A5000895335- Ginger and Zingiberaceae research
- Alkaloids: synthesis and pharmacology
- Diet and metabolism studies
- Berberine and alkaloids research
- Electrochemical Analysis and Applications
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Organoselenium and organotellurium chemistry
- Biological and pharmacological studies of plants
- Fluoride Effects and Removal
- Treatment of Major Depression
- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Curcumin's Biomedical Applications
- Anesthesia and Neurotoxicity Research
- Biochemical Analysis and Sensing Techniques
- Drug Transport and Resistance Mechanisms
- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Pancreatic function and diabetes
- Sulfur Compounds in Biology
- Chemotherapy-induced cardiotoxicity and mitigation
- Immunotoxicology and immune responses
- Medicinal Plants and Neuroprotection
- Diet, Metabolism, and Disease
University of Ibadan
2022-2025
Excessive fluoride exposure beyond the tolerable limit may adversely impacts brain functionality. Betaine (BET), a trimethyl glycine, possesses antioxidant, anti-inflammatory and anti-apoptotic functions, although underlying mechanisms of role BET on fluoride-induced neurotoxicity remain unelucidated. To assess mechanism involved in neuro-restorative behavioural, neurochemical, histological changes, we employed rat model sodium (NaF) exposure. Animals were treated with NaF (9 mg/kg) body...
Parkinson's disease (PD) is a chronic neurodegenerative that occurs progressively with time. Current PD treatments are symptomatic moderate effects on striatal dopamine release. Previously, the ethnomedicinal benefits of Zingiber officinale Roscoe have been demonstrated to possess broad range pharmacological benefits, but no single data its effect against nigrostriatal degeneration in model has reported. Proactive neuroprotective and pharmacotherapeutic approaches asymptomatic needed prevent...
Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) DEN-only (200 single dose i.p.). Also, two other rat pre-treated DPDS (3 or 5 mg/kg) for 15 days (day: 0–15),...
Introduction/Background: The overuse of food additives and preservatives has become a source concern globally due to the inherent risks associated with them. This study evaluated neurobehavioral performance, atherogenic risk, oxido-inflammatory response in mice fed normal high-fat diets supplemented combined sodium benzoate (SB) monosodium glutamate (MSG). Materials/Methods: Mice were divided into four groups (n=6) diet (ND), (HFD), ND+MSG+SB, HFD + MSG +SB, respectively, for 28 days....
Berberine (BER) is a potent antioxidant and anti-inflammatory compound with several health benefits. We investigated the impact of sub-chronic BER supplementation on male rat reproductive function from prepubescence to adulthood. Wistar pups (PND 21) were divided into five groups (n = 10 pups/group). The control animals received distilled water (2 mL/kg, p.o), treated different doses BER: 25, 50, 100, 200 mg/kg body weight, p.o) PND 28 68. Using biochemical, histomorphological, pathology...