A5028822061- Phytochemical compounds biological activities
- Plant chemical constituents analysis
- Chemical synthesis and alkaloids
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Essential Oils and Antimicrobial Activity
- Advanced Synthetic Organic Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Alkaloids: synthesis and pharmacology
- Plant Toxicity and Pharmacological Properties
- Synthetic Organic Chemistry Methods
- Plant Pathogens and Fungal Diseases
- Herbal Medicine Research Studies
- Insect Pest Control Strategies
- Fungal Plant Pathogen Control
- Synthesis of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive natural compounds
- Plant biochemistry and biosynthesis
- Fungal Biology and Applications
- Synthesis and Biological Activity
- Plant-derived Lignans Synthesis and Bioactivity
- Analytical Chemistry and Chromatography
- Quinazolinone synthesis and applications
University of Vienna
2010-2025
Chinese University of Hong Kong
2006-2010
Kasetsart University
2000-2009
Hong Kong Jockey Club
2006
Czech Academy of Sciences, Institute of Botany
1986-2004
University of Graz
1969-2004
FH Campus Wien
1988
Leiden University
1982
Technische Universität Berlin
1977
Antifungal testing of filamentous fungi generally suffers from incomparability results. In order to illustrate this problem, the polyacetylene falcarindiol and naphthoquinone juglone, two known antifungal natural products, were assayed in various dilution diffusion bioassays against three selected microfungi, Botrytis cinerea, Cladosporium herbarum Fusarium avenaceum. Broth microdilution, based on 96-well microtitre plate format, can be scored by direct biochemical methods. As examples,...
Disablement of cell death programs in cancer cells contributes to drug resistance and some cases has been associated with altered translational control. As eukaryotic translation initiation factor 4E (eIF4E) cooperates c-Myc during lymphomagenesis, induces resistance, is a genetic modifier the rapamycin response, we have investigated effect dysregulation ribosome recruitment phase on tumor progression chemosensitivity. eIF4E subunit eIF4F, complex that stimulates by delivering DEAD-box RNA...
Background Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and vivo inhibit translation initiation. They have been shown to modulate eIF4A, DEAD-box RNA helicase subunit eukaryotic initiation factor (eIF) 4F complex, complex stimulates ribosome recruitment during One flavagline, silvestrol, is capable modulating chemosensitivity mechanism-based mouse model. Methodology/Principal Findings Among number flavagline members tested...
Cyclotides are a unique class of ribosomally synthesized cysteine-rich miniproteins characterized by head-to-tail cyclized backbone and three conserved disulfide-bonds in knotted arrangement. Originally they were discovered the coffee-family plant Oldenlandia affinis (Rubiaceae) have since been identified several species violet, cucurbit, pea, potato, grass families. However, identification novel cyclotide-containing still is major challenge due to lack rapid accurate analytical workflow...
Fifteen new stilbenoids including 11 phenylbenzofurans, the stemofurans A-K (1-11), and four dihydrostilbenes, stilbostemins A (15), C (17), E (19), F (20), were isolated identified from a methanolic extract of Stemona collinsae roots together with five known derivatives, stilbenes pinosylvin (13) 4'-methylpinosylvin (14), B (16) D (18), dihydrophenanthrene racemosol (12) as well (+)-sesamin, coniferyl alcohol, stigmasterol. Bioautographic tests Cladosporium herbarum displayed antifungal...
Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in vitro cyclooxygenase (sheep seminal microsomes) 5-lipoxygenase (porcine leukocytes) assays. Activity appeared depend on the particular structure of alkamides.
On the basis of chronic feeding bioassays with neonate larvae Spodoptera littoralis reared on an artificial diet, methanolic leaf and root extracts from Stemona collinsae displayed very high insect toxicity compared to those two Aglaia species, a commercial Pyrethrum extract, azadirachtin, whereas S. tuberosa demonstrated low activity in roots no leaves. Beyond that, disk choice tests against fifth instar larvae, showed strong antifeedant activity, was characterized by remarkable repellency....
Stemona alkaloids represent a unique class of natural products exclusively known from the three genera Stemona, Stichoneuron, and Croomia monocotyledonous family Stemonaceae. Structurally they are characterized by central pyrroloazepine core usually linked with two butyrolactone rings. The great diversity, comprising 215 derivatives, is created formation additional C–C linkages oxygen bridges together ring cleavages eliminations lactone Based on biosynthetic considerations can be grouped...
Seven new naturally occurring 3-butylisocoumarins were isolated and identified from lipophilic extracts of aerial as well underground organs: corfin (17) 3'-hydroxycorfin (18) the roots Chamaemelum mixtum (−)-(R)-2'-methoxydihydroartemidin (5), (+)-(S,R)-epoxyartemidin (6a), dracumerin (12), (+)-(R)-(E)-3'-hydroxyartemidin (13), capillarin isovalerate (20) various organs Artemisia dracunculus (tarragon). Furthermore, six known derivatives, artemidiol (7), (E/Z)-artemidin (11), (19),...
Twelve new derivatives of bisamides [piriferinol (5), edulimide (7)], lignans [lariciresinol acetat (10)], triterpenes [4-bis-norcycloartane-type (11a, 12a+b, 13a+b)], cyclopenta[b]benzofurans [pannellin (15), pannellin 1-O-acetate (16), 3'-methoxypannellin (17)], and an aromatic butyrolactone [aglalactone (18)] were isolated identified from lipophilic leaf, stem, root extracts Aglaia spp. elaeagnoidea, edulis, grandis, silvestris, tomentosa. Two (flavaglines), (15) displayed very strong...
Abstract: Sequences of the plastid DNA atp B/ rbc L intergenic spacer and rps16 intron from 23 genera 47 species Rutaceae were used to resolve phylogenetic relationships in subfamily Aurantioideae. According these, is monophyletic, but its classical subdivision into tribes Clauseneae Citreae only justified if genus Murraya s.s. (exclusive segregated as Bergera , e.g., koenigii M. siamensis ) Merrillia are transferred s.l. This conclusion also well supported by phytochemistry, demonstrating...
Eight flavaglines, six cyclopenta[b]benzofurans, a cyclopenta[bc]benzopyran, and benzo[b]oxepine, together with an aromatic butyrolactone were isolated from Aglaia odorata, A. elaeagnoidea, edulis (Meliaceae) tested against the three plant pathogens Pyricularia grisea, Fusarium avenaceum, Alternaria citri for antifungal properties. Using microdilution technique linked digital image analysis of germ tubes, benzofurans displayed strong activity, whereas benzopyran, benzoxepine, inactive at...