A5047462696- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Family Support in Illness
- Palliative Care and End-of-Life Issues
- Infant Development and Preterm Care
- Ethics and Legal Issues in Pediatric Healthcare
- Adolescent and Pediatric Healthcare
- Neuroblastoma Research and Treatments
- Psychology, Coaching, and Therapy
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- Family and Disability Support Research
- Pediatric Pain Management Techniques
- Child and Adolescent Health
- Cerebral Palsy and Movement Disorders
- Vestibular and auditory disorders
- Family and Patient Care in Intensive Care Units
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Cancer survivorship and care
- Mental Health and Patient Involvement
- Cancer-related cognitive impairment studies
Medical University of Vienna
2015-2025
Comprehensive Cancer Center Vienna
2017-2025
Vienna General Hospital
2024
European Society for Paediatric Oncology
2023-2024
Universitätsklinik für Kinder und Jugendpsychiatrie
2013-2023
University of Hong Kong
2023
Community College of Rhode Island
2023
St Anna Children's Hospital
2023
Statistics Austria
2023
MODUL University Vienna
2021
Abstract Background Median survival time of recurrent embryonal brain tumors is short regardless salvage chemotherapy used. An evolving alternative approach to conventional target neovascularization by interfering with tumor angiogenesis at various levels. Procedure From November 2006 December 2010, 16 patients (median age: 9 years) (9 first, 7 multiple) were treated an antiangiogenic multidrug combination regimen (bevacizumab, thalidomide, celecoxib, fenofibrate, etoposide, and...
Abstract Atypical teratoid rhabdoid tumors ( ATRT s) are recently defined highly aggressive embryonal central nervous system with a poor prognosis and no definitive guidelines for treatment. We report on the importance of an initial correct diagnosis disease‐specific therapy outcome in 22 consecutive patients propose new treatment strategy. From 1992 to 2012, nine initially diagnosed correctly as (cohort A, median age 24 months) were treated according intensive multimodal regimen MUV ‐ )...
Importance Medulloblastoma recurrence in patients who have previously received irradiation has a dismal prognosis and lacks standard salvage regimen. Objective To evaluate the response rate of pediatric with medulloblastoma using an antiangiogenic metronomic combinatorial approach (Medulloblastoma European Multitarget Metronomic Anti-Angiogenic Trial [MEMMAT]). Design, Setting, Participants This phase 2, investigator-initiated, multicenter nonrandomized controlled trial assessed 40 relapsed...
Objective: Previous studies differ regarding the long-term effects of surgically removed pediatric cerebellar pilocytic astrocytomas (CPA). Thus, aim this study was to investigate impact on neurocognitive and functional outcome analyze age as an influencing factor. Methods: Fourteen CPA patients were compared norm a group 14 high-achieving peers cognitive functioning, health-related quality life (HRQoL), stress regulation. Mean follow-up time after diagnosis 13.29 years (range: 3–21 years)....
Paediatric palliative care aims to support children and young people with life-limiting or life-threatening conditions, their families, from the time of diagnosis. Early integration within oncology has been recognised as having benefits for all involved, whatever outcome may be. Through improved communication advance planning, it enables user-centred care, where concerns about quality life, preferences values are given same relevance cutting-edge therapy. Challenges paediatric include...
Abstract Background Patient and public involvement engagement (PPIE) in healthcare research is crucial for effectively addressing patients' needs setting appropriate priorities. However, there a lack of awareness adequate methods practicing PPIE, especially vulnerable groups like childhood cancer survivors. Aims This project aimed to develop evaluate actively involve pediatric oncological patients, survivors, their caregivers developing relevant questions practical study designs. Methods...
Over the past decades, many studies used global outcome measures like IQ when reporting cognitive of pediatric brain tumor patients, assuming that intelligence is a singular and homogeneous construct. In contrast, especially in clinical neuropsychology, assessment interpretation distinct neurocognitive domains emerged as standard. By definition, full scale (FIQ) score attempting to measure intelligence. It established by calculating average performance number subtests. Therefore, FIQ depends...
Abstract Background Public and Patient Involvement Engagement (PPIE) in research is still a poorly understood infrequently practiced concept, although the literature stresses clear benefits for quality of care as well patient satisfaction empowerment. Aim The presently described project aimed at using different PPIE methods to evaluate current state knowledge about attitude toward among stakeholders pediatric oncology Europe. Based on findings tailored training tool directed will be...
The goal of this study was to evaluate the feasibility, benefit, and safety awake brain surgery (ABS) intraoperative language mapping in children adolescents with structural epilepsies. Whereas ABS is an established method monitor function adults intraoperatively, reports are scarce.A retrospective chart review pediatric patients ≤ 18 years age who underwent cortical for supratentorial tumors nontumoral epileptogenic lesions between 2008 2019 conducted. authors evaluated global intellectual...
Zusammenfassung Gesundheitskompetenz spielt eine entscheidende Rolle für pädiatrische Patient:innen und bedeutet, Gesundheit bzw. Krankheit zu verstehen, erhalten verbessern. Sie ist assoziiert mit effektivem Coping Lebensqualität. Eine adaptierte Version der Gesundheitskompetenzskala wurde genutzt, um Gesundheitsüberzeugungen Copingstrategien von 197 hochgesunden Kindern Jugendlichen deren Eltern erfassen. Die Ergebnisse zeigen hohe Einschätzungen seitens soziale Einschränkungen (90,1 %) im...
Background Integrating pediatric palliative care (PPC) into oncology standard is essential. Therefore, it important to assess physicians’ knowledge and perceptions of PPC optimize its practice. Objective To evaluate the knowledge, comfort levels, perspectives physicians regarding timing perceived barriers integrating cancer across Europe. Design The Assessing Doctors’ Attitudes on Palliative Treatment (ADAPT) survey, originally developed for other global regions, was culturally contextually...
Abstract Aim The aim of this study was to investigate specific attentional components in preterm born children who had not yet started school. Methods Between January and December 2011, we assessed 52 full‐term aged between five years months six two months, comparable age gender, at the Medical University Vienna. Different were evaluated through selected subtests Test Attentional Performance German version Wechsler Intelligence Scale for Children. Each child's behaviour also using parental...
While it has been shown that cerebellar tumor lesions have an impact on cognitive functions, the extent to which they shape distant neuronal pathways is still largely undescribed. Thus, present neuroimaging study was designed investigate different aspects of function and their correlates in patients after childhood surgery. An alertness task, a working memory task incompatibility were performed by 11 surgery 17 healthy controls. Neuronal as reflected alterations functional networks during...
The aim of this case-control study was to investigate the severity cerebellar cognitive affective syndrome (CCAS) in patients treated for pediatric posterior fossa tumors (PFT) and evaluate its diagnostic validity predictive value long-term effects.Using neuropsychological test data from 56 with PFT (average age: 14 years), deficits CCAS core areas (executive functions, verbal visuospatial abilities emotions/behaviour) examined. Neuropsychological academic outcomes were compared two control...
Abstract PDGFRA is commonly altered in pediatric and young adult high-grade gliomas (pHGGs) including histone 3 lysine 27-mutated diffuse midline (H3K27M DMG), a fatal disease with no current options for cure. We performed comprehensive genomic transcriptomic analyses of n=259 glioma cases which revealed alterations ~15% patients. H3K27M DMGs had significantly higher expression compared to H3 wild-type tumors regardless alteration. Tumors gene amplification demonstrated elevated both pHGGs...
Abstract Background Psychosocial guidelines and standards systematically describe stressors resources in particularly challenging situations hence serve as a basis for interventions to achieve defined psychosocial goals. Despite fundamental principles methods, the quality of provided care varies considerably depending on setting, provision, profession. The purpose present protocol is illustrate development evaluation standardized psychological intervention “My Logbook”, practical guide...
Survivors of pediatric central nervous system (CNS) cancer are at risk for long term sequelae concerning school participation. Therefore, the purpose study was to develop and evaluate a school-participation questionnaire patients parents based on International Classification Functioning, Disability Health (ICF). The items School Participation Scales-24/7 (S-PS-24/7) meet different functions, activities participation aspects, as well environmental factors listed in ICF, using everyday...