A5012466891- Virus-based gene therapy research
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Modular Robots and Swarm Intelligence
- Regulation of Appetite and Obesity
- Bacteriophages and microbial interactions
- Adipose Tissue and Metabolism
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Metamaterials and Metasurfaces Applications
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cytomegalovirus and herpesvirus research
- Biochemical Analysis and Sensing Techniques
- Circular RNAs in diseases
- Opportunistic and Delay-Tolerant Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
China Medical University
2024
Salk Institute for Biological Studies
1999-2023
Shenzhen Blood Center
2003
ABSTRACT Lentivirus vectors can transduce dividing and nondividing cells. Using three-plasmid transient transfections, high-titer (>10 9 IU/ml) recombinant lentivirus pseudotyped with vesicular stomatitis virus G (VSV-G) protein be generated (T. Kafri et al., Nat. Genet. 17:314–317, 1997; H. Miyoshi Proc. Natl. Acad. Sci. USA 94:10319–10323, L. Naldini Science 272:263–267, 1996). The lentiviruses efficiently infect brain, liver, muscle, retinal tissue in vivo. Furthermore, the transduced...
Hypoxia-inducible factor-1α (HIF-1α) plays an essential role in cellular and systemic O 2 homeostasis by regulating the expression of genes important glycolysis, erythropoiesis, angiogenesis, catecholamine metabolism. It is also believed to be a key component response hypoxia ischemia under pathophysiological conditions, such as stroke. To clarify function HIF-1α brain, we exposed adult mice with late-stage brain deletion hypoxic injuries. Contrary expectations, brains from HIF-1 α-deficient...
Abstract Aging promotes numerous intracellular changes in T cells that impact their effector function. Our data show aging an increase the localization of STAT3 to mitochondria (mitoSTAT3), which mitochondrial dynamics and function T‐cell cytokine production. Mechanistically, mitoSTAT3 increased activity by increasing complex II. Limiting using a mitochondria‐targeted inhibitor, Mtcur‐1 lowered II activity, prevented age‐induced function, reduced Th17 inflammation. Exogenous expression...
Abstract VPS9D1‐AS1 functions as an oncogene in many cancers. However, its role and potential mechanism the progression of endometrial cancer (EC) are not fully understood. levels EC adjacent normal tissues were investigated using TCGA‐UCEC cohort 24 paired clinical samples. The roles miR‐187‐3p cell cycle, proliferation, apoptosis evaluated by loss‐ gain‐of‐function experiments. In addition, effect on tumor growth was further vivo. Rescue experiments performed to investigate involvement...
The transformation method that was originally used to tailor the physical fields into desired spatial patterns by designing material parameters is herein obtain necessary local dynamic when state distribution of a network system prescribed in space. This constitutes typical inverse problem controls complex its parameters. Thus, it difficult direct solution. coordinate provides method. feasibility this demonstrated and verified two examples (a communication field bender cloak) corresponding systems.