A5007306335- Force Microscopy Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Molecular Junctions and Nanostructures
- Music Technology and Sound Studies
- Tactile and Sensory Interactions
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Music Perception
- Lipid Membrane Structure and Behavior
- Motor Control and Adaptation
RIKEN Center for Biosystems Dynamics Research
2023
Osaka University
2020-2023
National Institute of Information and Communications Technology
2023
Ube Frontier University
2020
Mechanical forces are critical for regulating many biological processes such as cell differentiation, proliferation, and death. Probing the continuously changing molecular force through integrin receptors provides insights into mechanism of rigidity sensing in cells; however, information is still limited. Here, we built a coil-shaped DNA origami (DNA nanospring, NS) sensor that reports dynamic motion single integrins well magnitude orientation living cells. We monitored extension with...
Muscle energetics reflects the ability of myosin motors to convert chemical energy into mechanical energy. How this process takes place remains one most elusive questions in field. Here, we combined experimental measurements vitro sliding velocity based on DNA-origami built filaments carrying myosins with different lever arm length and Monte Carlo simulations a model which accounts for three basic components: (i) geometrical hindrance, (ii) mechano-sensing mechanism, (iii) biased kinetics...
Abstract Muscle energetics reflects the ability of myosin motors to convert chemical energy into mechanical energy. How this process takes place remains one most elusive questions in field. Here we combined experimental measurements vitro sliding velocity based on DNA-origami built filaments carrying myosins with different lever arm length and simulations a Monte-Carlo model which accounts for three basic components: (i) geometrical hindrance, (ii) mechano-sensing mechanism, (iii) biased...
Being able to play a musical instrument requires complicated sensorimotor learning. Many beginners give up practicing Piano or Guitar because they require long time of practice overcome difficulties. It is not possible and perform anytime anywhere. We fundamentally rethought how the device software should be, tested hypothesis that new interface "ParoTone" with music game style notation, one-to-one correspondence between 5 lanes fingers octave shifts, playing chords one button can balance...
Muscle myosins work in motor ensembles and must adapt their power stroke response to mechanical actions by surrounding motors. Understanding the coordination of strokes is essential for bridging microscopic molecular functions macroscopic muscle contractions, but details this phenomenon remain elusive. Here we used high-speed atomic force microscopy visualize individual dynamics (lever-arm swing) myosin head bound actin DNA origami–based synthetic thick filaments. We observed spatially local...