A5008436018- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Soft tissue tumor case studies
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Renal and related cancers
- Cancer Research and Treatments
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Occupational and environmental lung diseases
- Biochemical Acid Research Studies
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
Fondazione IRCCS Istituto Nazionale dei Tumori
2014-2020
University of Milan
2011
BACKGROUND AND PURPOSE Iron aggravates the cardiotoxicity of doxorubicin, a widely used anticancer anthracycline, and iron chelator dexrazoxane is only agent protecting against doxorubicin cardiotoxicity; however, mechanisms underlying role in doxorubicin‐mediated protective remain to be established. As required for degradation hypoxia‐inducible factors (HIF), which control expression antiapoptotic genes, we tested hypothesis that dexrazoxane‐dependent HIF activation may mediate...
Malignant peritoneal mesothelioma (MpM), arising in the setting of local inflammation, is a rare aggressive tumour with poor prognosis and limited therapeutic options. The three major MpM histological variants, epithelioid (E-MpMs), biphasic, sarcomatoid MpMs (S-MpMs), are characterised by an increased aggressiveness enhanced levels EZH2 expression. To investigate immune contexture along spectrum histotypes, extended situ analysis was performed on series 14 cases. Tumour-infiltrating cells...
Indirect evidence suggesting the immunosensitivity/immunogenicity of neuroblastoma is accumulating. The aims this study were to investigate immune landscape and evaluate in vivo immunogenicity NY-ESO-1 tumor antigen advanced patients. infiltrating cells NY-ESO-1+ tumors from three HLA*A201 patients with metastatic who relapsed after conventional treatments evaluated by immunohistochemistry. vaccinated HLA-A*0201-restricted peptide NY-ESO-1157-165(V). was emulsified Montanide ISA51 given...
Sunitinib improves the outcomes of patients with solitary fibrous tumours (SFTs). The aim this study was to investigate and contextualise sunitinib-induced morpho-functional changes in order gain insights into drug's mechanism action.To end, four surgical specimens obtained from two sunitinib-responsive malignant SFT, one primary cell culture fresh tumoral tissue its stabilised line, were studied by means immunohistochemistry, bright field situ hybridisation, immunofluorescence/confocal...
e22006 Background: PNTs, a family of tumors arising in the embryonal remnants sympathetic nervous system, account for 7-10% all children. NMYC status, stage, and age are most important prognostic factors. The association patient prognosis could be influenced by maturity immune system. aims this study were to describe contexture PNTs investigate its relationships with tumor stage. Methods: A cohort 45 consecutive children PNT diagnosed treated at single centre (2008-2014) available primary...
e14726 Background: CD205 is a type I transmembrane surface protein belonging to the mannose receptor family with propensity for antigen uptake/internalization. expressed in different cancer histotypes and seems have role migration invasion. For these features an ideal candidate be exploited as ADC target. MEN1309/OBT076 (herein MEN1309) humanized IgG1 antibody against CD205, conjugated through cleavable linker DM4. It has shown impressive anti-tumor activity when tested high/low expressing...