A5052903117- Diabetes Management and Research
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Telomeres, Telomerase, and Senescence
- Multiple Myeloma Research and Treatments
- PARP inhibition in cancer therapy
- Cancer-related Molecular Pathways
- Alcohol Consumption and Health Effects
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Advanced biosensing and bioanalysis techniques
- Drug-Induced Hepatotoxicity and Protection
- Gallbladder and Bile Duct Disorders
- Metabolism and Genetic Disorders
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Breast Cancer Therapies
- Stroke Rehabilitation and Recovery
- Genetics and Neurodevelopmental Disorders
- Acute Myeloid Leukemia Research
- Single-cell and spatial transcriptomics
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
Research Institute for Work, Technology and Culture
2023
University of California, Riverside
2023
Universitätsklinikum Tübingen
2015-2023
MRC London Institute of Medical Sciences
2018-2022
Imperial College London
2018-2021
The University of Texas MD Anderson Cancer Center
2014
German Cancer Research Center
2014
Heidelberg University
2014
Institute for Rheumatic Diseases (Japan)
1955
Deleterious ATM alterations are found in metastatic prostate cancer (PC); PARP inhibition has antitumour activity against this subset, but only some loss PCs respond. To characterise ATM-deficient lethal PC and to study synthetic therapeutic strategies for subset. We studied advanced biopsies using validated immunohistochemical (IHC) next-generation sequencing (NGS) assays. In vitro cell line models modified CRISPR-Cas9 impair function were generated used drug-sensitivity functional assays,...
<title>Abstract</title> <bold>Background:</bold> Children with X-linked hypophosphatemia (XLH) present rickets, leg deformities, and growth failure. Bone stability depends on balanced bone in both, length width. Data body proportions, including transverse dimensions, children XLH treated phosphate supplements active vitamin D is lacking. <bold>Methods:</bold> Six major dimensions of the trunk extremities, frame index (FI), i.e. ratio between bicondylar humerus diameter height, were measured...
Senescence is a key barrier to neoplastic transformation. To identify senescence regulators relevant cancer, we screened genome-wide shRNA library. Here, describe exportin 7 (XPO7) as novel regulator of and validate its function in telomere-induced, replicative, oncogene-induced (OIS). XPO7 bidirectional transporter that regulates the nuclear-cytoplasmic shuttling broad range substrates. Depletion results reduced levels TCF3 an impaired induction cyclin-dependent kinase inhibitor p21
// Verena Wagner 1,* , Dirk Hose 2,3,* Anja Seckinger 2 Ludmila Weiz 1 Tobias Meißner Thiery Rème 4 Iris Breitkreutz 1,3 Klaus Podar 3 Anthony D. Ho Hartmut Goldschmidt 2,3 Alwin Krämer 5 Bernard Klein 4,6 and Marc S. Raab 1,2 Max-Eder Group Experimental Therapies for Hematologic Malignancies, German Cancer Research Center (DKFZ) Dept. of Internal Medicine V, University Heidelberg, Germany National Tumor Diseases, INSERM U1040, Montpellier, France Clinical Cooperation Unit Molecular...
A series of empirical pilot studies, performed during workshops at meetings the American Academy Psychiatry and Law (AAPL), examining various aspects attorney-expert witness relationship are presented their implications discussed. The author calls for further investigation a topic that--although constantly feature discussion among both experts attorneys--lacks extensive investigation.
Neuroendocrine neoplasms (NENs) encompass a heterogeneous group of tumors. Whereas low-grade neuroendocrine tumors (NETs) are histologically well-differentiated, highly aggressive carcinomas (NECs) characterized by high proliferation rate and worse clinical outcome. Since most NEN patients need monitoring tumor progress response to treatment for long period time, especially in metastatic disease, reliable, dynamic, easy-to-assess biomarkers needed. In this prospective study, we identified...
History and admission findings: We report on a 76-year-old man presenting with painless jaundice who developed dialysis-dependent acute kidney injury. Investigations: Biliary tract was examined endoscopy, in addition biopsy performed. Diagnosis, treatment course: A stenosing process could be seen the biliary tract, leading to stent implantation. However, did not resolve. Kidney revealed bile casts indicating cholemic nephropathy. After switch of concomitant medication, hyperbilirubinemia...
Die Verbesserung der Versorgung von Kindern und Jugendlichen mit Diabetes mellitus ist eine wesentliche Aufgabe Arbeitsgemeinschaft für Pädiatrische Diabetologie (AGPD).
Recurrent Pyogenic Cholangitis (RPC) or Primary Hepatolithiasis is a common disease of the biliary tract in Asia, whereas it usually not seen Europeans. With increasing global mobility, will be encountered Europe more frequently, too. It should therefore considered as differential diagnosis patients from endemic countries with recurrent symptoms cholestasis/cholangitis and bile duct dilations, strictures hepatolithiasis. In this case report, we present history 37-year old patient Sri Lanka...
Die Verbesserung der Versorgung von Kindern und Jugendlichen mit Diabetes mellitus ist eine wesentliche Aufgabe Arbeitsgemeinschaft für Pädiatrische Diabetologie (AGPD).
Einleitung Mutiertes Ras (HRAS, NRAS oder KRAS) ist eines der wichtigsten Onkogene bei gastrointestinalen Tumoren und ein prognostisch ungünstiger Faktor. Die Ras-induzierte Tumorigenese verläuft in mehreren Schritten. Aktivierung von onkogenem führt zunächst zur Induktion Seneszenz prämalignen Läsionen. Durch zusätzliche genetische Veränderungen (z.B. Inaktivierung p16INK4A p53) kommt es Entstehung malignen Tumoren.
Einleitung Unerkannter und fortwährender schädlicher Alkoholkonsum nach Lebertransplantation (LTx) kann gravierende Auswirkungen auf Transplantat- Patientenüberleben haben. Ethylglucuronid (EtG) Phosphatidylethanol (PEth) können als direkte Metaboliten von Alkohol ggf. frühzeitig einen objektivierbaren Hinweis für schädlichen liefern.
Die Verbesserung der Versorgung von Kindern und Jugendlichen mit Diabetes mellitus ist eine wesentliche Aufgabe Arbeitsgemeinschaft für Pädiatrische Diabetologie (AGPD).