Background The mechanisms underlying the possible contribution of chronic inflammation to development hypertension remain unclear. We examined longitudinal association with progression vascular and/or renal abnormalities in hypertension. Methods and Results In 3274 middle‐aged Japanese men without at study baseline, brachial‐ankle pulse wave velocity, blood pressure, estimated glomerular filtration rate, serum CRP (C reactive protein) levels were measured annually during a 9‐year period....

This study analyzed repeated measurement data to clarify the longitudinal associations between hyperuricemia and risk factors for development of hypertension (ie, increased arterial stiffness, renal dysfunction, inflammation), then examined whether these show with hypertension. In 3274 Japanese men without hypertension, brachial-ankle pulse wave velocity, blood pressure, estimated glomerular filtration rate, serum uric acid CRP (C-reactive protein) levels were measured annually over an...

We examined which pathophysiological abnormalities of vascular function might be closely associated with abnormal baroreflex regulation in subjects hypertension.In the cross-sectional assessment, 280 hypertension were enrolled for measurement brachial-ankle pulse wave velocity (baPWV), radial augmentation index (rAI), flow-mediated vasodilatation (FMD) brachial artery and baroreceptor sensitivity (BRS). These parameters measured again as prospective assessment some these subjects. In after...

We conducted analyses of repeated-measures data to examine whether pressure wave reflection acts additively or synergistically with arterial stiffness in the pathogenesis hypertension.In 3172 middle-aged (42±9 years) healthy Japanese men without hypertension at study baseline, systolic and diastolic blood pressures, brachial-ankle pulse velocity, radial augmentation index were measured annually during a 9-year period. Of these, 474 participants (15%) developed by end Binary logistic...

We examined the following: whether estimated glomerular filtration rate calculated from serum cystatin C levels (eGFRcys) and brachial-ankle pulse wave velocity (baPWV) might be independent predictors of development hypertension over short term, without any interaction; baPWV may directly associated with mediation arterial stiffness-related acceleration renal functional decline; second peak radial pressure waveform (SP2) also a significant predictor hypertension.In 1229 middle-aged...

It remains to be clarified whether liver stiffness is a direct risk factor for heart failure (HF) or its association with HF mediated by vascular damage. We conducted cross-sectional and prospective longitudinal studies examine fibrosis 4 score (FIB-4 score) directly associated the serum NT-pro-BNP levels arterial and/or abnormal central hemodynamics.In 3040 health Japanese subjects < 125 pg/ml, FIB-4 was calculated, levels, brachial-ankle pulse wave (baPWV) velocity radial augmentation...

The first asymmetric synthesis of trialkyl phosphates having stereogenic phosphorus atoms on the basis dynamic kinetic resolution using a chiral source in catalytic manner; achieved through stereospecific oxidation phosphite enantioselectively obtained by condensation racemic unsymmetrically substituted dialkyl phosphorochloridite and an alcohol amine as promoter.

The diastereoselective aldol reaction of tributyltin enolate cyclohexanone with benzaldehyde was studied in the presence a catalytic amount various metal triflates. highest anti selectivity observed Pd(OTf)2, while Zn(OTf)2 THF showed moderate syn selectivity. use (S,S)- i Pr-pybox 3 ⋅ Cu(OTf)2 complex as catalyst preferentially produced optically active adduct 84% ee.

The effect of age on the augmentation index (AI) differs between young adults and elderly, AI reaches a plateau after 60 years. We examined whether effects an elevation in blood pressure differ subjects with without high pressure, or AI. radial was measured 10,190 who were either healthy had hypertension (n = 5,477 men 4,743 women). In both sexes, phased increase could only be confirmed up to A systolic (SBP) SBP >170mm Hg. Among categorized within highest tertile, stepwise multivariable...

We determined whether any significant association exists between change in late systolic cardiac load with time, estimated by radial pressure waveform analysis, and development of hemodynamic stress individuals preserved function. Brachial-ankle pulse wave velocity, augmentation index (rAI), first peak the (SP1), at second (SP2 PP2), serum levels N-terminal fragment B-type natriuretic peptide (NT-proBNP) were measured start (first examination) end (second this 3-year study healthy Japanese...

Abstract Background Cardiac resynchronization therapy (CRT) reduces cardiac electrical dyssyncrhony and improves clinical outcomes in selected symptomatic patients with left ventricular (LV) systolic dysfunction. However, after conventional CRT (Bi-V) have residual dyssynchrony. multi-site pacing has gained attention to improve short-term outcome refractory BiV. long-term follow up is still uncertain. We evaluated the efficacy of triple-site stimulation (Tri-V), involving 2 LV lead...

AbstrctThis paper aims to explain and analyze the test results of fire behavior real-size bed mattress products when subjected an open flame burner system with a total heat supply 27 kW according ISO 12949 method. These were analyzed in terms release rate, height, temperature, flame-spread rate using equation. A normal without any retardant treatment has peak (HRR) more than 3 MW before 300 s. After ignition, only few minutes are allowable for evacuation occupants, making it important...

Fine diamond particles (from 0. 5 to 2μm) were successfully coated with silicon of 6. 6, 13. 8 and 20. 0vol% by PVD method. These sintered under 5. 5GPa at 1723K for 5h a cubic type ultrahigh pressure apparatus. Silicon carbide in each compact was formed between the during sintering acted as bonding material diamonds. The obtained sinter having 21. 8vol% fully densified showed very high hardness (about 9700 HV 1. 0) produced industrial usage.

Objective: Global cardiovascular risk stratification is essential in high-risk hypertensive patients. However, it uncertain how often the strategy executed real clinical practice. We sought to evaluate management of patients with coronary artery disease (CAD) using brachial-ankle pulse wave velocity (baPWV).Design and method: A total 851 CAD (age 65 ± 11) were enrolled baPWV measured every year (mean follow up periods 4.5 years). All subjects devided into two groups: optimal medical therapy...

Introduction: The underlying mechanisms of the association inflammation with development hypertension has not been clarified. Hypothesis: Inflammation affect via vascular and/or renal abnormalities. Methods: abnormalities, and such abnormalities elevation blood pressure were examined by analyzing longitudinal repeated-measures data using a linear mixed model (LMM) approach in 9-year prospective observational study. 3908 middle-aged Japanese employees construction company (aged 41 ± 9 years...

Objective: Obstructive sleep apnea (OSA) is an independent risk for cardiovascular disease. Apnea-hypopnea index (AHI) a marker the severity of OSA, and it also reflects damages. On other hand, Epworth Sleepiness Scale (ESS) clinical symptom OSA (sleepiness), has not been fully clarified ESS The present study was conducted to examine whether associated with damages OSA. Design method: In consecutive 1047 patients diagnosed as (AHI>5) by polysomnography, brachial-ankle pulse wave velocity...

Objective: Several cross sectional studies reported the association of arterial stiffness with calcium/phosphate metabolism in general population. But no longitudinal study has confirmed this association. This 3-years’ observation was conducted to examine between changes during period and serum calcium (Ca) phosphate (P) levels.Design method: Ca, P, brachial-ankle pulse wave velocity (baPWV) were measured 3-year interval 1735 middle-aged Japanese men (45 ± 9 years). Results: The...