A5003775594- Ginseng Biological Effects and Applications
- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
- Carbohydrate Chemistry and Synthesis
- Microbial Metabolic Engineering and Bioproduction
- Microbial Natural Products and Biosynthesis
- Medicinal Plant Pharmacodynamics Research
- Plant Molecular Biology Research
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2023
National Health and Family Planning Commission
2018-2020
Xinjiang Institute of Materia Medica
2019
Peking Union Medical College Hospital
2019
A green and sustainable approach is established by metabolic engineering for industrial production of bioactive dammarenediol-II glucosides.
Construction of engineered yeast for de novo synthesis unnatural ginsenoside 12β- O -Glc-PPD.
Glycosylation, which is catalyzed by UDP-glycosyltransferases (UGTs), an important biological modification for the structural and functional diversity of ginsenosides. In this study, promiscuous UGT109A1 from
Objective: Nonsmall-cell lung cancer (NSCLC) is an aggressive, highly chemoresistant disease. Taxol effective chemotherapeutic drug widely used for the treatment of NSCLC. However, clinical use limited due to occurrence adverse side effects under high therapeutic doses. Therefore, it desirable explore combination therapy reduce dose drugs and achieve excellent outcomes. A biosynthetic ginsenoside, 3-O-β-D-glucopyranosyl-dammar-24-ene-3β, 20S-diol (3β-O-Glc-DM, C3DM) obtained from microbial...