A5064989058- Surgical Simulation and Training
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Pleural and Pulmonary Diseases
- Simulation-Based Education in Healthcare
- Lung Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Tissue Engineering and Regenerative Medicine
- Anatomy and Medical Technology
- Congenital Heart Disease Studies
- Augmented Reality Applications
- Acute Myocardial Infarction Research
- Electrospun Nanofibers in Biomedical Applications
- Occupational and environmental lung diseases
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Hemodynamic Monitoring and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Virtual Reality Applications and Impacts
- Aortic aneurysm repair treatments
Leiden University Medical Center
2007-2025
Erasmus MC
2018-2024
Erasmus University Rotterdam
2018-2024
Dialyse Centrum Groningen
2012
New York Proton Center
2012
Manitoba Health
2009
Loyola University Medical Center
2007
Abstract Epicardium and epicardium‐derived cells have been shown to be necessary for myocardial differentiation. To elucidate the function of podoplanin in epicardial development differentiation, we analyzed knockout mouse embryos between embryonic day (E) 9.5 E15.5 using immunohistochemical differentiation markers, morphometry, three‐dimensional reconstructions. Podoplanin null mice an increased lethality, possibly cardiac origin. Our study reveals impairment proepicardial organ, adhesion,...
There has been an increasing trend toward pulmonary segmentectomies to treat early-stage lung cancer, small intrapulmonary metastases, and localized benign pathology. A complete preoperative understanding of anatomy is essential for accurate surgical planning case selection. Identifying intersegmental divisions extremely difficult when performed on computed tomography. For the segmentectomies, virtual reality (VR) artificial intelligence could allow 3-dimensional visualization complex...
Serological responses to COVID-19 vaccination are diminished in recipients of solid organ transplants, especially lung transplant (LTR), probably as result immunosuppressive treatment. There is currently no marker immunosuppression that can be used predict the response. Here, we study whether torque tenovirus (TTV), a highly prevalent virus an indicator immunosuppression.The humoral response mRNA 1273 vaccine was assessed 103 LTR, who received between 4 and 237 months prior vaccination, by...
Abstract Recent advances in the study of cardiac development have shown relevance addition myocardium to primary myocardial heart tube. In wild‐type mouse embryos (E9.5–15.5), we studied at venous pole using immunohistochemistry and 3D reconstructions expression patterns MLC‐2a, Nkx2.5, podoplanin, a novel coelomic marker. Podoplanin‐positive epithelium was continuous with adjacent podoplanin‐ MLC‐2a‐positive that formed conspicuous band along left cardinal vein extending through base atrial...
Abstract Platelet‐derived growth factor receptor alpha ( Pdgfr α) identifies cardiac progenitor cells in the posterior part of second heart field. We aim to elucidate role α this region. Hearts α‐deficient mouse embryos (E9.5–E14.5) showed malformations consisting atrial and sinus venosus myocardium hypoplasia, including venous valves sinoatrial node. In vivo staining for Nkx2.5 increased myocardial expression mutants, confirmed by Western blot analysis. Due hypoplasia primary septum,...
Increased complexity in cardiac surgery over the last decades necessitates more precise preoperative planning to minimize operating time, limit risk of complications during and aim for best possible patient outcome. Novel, realistic, immersive techniques, such as three-dimensional (3D) virtual reality (VR) could potentially contribute phase. This study shows our initial experience on implementation VR technology a complementary research-based imaging tool cardiothoracic surgery. In addition,...
What are the new findings?► Due to COVID-19 pandemic, gathering restrictions have challenged organisation of physical multidisciplinary meetings, requiring innovative remote meeting methods, such as immersive virtual reality (VR)-based method presented in this article.► Immersive VR-based coronary revascularisation meetings were organised enable discussion between cardiac surgeons and cardiologists.How might it impact on healthcare future?► In near future, extended platforms could overcome...
Cardiac arrest after cardiac surgery commonly has a reversible cause, where emergency resternotomy is often required for treatment, as recommended by international guidelines. We have developed virtual reality (VR) simulation training of cardiopulmonary resuscitation (CPR) and procedures surgery, the Cardiopulmonary Resuscitation Virtual Reality Simulator (CPVR-sim). Two fictive clinical scenarios were used: one case pulseless electrical activity (PEA) combined PEA ventricular fibrillation....
External chest compressions are often ineffective for patients arresting after cardiac surgery, whom emergency resternotomy may be required. A single-blinded randomized controlled trial (RCT) was performed, with participants being to a virtual reality (VR) Cardiac Surgical Unit Advanced Life Support (CSU-ALS) simulator training arm or conventional classroom CSU-ALS arm. Twenty-eight cardiothoracic surgery (CTS) residents were included and subsequently assessed in moulage scenario groups of...
Abstract We investigated the role of podoplanin in development sinus venosus myocardium comprising sinoatrial node, dorsal atrial wall, and primary septum as well cardinal pulmonary veins. analyzed wild‐type knockout mouse embryos between embryonic day 9.5–15.5 using immunohistochemical marker podoplanin; sinoatrial‐node HCN4; myocardial markers MLC‐2a, Nkx2.5, Cx43; coelomic WT‐1; epithelial‐to‐mesenchymal transformation E‐cadherin RhoA. Three‐dimensional reconstructions were made...
Mice lacking the zinc finger transcription factor specificity protein 3 (Sp3) die prenatally in C57BL/6 background. To elucidate cause of mortality we analyzed potential role Sp3 embryonic heart development. null hearts display defective looping at day 10.5 (E10.5), and E14.5 mutants have developed a range severe cardiac malformations. In an attempt to position developmental hierarchy, expression patterns >15 marker genes hearts. Expression ankyrin repeat (Carp) was downregulated prematurely...
Extended reality (XR) modalities in health care are quickly evolving. There is a lack of systematically described developmental process and the "how to" execute business-case guidance. This article formulates systematic approach on technical steps generation to guide iterative development an XR tool. An international expert group was established several available frameworks related entrepreneurship were used generate recommendations. Our ongoing experience with life cycle tool for...
Abstract The inhibitor of differentiation Id2 is expressed in mesoderm the second heart field, which contributes myocardial and mesenchymal cells to primary tube. role cardiac development insufficiently known. Heart was studied sequential developmental stages wildtype knockout mouse embryos. Expression patterns Id2, MLC‐2a, Nkx2.5, HCN4, WT‐1 were analyzed. progenitor at inflow outflow tract, endocardial epicardial lineage, neural crest cells. embryos show severe defects including abnormal...
We conducted a prospective study to assess the face and content validity of new virtual reality (VR) extracorporeal circulation simulator (ECC) developed for perfusionists facilitate training practice. evaluated opinions students staff members about feasibility simulation. The 2 groups consisted experts (qualified perfusionists) novices (trainee perfusionists).Perfusionists (n = 12 n 11 trainees) received instructions on how use VR then proceeded perform start cardiopulmonary bypass in...
Abstract BACKGROUND Sex does have an effect on disease perception and outcomes after cardiac surgery. OBJECTIVES The aim of this study was to quantify the differences in cardiovascular risk profiles within age-matched cohort assess long-term survival males females who underwent surgical aortic valve replacement (SAVR) with or without concomitant coronary artery bypass METHODS All-comers patients SAVR surgery were included. Characteristics, clinical features up 30 years compared between...
Electrical Activity and RhoA in the Embryo . Introduction: Myocardium at venous pole (sinus venosus) of heart has gained clinical interest as arrhythmias can be initiated from this area. During development, sinus venosus myocardium is incorporated to primary tube expresses different markers than myocardium. We aimed elucidate development myocardium, including sinoatrial node (SAN), by studying expression patterns relation other markers, electrical activation developing Methods Results:...