A5013608005- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- T-cell and B-cell Immunology
- Liver physiology and pathology
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
Hiroshima University
2015-2025
Kure Medical Center
2016-2025
National Hospital Organization
2016-2025
Hiroshima City Asa Citizens Hospital
2023
Hiroshima University Hospital
2008-2017
Higashihiroshima Medical Center
2017
Japan Society for the Promotion of Science
2015
Creative Commons
2015
University hospital Medical Information Network
2015
American Gastroenterological Association
2011
After liver transplantation in HCV-infected patients, the virus load inevitably exceeds pre-transplantation levels. This phenomenon reflects suppression of host-effector immune responses that control HCV replication by immunosuppressive drugs used to prevent rejection transplanted liver. Here, we describe an adoptive immunotherapy approach, using lymphocytes extracted from allograft perfusate (termed herein allograft–derived lymphocytes), which includes abundance NK/NKT cells mounted...
Clinicopathologic features of poorly differentiated hepatocellular carcinoma (HCC) have not been elucidated. The purpose this study was to clarify the characteristics HCC in hepatectomized patients.From 1986 2001, 354 patients underwent curative hepatectomy our institution and were prospectively followed. Histological examinations revealed 43 well-differentiated tumors, 273 moderately 38 tumors. factors outcomes after compared statistically.Only serum alpha-fetoprotein level significantly...
<i>Background:</i> Splenectomy is gaining increasing importance for cirrhotic patients with hypersplenism. However, its safety and efficacy chronic liver disease remain unclear. <i>Methods:</i> We retrospectively examined the medical records of 38 consecutive who underwent splenectomy or simultaneous hepatectomy hepatocellular carcinoma. <i>Results:</i> White blood cell platelet counts significantly increased 3 months after splenectomy. Serum levels total...
Transmembrane protease serine 4 (TMPRSS4) is a member of the type II transmembrane family known to be upregulated in many malignancies. We previously showed that TMPRSS4 may prognostic biomarker and therapeutic target for gastric cancer (GC), especially stage III. In this retrospective study conducted at 10 institutions, all 325 patients underwent R0 resection involving D2 lymph node dissection. expression was examined using immunohistochemical analysis. 44.9% participants. The 5-year...
Abstract Background and Aim: We have reported genetically-engineered mouse models for colonic neoplasia by using our novel CDX2P-Cre mice, in which Cre is restrictedly expressed epithelial cells. Although tumors are generated CDX2P-Cre;Apcflox/+ (CPC;Apc) mice with highly penetrant rate, greater number deeper invasion of were observed CDX2P-Cre;Apcflox/+;Ptenflox/+ (CPC;ApcPten), possibly resulting from haploinsufficiency Pten gene. also confirmed shorter lifespan CPC;ApcPten than that...
Background. To monitor antidonor alloreactivity for accurate diagnosis of acute rejection after living-donor liver transplantation (LDLT), we used a mixed lymphocyte reaction (MLR) assay using an intracellular fluorescent dye carboxyfluorescein diacetate succimidyl ester (CFSE)-labeling technique (CFSE-MLR) in 29 consecutive patients who underwent adult-to-adult LDLT. Methods. For developed moderate or severe disorders function, CFSE-MLR was performed together with needle biopsy the...
This study was designed to evaluate the efficacy of hepatic arterial infusion 5-fluorouracil (5-FU) and cisplatin (CDDP) for unresectable or recurrent hepatocellular carcinoma (HCC) with tumor thrombus trunk first branches portal vein (PVTT).Seven HCC patients PVTT were enrolled in this study. A one-week course chemotherapy consisted intraarterial administration CDDP (10 mg on days 1-5) 1 h 5-FU (250 24 h, followed by cessation subsequent 2 (days 6 7). Three more sequential courses given...
Background The purpose of this study was to evaluate both safety diet-treated donors and the feasibility their use for living-donor liver transplantation (LDLT). Methods A total 128 living were enrolled in between April 2003 March 2010. Of them, 41 diagnosed with hepatic steatosis at initial consultation. Donor selection based on findings biopsy accompanied normalization function tests after diet treatment consisting an 800 1400 kcal/day a 100 400 exercise without drug treatment, targeting...
Fatty liver (FL) is associated with development of hepatocellular carcinoma (HCC). However, whether FL itself promotes the progression HCC unclear. We recently found that hepatic stellate cells (HSCs) were prominently activated in steatotic liver. Here, we investigated livers promote and HSCs are progression. implanted rat into diet‐induced rats via portal vein injection. Thereafter, co‐implanted subcutaneously nude rats. Migration proliferation measured, activation ERK Akt these was...
Abstract Background The preferred choice between surgical treatment and radiofrequency ablation (RFA) for the of small resectable hepatocelluar carcinoma (HCC) has become a subject debate. Methods We compared results hepatic resection (n = 199) with those RFA 87), which 69 patients were treated transcatheter arterial chemoembolization followed by RFA, 286 3 or fewer nodules, none exceeded cm in diameter at Hiroshima University Hospital. Results In subgroup analysis single HCC tumor size...
Posthepatectomy liver failure (PHLF) is a serious complication associated with high mortality rates. Machine learning (ML) has rapidly developed and may outperform traditional models in predicting PHLF patients who have undergone hepatectomy. This study aimed to predict using ML compare its performance that of scoring systems.