A5052606115- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Amoebic Infections and Treatments
- Peroxisome Proliferator-Activated Receptors
- Calpain Protease Function and Regulation
- Pharmacogenetics and Drug Metabolism
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Forensic and Genetic Research
- Cytokine Signaling Pathways and Interactions
- Parasitic Infections and Diagnostics
- Paraoxonase enzyme and polymorphisms
- Genetic diversity and population structure
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Regulation of Appetite and Obesity
- Lipid metabolism and disorders
- T-cell and B-cell Immunology
- Genetic Associations and Epidemiology
- Gestational Diabetes Research and Management
- Drug-Induced Hepatotoxicity and Protection
- Epigenetics and DNA Methylation
- Atherosclerosis and Cardiovascular Diseases
- Meat and Animal Product Quality
- Pancreatic and Hepatic Oncology Research
Universidad de Guadalajara
2015-2024
Mexican Social Security Institute
1995-2016
Universidad de Occidente
2013
Abstract The genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis 716 newly genotyped individuals from 60 the 68 recognized ethnic groups in Mexico. We show that structure these is geography, our reconstructions suggest decline population size all tested last 15–30 generations. find evidence Aridoamerican Mesoamerican diverged roughly 4–9.9 ka, around time when sedentary farming...
The association between some Tumor necrosis factor-alpha (TNF- α ) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. aim of this study was to investigate the −308G/A −238G/A located region TNF- gene T2DM Mexican mestizo patients. Nine hundred four individuals (259 patients with 645 controls) were genotyped for by PCR—RFLP. We found that −238A allele increased risk developing (OR = 1.57, 95% CI:...
The association between some Tumor necrosis factor-alpha (TNF-α) promoter polymorphisms and Type 2 diabetes mellitus (T2DM) remains controversial. Ethnic differences may play a role in these conflicting results. aim of this study was to investigate the -308G/A -238G/A located region TNF-α gene T2DM Mexican mestizo patients. Nine hundred four individuals (259 patients with 645~controls) were genotyped for by PCR--RFLP. We found that -238A allele increased risk developing (OR=1.57, 95% CI:...
Background Gestational diabetes mellitus (GDM) is characterized by insulin resistance. It has been described that tumor necrosis factor α (TNF-α) plays a key role in the pathogenesis of resistance; moreover, increased levels this proinflammatory cytokine have reported women with GDM. Therefore, study was aimed to assess presence associations between -308G/A and -238G/A polymorphisms specific haplotypes TNF-α gene promoter region resistance Mexican Methods This included 51 GDM 44 pregnant...
Gestational diabetes mellitus (GDM) is a metabolically complex disease with major genetic determinants. GDM has been associated insulin resistance and dysfunction of pancreatic beta cells, so the candidate genes are those that encode proteins modulating function secretion insulin, such as for calpain 10 (CAPN10). This study aimed to assess whether single nucleotide polymorphism (SNP)-43, SNP-44, SNP-63, indel-19 variant, specific haplotypes CAPN10 gene were gestational mellitus. We studied...
The study's objective was to assess the association between PRSS1 R122H and N29I SPINK1 N34S mutations acute pancreatitis (AP) recurrent in Mexican pediatric patients.The were detected using polymerase chain reaction-restriction fragment length polymorphism, mutation allele-specific reaction 92 patients (58 AP 34 patients) 144 controls.We found 1 mutated allele 4 (4.3%) of none controls. All bearing had AP, with a frequency 6.8% (4/58). Three (5.2%) 58 heterozygous for mutation, (1.7%)...
To determine whether the well-known genetic structure of Mexican population observed with other multiallelic markers can be detected by analyzing functional polymorphisms cytokine and inflammatory-response-related genes.A total 834 Mestizo individuals from five cities 92 Lacandonians - an Amerindian group southeastern Mexico were genotyped for 14 in CRP, IL10, IL6, TGFB1, TNFA, LTA, ICAM1 IFNG, IL1RN genes. Allele haplotype frequencies used analysis using F-statistics pairwise distances...
Polymorphisms in the CYP2C9 and CYP2C19 genes confer potential risk for specific adverse drug reactions therapeutic effect failure. Their frequencies differ among ethnic groups. This study was aimed to describe distribution of alleles haplotypes four Mestizo populations from Western Mexico their comparison with reported data other groups.The CYP2C (CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3) were genotyped using polymerase chain reaction-restriction fragment length polymorphisms analyses DNA...
Polycystic ovary syndrome is a complex and heterogeneous disease leading to reproductive, as well metabolic problems. It has been suggested that there may be genetic predisposition in the aetiology of polycystic syndrome. The identification calpain 10 gene (CAPN10) first candidate for type 2 diabetes mellitus focused interest investigating their possible connection with This associated hyperinsulinaemia insulin resistance, two abnormalities mellitus. To investigate if association between...
Abstract The so‐called tumor necrosis factor ( TNF ) block includes the TNFA , lymphotoxin alpha and beta LTA LTB genes with single‐nucleotide polymorphisms SNP microsatellites an allele frequency that exhibits interpopulation variability. To date, no reports have included both SNPs at to study Mestizo or Amerindian populations from Mexico. In this study, samples of five Mexican (Durango, Guadalajara, Monterrey, Puebla, Tierra Blanca) four native‐Mexican (North Lacandonians, South...
El síndrome de ovario poliquístico es una enfermedad compleja y heterogénea que implica problemas reproductivos metabólicos. Se ha sugerido predisposición genética en la etiología este síndrome. La identificación del gen calpaína-10 (CAPN10) como el primer asociado a diabetes mellitus tipo 2 suscitó interés por investigar su posible relación con poliquístico, debido se asocia hiperinsulinemia resistencia insulina, anormalidades metabólicas relacionadas diabetes. Investigar si existe...
Polymorphisms in the LEP (G-2548A and A19G), LEPR (A326G, A668G G3057A) RETN (C-420G G+62A) genes were documented according to their association with alterations biochemical parameters such as glucose, insulin lipid profiles, along serum leptin resistin concentrations. The aim of study was establish any contribution G-2548A A19G polymorphisms gene, A326G, G3057A C-420G G+62A gene levels Mexican young adults. Clinical variables, levels, genotype profiles analysed 66 Seven LEP, genotyped using...
Few studies have addressed how selective pressures shaped the genetic structure of current Native American populations, and they mostly limited their inferences to admixed Latin populations. Here, we searched for local adaptation signals, based on integrated haplotype scores population branch statistics, in 325 Mexican Indigenous individuals with at least 99% ancestry from five previously defined geographical regions. Although each region exhibited its own profile, only PPARG AJAP1, both...
We undertook this study to determine the relationship among -174G>C and 598G>A polymorphisms in promoter region of interleukin-6, obesity, metabolic abnormalities subjects from central Mexico. Included were 150 who not first-degree relatives patients with diabetes 106 blood samples general population. All genotyped using polymerase chain reaction (PCR) restriction fragment-length polymorphism. Logistic regression analysis was used assess relationships haplotypes, abnormalities. Only 2...
The Lacandones are considered descendants of the Maya Civilization that found refuge in jungle during Spanish colonization. They were able to live absolute isolation until 1990 when an acculturation process began. This is a cross-sectional study included 46.7% total Lacandon population. Weight, height, overnight fasting plasma glucose, urea, creatinine, uric acid, hemoglobin, triglycerides and HDL-cholesterol levels determined. BMI age have positive correlation for subjects younger than 40...
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Understanding detecting risk factors are crucial for early diagnosis prevention strategies. Obesity, dyslipidemia, hypertension, insulin resistance, among others, have been described as modifiable factors. Among these, the triglycerides-to-HDL cholesterol (TG/HDL) ratio has marker resistance predictor cardiovascular disease. Our objective was to investigate association between TG/HDL various cardiometabolic...
Abstract The study of mitochondrial DNA is a valuable tool to delve into the demographic history human populations. Particularly in Americas, five widespread Native American specific lineages have been identified. Here we included complete mitogenome sequencing 572 Indigenous individuals belonging 60 populations spanning Mexican territory. Our results show great diversity matrilineages across country, revealing shared mtDNA haplogroups from distant regions. We identified all main clades,...