A5036507987- Breast Cancer Treatment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diversity and Career in Medicine
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- Advanced Radiotherapy Techniques
- Global Cancer Incidence and Screening
- Advances in Oncology and Radiotherapy
- Cancer Treatment and Pharmacology
- Health and Medical Research Impacts
- Drug Transport and Resistance Mechanisms
- Protein Degradation and Inhibitors
- BRCA gene mutations in cancer
- Cancer Cells and Metastasis
- Economic and Financial Impacts of Cancer
- Cutaneous Melanoma Detection and Management
- Breast Lesions and Carcinomas
- Neuroendocrine Tumor Research Advances
- Patient-Provider Communication in Healthcare
- Effects of Radiation Exposure
- Biliary and Gastrointestinal Fistulas
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
University of Michigan
2016-2025
St. Luke's University Health Network
2024
Beth Israel Deaconess Medical Center
2024
Johns Hopkins University
2011-2024
Michigan Medicine
2004-2023
Michigan United
2022-2023
U-M Rogel Cancer Center
2003-2022
Michigan Center for Translational Pathology
2005-2022
United States Department of Veterans Affairs
2020
Memorial Sloan Kettering Cancer Center
2020
Young children with older siblings and those who attend day care are at increased risk for infections, which in turn may protect against the development of allergic diseases, including asthma. However, results studies examining relation between exposure to other subsequent asthma have been conflicting.
Background: Female physician-researchers do not achieve career success at the same rate as men. Differences in nonprofessional responsibilities may partially explain this gap. Objective: To investigate division of domestic labor by gender a motivated group early-career physician-researchers. Design: Nationwide postal survey between 2010 and 2011. Setting: United States. Participants: Physician recipients National Institutes Health K08 or K23 awards 2006 2009 with active academic affiliation...
This study assessed the extent to which sleep-disordered breathing (SDB), difficulty initiating and maintaining sleep (DIMS), excessive daytime sleepiness (EDS) were associated with impairment of quality life (QoL) using SF-36. Participants (n=5,816; mean age=63 years; 52.5% women) enrolled in nation-wide population-based Sleep Heart Health Study (SHHS) implemented investigate as a risk factor development cardiovascular disease. Each transformed SF-36 scale was analyzed independently...
Abstract Markers that reliably identify cancer stem cells (CSC) in ovarian could assist prognosis and improve strategies for therapy. CD133 is a reported marker of CSC. Aldehyde dehydrogenase (ALDH) activity CSC several solid tumors, but it has not been studied Here we report dual positivity ALDH defines compelling set All human tumors cell lines displayed activity. ALDH+ isolated from were chemoresistant preferentially grew compared with ALDH− cells, validating as lines. Notably, few 1,000...
It is unclear whether male and female physician researchers who perform similar work are currently paid equally.To determine salaries differ by gender in a relatively homogeneous cohort of and, if so, to these differences explained specialization, productivity, or other factors.A US nationwide postal survey was sent 2009-2010 assess the salary characteristics population physicians. From all 1853 recipients National Institutes Health (NIH) K08 K23 awards 2000-2003, we contacted 1729 were...
This survey study of recent National Institutes Health career development (K) award recipients assessed the proportion who reported gender bias and advantage sexual harrassment in their professional careers.
Abstract Purpose: The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and upregulated cancer stem cells (CSCs). GDC-0449 an oral small-molecule inhibitor the HH pathway. This study assessed effect GDC-0449–mediated inhibition paired biopsies, followed by combined treatment with gemcitabine, patients metastatic adenocarcinoma. Experimental Design: Twenty-five were enrolled which 23 underwent core biopsies at baseline following 3 weeks GDC-0449....
To evaluate the financial experiences of a racially and ethnically diverse cohort long-term breast cancer survivors (17% African American, 40% Latina) identified through population-based registries.Longitudinal study women diagnosed with nonmetastatic in 2005 to 2007 reported SEER registries metropolitan Los Angeles Detroit. We surveyed 3,133 approximately 9 months after diagnosis 4 years later. Multivariable models evaluated correlates self-reported decline status attributed experiencing at...
Abstract Purpose: Accumulating evidence supports the existence of breast cancer stem cells (BCSC), which are characterized by their capacity to self-renew and divide indefinitely resistance conventional therapies. The Notch pathway is important for cell renewal a potential target BCSC-directed therapy. Experimental Design: Using human tumorgraft studies, we evaluated impact gamma secretase inhibitors (GSI) on BCSC population efficacy combining GSI with docetaxel treatment. mouse experimental...
Purpose To explore aspects of mentoring that might influence medical faculty career satisfaction and to discover whether there are gender differences. Method In 2010–2011, the authors surveyed 1,708 clinician–researchers who received (in 2006–2009) National Institutes Health K08 K23 awards, which provided for development. The compared, by gender, development nature relationships, mentor characteristics, extent in various roles, with mentoring. They evaluated associations between using...
Female physicians may experience unique challenges regarding fertility and family planning. We sought to determine childbearing patterns decision-making among American female physicians.In 2012-2013, we surveyed a random sample of 600 who graduated medical school between 1995 2000. Primary outcome measures included history, reflections decision-making, perceptions workplace support, estimations potential.Response rate was 54.5% (327/600). A majority (82.0%) the were parents, 77.4% had...
BACKGROUND. Epidemiologic studies suggest that metformin has antitumor effects. Laboratory indicate impacts cancer stem-like cells (CSCs). As part of a phase II trial, we evaluated the impact on CSC number and carcinoma-associated mesenchymal stem (CA-MSCs) clinical outcomes in nondiabetic patients with advanced-stage epithelial ovarian (EOC).
PURPOSE Multiple studies have shown a low risk of ipsilateral breast events (IBEs) or other recurrences for selected patients age 65-70 years older with stage I cancers treated breast-conserving surgery (BCS) and endocrine therapy (ET) without adjuvant radiotherapy. We sought to evaluate whether younger postmenopausal could also be successfully radiation therapy, adding genomic assay classic selection factors. METHODS Postmenopausal 50-69 pT1N0 unifocal invasive cancer margins ≥2 mm after...
Abstract Background Ginger ( Zingiber officinale Rosc) is a natural dietary component with antioxidant and anticarcinogenic properties. The ginger [6]-gingerol has been shown to exert anti-inflammatory effects through mediation of NF-κB. NF-κB can be constitutively activated in epithelial ovarian cancer cells may contribute towards increased transcription translation angiogenic factors. In the present study, we investigated effect on tumor cell growth modulation factors vitro . Methods major...
Background: Concerns have been raised about the career pipeline in academic medicine, including whether women with a demonstrated commitment to research succeed at same rate as male colleagues. Objective: To determine subsequent success of recipients National Institutes Health (NIH) development awards. Setting: United States. Participants: 2784 2799 (99.5%) K08 and K23 awards for whom sex could be ascertained from NIH Computer Retrieval Information on Scientific Projects database other...
In addition to Breslow depth, the authors previously described how increasing mitotic rate and decreasing age predicted sentinel lymph node (SLN) metastases in patients with melanoma. The objectives of current study were verify those previous results create a prediction model for better selection which melanoma should undergo SLN biopsy.The reviewed 1130 consecutive prospective database who underwent successful biopsy. After eliminating aged <16 years had melanomas that measured <1 mm, 910...
BACKGROUND The purpose of this study was to evaluate preoperative treatment with full‐dose gemcitabine, oxaliplatin, and radiation therapy (RT) in patients localized pancreatic cancer. METHODS Eligibility included confirmation adenocarcinoma, resectable or borderline disease, a performance status ≤2, adequate organ function. Treatment consisted two 28‐day cycles gemcitabine (1 g/m 2 over 30 minutes on days 1, 8, 15) oxaliplatin (85 mg/m 1 RT during cycle (30 Gray [Gy] 2‐Gy fractions)....