A5051284682- Innovations in Medical Education
- Migration, Aging, and Tourism Studies
- Global Health Workforce Issues
- Poverty, Education, and Child Welfare
- Aging and Gerontology Research
- Health disparities and outcomes
- Mesenchymal stem cell research
- Global Educational Reforms and Inequalities
- Monoclonal and Polyclonal Antibodies Research
- Telomeres, Telomerase, and Senescence
- Global Educational Policies and Reforms
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Primary Care and Health Outcomes
- Hematopoietic Stem Cell Transplantation
- Peace and Human Rights Education
- Surgical site infection prevention
- Climate Change Communication and Perception
- NF-κB Signaling Pathways
- interferon and immune responses
- Central Venous Catheters and Hemodialysis
- Natural Compounds in Disease Treatment
- Chromosomal and Genetic Variations
- Lung Cancer Treatments and Mutations
- Erythrocyte Function and Pathophysiology
James Cook University
2018-2024
Australian Institute of Tropical Health and Medicine
2018
Transgenomic (United States)
2017
Sidney & Lois Eskenazi Hospital
2008
Houston Methodist
2008
Indiana University Health
2008
Stanford University
1999-2006
University of Colorado Boulder
2002
Stanford Medicine
2001
Queen's Medical Centre
1996
Abstract Purpose: The mechanisms accounting for anticancer activity of AZD9291 (osimertinib or TAGRISSO), an approved third-generation EGFR inhibitor, in EGFR-mutant non–small cell lung cancer (NSCLC) cells and particularly the subsequent development acquired resistance are unclear thus focus this study. Experimental Design: AZD9219-resistant lines were established by exposing sensitive to AZD9291. Protein alterations detected with Western blotting. Apoptosis was measured annexin V/flow...
The essential Cdc13 protein in the yeast Saccharomyces cerevisiae is a single-stranded telomeric DNA binding required for chromosome end protection and telomere replication. Here we report solution structure of domain complex with DNA. reveals use single OB (oligonucleotide/oligosaccharide binding) fold augmented by an unusually large loop recognition. This structurally similar to folds found ciliated protozoan end-binding protein, although no sequence similarity apparent between them....
Triptolide (PG490), a diterpene triepoxide, is potent immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii. We have previously shown that triptolide blocks NF-kappaB activation and sensitizes tumor necrosis factor (TNF-alpha)-resistant cell lines to TNF-alpha-induced apoptosis. show here enhances chemotherapy-induced In triptolide-treated cells, expression of p53 increased but transcriptional function was inhibited, we observed down-regulation p21(waf1/cip1),...
Interferon gamma (IFN‐γ) induces apoptosis in many tumor cell lines and sensitizes cells to by necrosis factor family members. IFN‐γ the expression of early response genes such as interferon regulatory factor‐1 (IRF‐1) activation signal transducer activator transcription (STAT) proteins. We found that ME180 became resistant IFN‐γ‐induced death after 4–5 passages culture. These were characterized a loss STAT1 inducible IRF‐1 expression. describe for first time emergence STAT1‐deficient line.
(1) Background: Studies have shown that older people prefer to continue living in their own home and community as they age; however this is dependent upon available services social support. In Australia about two thirds of will age at home. The Australian Government provides care packages support ageing place yet rural areas not all are available. lack employment opportunities often results family residing a distance reducing This study aims evaluate informal its influence on amongst three...
Abstract Objective Globally, most doctors train and work in metropolitan areas but a key strategy for developing the rural health workforce is expanding training. The aim of this study was to describe scope quality learning along with skill acquisition GP trainees based regional, rural, remote settings. Setting Regional, settings Queensland Australia excluding Brisbane. Participants Thirty‐seven general practice who had undertaken their first community placement were recruited from within...
Abstract Background An equitable supply and distribution of medical practitioners for all the population is an important issue, especially in Australia where 28% live rural remote areas. Research identified that training rural/remote locations a predictor uptake practice, but must provide comparable learning clinical experiences, irrespective location. Evidence shows GPs areas are more likely to be engaged complex care. However, quality GP registrar education has not been systematically...
We have assessed hematopoietic progenitor cell preparations (including CD34-positive stem cells) obtained from human fetal liver at 6–17 weeks of gestational age for total numbers, viability and the ability to tolerate (frozen) storage. Hematopoietic 16- 17-week range had highest count greatest proportion cells. However, these were insufficiently robust withstand freeze/thaw protocol required. Cells 13- 15-week showed optimal post-thaw it is suggested that are most applicable in utero...
Patients with congenital heart defects are a unique population generally immature immune systems. Fragility in the postoperative period may contribute to surgical site infections (SSIs), life threatening complication for this population. The need antimicrobial prophylaxis these patients is standard of care that indisputable. When choosing an regimen prophylaxis, consideration should be given balancing prevention nosocomial infections, avoiding emergence bacterial resistance, and minimizing...
Background: Although clinician-researchers are an essential part of the health workforce, number clinical researchers is declining. Student participation in research during medical school has been shown to promote a future interest research. Therefore, research, it important evaluate educational pathways and impediments students undertaking at school.Methods: Semi-structured interviews were conducted identify challenges, benefits enablers for who or have graduated from embedded honours...
Abstract Objective Ageing is a time of change that might involve financial, health and social losses. To maintain well‐being, older people need to engage range resources cope with these However, national policies mainly focus on financial resources. This study used Folkman Lazarus’s transactional theory identify coping methods engaged by adults living in three rural communities. Design A qualitative research design was undertaken using an ethnographic case approach. Setting Three communities...
Community-acquired pneumonia is a considerable cause of morbidity and mortality contributes significantly to healthcare resource utilization worldwide. Clinical practice guidelines developed by international societies have been published improve the diagnosis, management, prevention community-acquired pneumonia. This review current aimed at choosing an appropriate therapeutic approach including local considerations, site care decisions, diagnostic testing, antimicrobial therapy, prevention.
2518 Background: Cytokine induced killer cells (CIKs) are ex-vivo activated and expanded CD8+ natural T that have been shown to cytotoxic activity against cancers in randomized clinical trials. This preclinical study demonstrates the enhanced effect of CIK killing primary ovarian carcinoma using bispecific antibodies (BSAbs) potential translating our findings a trial. Methods: Primary cancer autologous CIKs were collected cultured under IRB approval. Cytotoxicity enhancing BSAbs CA125...
<h3>Purpose of Study</h3> Cytokine-induced killer cells (CIKs) are ex vivo activated and expanded CD8<sup>+</sup> natural T that have been shown to cytotoxic activity against cancers in randomized clinical trials. We determined the CIK endometrioid serous papillary (UPSC) uterine cancer cell lines evaluated ability trastuzumab Her2xCD3 bispecific antibodies enhance CIK-mediated cytotoxicity Her2/neu-expressing cells. <h3>Methods</h3> CIKs were generated by activating donor with...
Angiotensin affects the growth of many cell types and there have been suggestions that it could influence cells which respond to erythropoietin. During first trimester, human fetal haematopoietic are exquisitely responsive erythropoietin we assessed potential for angiotensin also these in a standard culture system. The data obtained from studies indicate does not haematopoiesis over range concentrations.