A5078801019- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Shoulder and Clavicle Injuries
- Hip and Femur Fractures
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Knee injuries and reconstruction techniques
- Cardiac, Anesthesia and Surgical Outcomes
Rush University Medical Center
2024-2025
University of California, Los Angeles
2021-2024
Bacterial biofilms on orthopedic implants are resistant to the host immune response and traditional systemic antibiotics. Novel therapies needed improve patient outcomes. TRL1068 is a human monoclonal antibody (mAb) against biofilm anchoring protein. For assessment of this agent in an implant infection model, efficacy was measured by reduction bacterial burden Staphylococcus aureus, most common pathogen for prosthetic joint infections (PJI). Systemic treatment with disrupting mAb conjunction...
Aims Delayed postoperative inoculation of orthopaedic implants with persistent wound drainage or bacterial seeding a haematoma can result in periprosthetic joint infection (PJI). The aim this vivo study was to compare the efficacy vancomycin powder vancomycin-eluting calcium sulphate beads preventing PJI due delayed inoculation. Methods A mouse model knee used. Mice were randomized into groups intervention at time surgery (postoperative day (POD) 0): sterile control (SC; n = 6); infected...
Introduction Periprosthetic joint infection (PJI) represents a devastating complication of total arthroplasty associated with significant morbidity and mortality. Literature suggests possible higher incidence periprosthetic in patients rheumatoid arthritis (RA). There is, however, no consensus on this purported risk nor well-defined mechanism. This study investigates how collagen-induced (CIA), validated animal model RA, impacts infectious burden well-established PJI. Methods Control mice...
e24061 Background: Pathologic and impending fractures commonly occur in the proximal femur, patients may be prescribed opioids prior to surgery often require for postoperative pain relief. This study compared opiate usage ambulatory functional status with versus pathologic femur. Methods: was a retrospective review of using postoperatively who underwent internal fixation or fracture between 2016 2022. Preoperative opioid as well ambulation risk factors at three six months associated use were...
Abstract Introduction Periprosthetic joint infection (PJI) represents a devastating complication of total arthroplasty associated with significant morbidity and mortality. Literature suggests possible higher incidence periprosthetic in patients rheumatoid arthritis (RA). There is, however, no consensus on this relative risk nor well-defined mechanism purported risk. This study investigates how collagen-induced (CIA), validated animal model RA, impacts infectious burden well-established PJI....