A5014680979- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Ocular Oncology and Treatments
- Head and Neck Surgical Oncology
- Ocular Diseases and Behçet’s Syndrome
- Lung Cancer Diagnosis and Treatment
- Ocular Infections and Treatments
- Drug-Induced Ocular Toxicity
- Thyroid Cancer Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Heat shock proteins research
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Brain Metastases and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Medical Imaging Techniques and Applications
- Bone Tumor Diagnosis and Treatments
Paul Scherrer Institute
2021-2024
ETH Zurich
2020-2023
Cincinnati Children's Hospital Medical Center
2020
Zentrum für Pathologie und Zytodiagnostik
1989
The purpose of this study is to report the oncological outcome, observed toxicities and normal tissue complication probability (NTCP) calculation for pencil beam scanning (PBS) PT delivered salivary gland tumour (SGT) patients.We retrospectively reviewed 26 SGT patients treated with PBSPT (median dose, 67.5 Gy(RBE)) between 2005 2020 at our institute. Toxicities were recorded according CTCAEv.4.1. Overall survival (OS), local control (LC), locoregional (LRC) distant (DC) estimated. For all...
Abstract Background Hypoxia is known to be prevalent in solid tumors such as non-small cell lung cancer (NSCLC) and reportedly correlates with poor prognostic clinical outcome. PET imaging can provide in-vivo hypoxia measurements support targeted radiotherapy treatment planning. We explore the potential of proton therapy performing patient-specific dose escalation compare it photon volumetric modulated arc (VMAT). Methods Dose has been calibrated patient specific tumor response ten stage...
Radiation-induced optic neuropathy (RION) is a rare side effect following radiation therapy involving the structures whose onset is, due to low amount of available data, challenging predict. We have analyzed multi-institutional cohort including 289 skull-base cancer patients treated with proton who all received >45 GyRBE apparatus. An overall incidence rate 4.2% (12) was observed, chordoma being at higher risk (5.8%) than chondrosarcoma (3.2%). Older age and arterial hypertension, tumor...
To investigate the impact of organ motion on hypoxia-guided proton therapy treatments for non-small cell lung cancer (NSCLC) patients.Hypoxia PET and 4D imaging data six NSCLC patients were used to simulate with different mitigation strategies including rescanning, breath-hold, respiratory gating tumour tracking. Motion-induced dose degradation was estimated treatment plans painting hypoxic sub-volumes at escalated levels. Tumour control probability (TCP) dosimetry indices assessed weigh...
Knowledge of biological responses to proton therapy (PT) in comparison X-ray remains its infancy. Identification PT specific molecular signals is an important opportunity for the discovery biomarkers and synergistic drugs advance clinical application. Since used treatment lymphoma, we report here transcriptomic lymphoma cell lines vs identify potential therapeutic targets.Two human (BL41) murine (J3D) origin were irradiated by PT. Differential transcriptome regulation was quantified RNA...
Objective. Investigating the aspects of proton beam delivery to track organ motion with pencil scanning therapy. Considering current systems as a reference, specify requirements for next-generation units aiming at real-time image-guided treatments.Approach. Proton treatments six non-small cell lung cancer (NSCLC) patients were simulated using repeated 4DCTs model respiratory variability. Energy corrections required this treatment site evaluated different approaches tumour tracking, focusing...
Purpose
4D computed tomography (4DCT) is the clinical standard to image organ motion in radiotherapy, although it limited imaging breathing variability. We propose a method transfer across longitudinal datasets include intra-patient variability and verify its performance lung cancer patients. 
Methods 
Five repeated control 4DCTs for 6 non-small cell patients were combined into multi-breath (m4DCT) by merging stages of deformable registration isolate respiratory motion. The...