A5102946423- Toxoplasma gondii Research Studies
- Lipid Membrane Structure and Behavior
- Clostridium difficile and Clostridium perfringens research
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Malaria Research and Control
- Toxin Mechanisms and Immunotoxins
Centre for Human Genetics
2018-2022
University of Oxford
2018-2022
Oxford Nanopore Technologies (United Kingdom)
2021
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.
Structures of Toxoplasma perforin-like protein facilitate understanding the protein’s role in infection and disease.
Perforin-like proteins (PLPs) play key roles in mechanisms associated with parasitic disease caused by the apicomplexan parasites Plasmodium and Toxoplasma. The T. gondii PLP1 (TgPLP1) mediates tachyzoite egress from cells, while five PLPs carry out various life cycle of parasite respect to molecular basis disease. Here we focus on vivax PLP2 (PvPLP1 PvPLP2) compared TgPLP1. Determination crystal structure membrane-binding APCβ domain PvPLP1 reveals notable differences TgPLP1, reflected its...
Abstract Perforin-like proteins (PLPs) play key roles in the mechanisms associated with parasitic disease caused by apicomplexans such as Plasmodium (malaria) and Toxoplasma . The T. gondii PLP1 (TgPLP1) mediates tachyzoite egress from cells, while five PLPs carry out various life cycle of parasite respect to molecular basis disease. Here we focus on vivax PLP2 (PvPLP1 PvPLP2) compared TgPLP1; PvPLP1 is important for invasion mammalian hosts establishment a chronic infection, PvPLP2 during...