A5004776832- Aquatic Ecosystems and Biodiversity
- Fish Biology and Ecology Studies
- French Urban and Social Studies
- Cellular transport and secretion
- Fish Ecology and Management Studies
- Fish biology, ecology, and behavior
- Aquatic Ecosystems and Phytoplankton Dynamics
- Aquatic Invertebrate Ecology and Behavior
- Agriculture and Rural Development Research
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Parasitic Diseases Research and Treatment
- Lipid Membrane Structure and Behavior
- African Botany and Ecology Studies
- Neurological disorders and treatments
- Parasite Biology and Host Interactions
- Rangeland Management and Livestock Ecology
- Myasthenia Gravis and Thymoma
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Mediterranean and Iberian flora and fauna
- Marine and fisheries research
- Ecology and biodiversity studies
- Freshwater macroinvertebrate diversity and ecology
- Conservation, Biodiversity, and Resource Management
Inserm
2014-2024
Aix-Marseille Université
2012-2024
Unité de Neurobiologie des canaux Ioniques et de la Synapse
2004-2024
Institut de Recherche pour le Développement
2007-2022
Académie de Paris
2007-2022
Sorbonne Université
2002-2016
Centre National de la Recherche Scientifique
1990-2016
Biologie des Organismes et Écosystèmes Aquatiques
1997-2016
Maison des Sciences de l'Homme
1994-2016
Yves Rocher (France)
2016
Fresh water figures prominently in the machinery of Earth system and is key to understanding full scope global change. Greenhouse warming with a potentially accelerated hydrologic cycle already well‐articulated science issue, strong policy implications. A broad array other anthropogenic factors—widespread land cover change, engineering river channels, irrigation consumptive losses, aquatic habitat disappearance, pollution—also influences direct important ways. rich history site‐specific...
Immunoglobulin G fractions from patients with Lambert-Eaton myasthenic syndrome (LEMS), an autoimmune disease of neuromuscular transmission, immunoprecipitate 125I-labeled omega-conotoxin GVIA-labeled calcium channels solubilized rat brain. A 58-kDa antigen was detected by probing Western blots partially purified LEMS plasma and IgG shown to be the relevant in receptor immunoprecipitation. Monoclonal antibody 1D12, produced immunizing mice synaptic membranes, has properties similar these...
omega-Conotoxin-sensitive N-type calcium channels control neurotransmitter release at the nerve terminal and interact with proteins implicated in secretion. Solubilized omega-conotoxin receptors from rat brain synaptic membrane were immunoprecipitated by antibodies against channel alpha 1 subunits, syntaxin, a 105-kDa plasma protein. A multimeric complex, composed of that showed varying degrees association, was purified procedure involving anti-syntaxin immunoaffinity chromatography. 250-kDa...
P- and Q-type calcium channels, which trigger rapid neurotransmitter release at many mammalian synapses, are blocked by ω-conotoxin MVIIC. <sup>125</sup>I-ω-Conotoxin MVIIC binding to rat cerebellar synaptosomes was not displaced ω-conotoxins GVIA or MVIIA (<i>K</i><sub>i</sub> > 1 μM), selective for N-type channels. Solubilized <sup>125</sup>I-ω-conotoxin receptors were specifically recognized antibodies directed against α<sub>1</sub>A channel subunits, proteins known constitute a pore with...
Mutations in SRPX2 (Sushi-Repeat Protein, X-linked 2) cause rolandic epilepsy with speech impairment (RESDX syndrome) or altered development of the cortex (bilateral perisylvian polymicrogyria). The physiological roles remain unknown to date. One way infer function relies on identification as yet protein partners. Using a combination interactome approaches including yeast two-hybrid screening, co-immunoprecipitation experiments, cell surface binding and plasmon resonance (SPR), we show that...
Residual activation of the cortex was investigated in nine patients with complete spinal cord injury between T6 and L1 by functional magnetic resonance imaging (fMRI). Brain activations were recorded under four conditions: (1) a patient attempting to move his toes flexion-extension, (2) imagining same movement, (3) passive proprio-somesthesic stimulation big without visual control, (4) control patient. Passive generated posterior central sulcus three who also showed somesthesic evoked...
Synaptic core complex formation is an essential step in exocytosis, and assembly into a superhelical structure may drive synaptic vesicle fusion. To ascertain how Ca(2+) could regulate this process, we examined calmodulin binding to recombinant components. Surface plasmon resonance pull-down assays revealed Ca(2+)-dependent (K(d) = 500 nM) glutathione S-transferase fusion proteins containing synaptobrevin (VAMP 2) domains but not syntaxin 1 or synaptosomal-associated protein of 25 kDa...
Significance Botulism is induced by Clostridium botulinum neurotoxins (BoNTs). At neuromuscular junctions, BoNT/B binds to dual receptors: a plasma membrane resident polysialoganglioside and synaptotagmin, synaptic vesicle protein transiently inserted in neuronal membranes upon exocytosis. It widely thought that BoNT initially gangliosides this binary complex then diffuses interact with synaptotagmin. Here, we show the true receptor preassembled GT1b–SYT α-helical structure of binding domain...
Cysteine string proteins (Csps) are J-domain chaperone anchored at the surface of synaptic vesicles. Csps involved in neurotransmitter release and may modulate presynaptic calcium channel activity, although molecular mechanisms unknown. Interactions between Csps, core (SNARE) complex, P/Q-type channels were therefore explored. Co-immunoprecipitation suggested that occur complexes containing synaptobrevin (VAMP), but not syntaxin 1, SNAP-25, nor labeled with125I-ω-conotoxin MVIIC. However...
Historical background.- I. The lacustrine environment and its evolution.- 1. Paleolimnology of an upper quaternary endorheic lake in Chad Basin.- 2. environment.- 3. Physical chemical characteristics the waters.- 4. Hydrochemical regulation lake.- II. main types communities their evolution during a drought period.- 5. aquatic vegetation Lake Chad.- 6. phytoplankton.- 7. zooplankton.- 8. benthic fauna: ecology, biomass communities.- 9. fauna associated with vegetation.- 10. Fish rivers...