A5027983515- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Nanoparticles: synthesis and applications
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Renal cell carcinoma treatment
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Migraine and Headache Studies
- Renal and related cancers
- Diabetes Treatment and Management
- Peroxisome Proliferator-Activated Receptors
- Ion Transport and Channel Regulation
- Neuropeptides and Animal Physiology
- Noise Effects and Management
- Antioxidant Activity and Oxidative Stress
- Nutritional Studies and Diet
- Telomeres, Telomerase, and Senescence
- Diet and metabolism studies
- Trigeminal Neuralgia and Treatments
- Exercise and Physiological Responses
- Heme Oxygenase-1 and Carbon Monoxide
- Vitamin C and Antioxidants Research
ALK-Abelló (Denmark)
2025
Gubra (Denmark)
2023-2025
University of Copenhagen
2014-2022
Novo Nordisk (Denmark)
2022
Danish Cancer Society
2011-2016
Roskilde University
2011
Exercise-induced oxidative stress is instrumental in achieving the health benefits from regular exercise. Therefore, inappropriate use of fruit-derived products (commonly applied as prophalytic antioxidants) may counteract positive effects Using human exercise and cellular models we found that 1) blackcurrant supplementation suppressed exercise-induced stress, e.g., plasma carbonyls (0.9 ± 0.1 vs. 0.6 nmol/mg protein, placebo blackcurrant), 2) preincubation THP-1 cells with an...
Exposure to ambient air particulate matter (PM) has been linked decline in pulmonary function and cardiovascular events possibly through inflammation. Little is known about individual exposure ultrafine particles (UFP) inside outside modern homes associated health-related effects. Associations between vascular lung function, inflammation markers terms of particle number concentration (PNC; d = 10-300 nm) were studied a cross-sectional design with personal home indoor monitoring the Western...
Vegetable carbon (E153) and titanium dioxide (E171) are widely used as black white food colour additives. The aim of this study was to assess gastrointestinal tight junction systemic genotoxic effects in rats following exposure E153 E171 for 10 weeks by oral gavage once a week. expression proteins assessed intestinal tissues. Levels DNA strand breaks, oxidatively damaged telomere length were secondary organs. Hydrodynamic suspensions E173 indicated mean particles sizes 230 270 nm,...
Migraine is a debilitating headache disorder. The disease has neurovascular origin and migraine attacks can be elicited by vasodilative neuropeptides such as alpha calcitonin gene-related peptide (αCGRP). Antagonizing CGRP actions in patients proven clinically efficient. Here, we present pipeline for development of peptide-based hCGRP receptor antagonist with increased half-life capable antagonising the vasodilatory effect hαCGRP. A series hαCGRP8-37 analogues carrying C18-or C20-diacid...
Abstract Background Extensive preclinical research aims to develop novel therapeutics for myocardial fibrosis (MF), a condition marked by collagen accumulation that impairs cardiac function. MF is particularly relevant in heart failure with preserved ejection fraction (HFpEF), growing clinical challenge limited treatment options. However, current methods quantifying mouse models struggle accurately capture its heterogeneous regional distribution, creating significant barrier reliably...
Humans are continuously exposed to particles in the gastrointestinal tract. Exposure may occur directly through ingestion of via food or indirectly by removal inhaled material from airways mucociliary clearance system. We examined effects food-grade particle exposure on vasomotor function and systemic oxidative stress an ex vivo study intragastrically rats. In study, aorta rings naïve Sprague-Dawley rats were for 30 min TiO2 (E171), benchmark (Aeroxide P25), vegetable carbon (E153) black...
Inflammation and oxidative stress are considered the main drivers of vasomotor dysfunction progression atherosclerosis after inhalation particulate matter. In addition, new studies have shown that particle exposure can induce level bioactive mediators in serum, driving vascular- systemic toxicity. We aimed to investigate if pulmonary inflammation would accelerate nanoparticle-induced atherosclerotic plaque Apolipoprotein E knockout (ApoE-/-) mice. ApoE -/- mice were exposed vehicle, 8.53 or...
Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism thought to be sex-hormone driven. In vitro observational studies suggest a involving peroxisome proliferator-activated receptor gamma (PPARγ) in complex coactivator 1-α (PGC-1α) interaction aromatase (encoded by CYP19A1). Use non-steroidal anti-inflammatory drugs (NSAID) may also affect circulating levels modifying PPARγ activity.In present study we assessed whether genetic variation...
Randomized clinical studies have shown a reduction in cardiovascular outcomes with glucagon-like peptide 1 receptor agonist (GLP-1RA) treatment the hypothesized mechanisms being an underlying effect on atherosclerosis. Here, we aimed to assess pharmacological effects of semaglutide atheroprone murine model that recapitulates central related vascular smooth muscle cell (VSMC) phenotypic switching and endothelial dysfunction known operate within atherosclerotic plaque.In study A, employed...
<b><i>Introduction:</i></b> Several mouse models with diverse disease etiologies are used in preclinical research for chronic kidney (CKD). Here, we performed a head-to-head comparison of renal transcriptome signatures standard CKD to assess shared and distinct molecular changes three commonly employed drug discovery. <b><i>Methods:</i></b> All experiments were conducted on male C57BL/6J mice. Mice underwent sham, unilateral ureter obstruction...
Abstract Background and Aims A range of mouse models are available in preclinical chronic kidney disease (CKD) research but differ their etiology pathological hallmarks. To enable better selection the CKD model optimal for drug discovery studies, we characterized transcriptome signature three well-established induced by unilateral ureter obstruction (UUO), ischemic reperfusion injury (uIRI) adenine-supplemented diet feeding (ADI). Method Male C57BL/6JRj mice were used all studies. UUO or...