively. Gene Ontology (GO) YAP/TAZ-transcriptional revealed activation genes involved platelet biology lipoprotein particle formation...