A5103081220- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Genomics and Phylogenetic Studies
- Reproductive Health and Contraception
- Hormonal and reproductive studies
- CAR-T cell therapy research
- HIV Research and Treatment
- Virology and Viral Diseases
- HIV-related health complications and treatments
- Multiple Myeloma Research and Treatments
- Immune Response and Inflammation
- Probiotics and Fermented Foods
- Prenatal Screening and Diagnostics
Bristol-Myers Squibb (United States)
2023
Gladstone Institutes
2018-2022
Mackay Memorial Hospital
2012-2019
Mackay Junior College of Medicine, Nursing and Management
2019
Mackay Medical College
2019
Taipei City Hospital
2012-2019
Taipei Medical University
2019
Laboratory mice are widely studied as models of mammalian biology, including the microbiota. However, much taxonomic and functional diversity mouse gut microbiome is missed in current metagenomic studies, because genome databases have not achieved a balanced representation diverse members this ecosystem. Towards solving problem, we used flow cytometry low-coverage sequencing to capture genomes 764 single cells from stool three laboratory mice. From these, generated 298 high-coverage...
Abstract Innate immune responses to Zika virus (ZIKV) are dampened in the lower female reproductive tract (LFRT) compared other tissues, but mechanism that underlies this vulnerability is poorly understood. Using tissues from uninfected and vaginally ZIKV-infected macaques mice, we show low basal expression of RNA-sensing pattern recognition receptors (PRRs), or their co-receptors, LFRT contributes high viral replication tissue. In LFRT, ZIKV sensing provides limited protection against...
To report successful pregnancy outcomes in three cases of documented premature ovulation intracytoplasmic sperm injection (ICSI) cycles.Three were noted during the oocyte retrieval procedures vitro fertilization (IVF)/ICSI cycles with gonadotropin-releasing hormone antagonist protocol. Immature oocytes aspirated from remaining small and medium-sized follicles maturation performed two cases. All achieved live birth after ICSI.This is first ever outcome ovulation. Fertilizable pregnancies can...
Latent HIV infection is the main barrier to cure, and most HIV-infected cells reside in gut, where distinct but unknown mechanisms may promote viral latency. Transforming growth factor β (TGF-β), which induces expression of CD103 on tissue-resident memory T cells, has been implicated Using as a surrogate marker identify that have undergone TGF-β signaling, we compared RNA/DNA contents cellular transcriptomes
(Abstracted from Reprod Biol Endocrinol 2019;17:7) As the prevalence of fertility treatment increases, research into managing “diminished ovarian reserve” (DOR) remains a challenge. A “dual trigger” consisting gonadotropin hormone–releasing hormone agonist (GnRH-a) in combination with reduced dose human chorionic (hCG) showed robust evidence increased pregnancy and live birth rate without hyperstimulation vitro fertilization (IVF) cycles for high responders.
Background: Survival outcomes are poor in patients with relapsed and refractory multiple myeloma (RRMM) who triple-class–exposed (TCE) to immunomodulatory (IMiD®) agents, proteasome inhibitors (PIs), anti-CD38 monoclonal antibodies. As become TCE earlier lines of therapy, treatment options limited. Idecabtagene vicleucel (ide-cel) demonstrated deep durable responses heavily pretreated RRMM. Methods: KarMMa-3 (NCT03651128), an international, open-label, randomized controlled trial, enrolled...
Abstract Laboratory mice are widely studied as models of mammalian biology, including the microbiota. However, much taxonomic and functional diversity mouse gut microbiome is missed in current metagenomic studies, because genome databases have not achieved a balanced representation diverse members this ecosystem. Towards solving problem, we used flow cytometry low-coverage sequencing to capture genomes 764 single cells from stool three laboratory mice. From these, generated 298 high-coverage...