A5049926526- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Biomarkers in Disease Mechanisms
- Gut microbiota and health
- Endometriosis Research and Treatment
- Autoimmune and Inflammatory Disorders
- Extracellular vesicles in disease
- Inflammation biomarkers and pathways
- Hidradenitis Suppurativa and Treatments
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Stoma care and complications
Institut d'Investigació Sanitària Pere Virgili
2021-2025
Universitat Rovira i Virgili
2022-2024
Instituto de Salud Carlos III
2022
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2022
Crohn's disease [CD] is associated with complex microbe-host interactions, involving changes in microbial communities, and gut barrier defects, leading to the translocation of microorganisms surrounding adipose tissue [AT]. We evaluated presence beige AT depots CD questioned whether succinate and/or bacterial promotes white-to-beige transition adipocytes.Visceral [VAT] subcutaneous [SAT] biopsies, serum plasma were obtained from patients active [n = 21] or inactive 12] CD, healthy controls...
Abstract Background The hyperplasia of the mesenteric adipose tissue in Crohn’s disease, known as creeping fat, is associated with transmural lesions and translocation microbial antigens. In a rat model TNBS-induced colitis, 50% animals presented hyperplasia. Macroscopic evaluations showed that these had more advanced progression colonoscopy could predict presence fat two days before euthanasia (L Clua et al, ECCO, 2024). Methods Colitis was induced using TNBS (n=10; half female), being...
Abstract Background Crohn's Disease (CD) is a chronic autoimmune disorder of the gastrointestinal tract, marked by persistent pro-inflammatory environment. A hallmark feature formation creeping fat (CrF), an immunologically active adipose tissue that exacerbates inflammation and disease progression (1). Anti-tumor necrosis factor (TNF) therapies, like Infliximab, are widely used to reduce intestinal in CD. Notably, we showed Infliximab not only alleviates but also affects behavior CrF (2)....
Abstract Background Circulating succinate, a metabolite produced by both the intestinal microbiota and host, is elevated in several diseases characterized chronic inflammation (1). In Crohn's disease (CD), an association has been observed between increased succinate levels lumen, activity, dysbiosis (2,3). The objective to evaluate circulating as biomarker of activity patients with active inactive CD relate these fecal microbiota, well demographic, clinical, treatment variables. Methods This...
Abstract Background Crohn’s disease (CD) is a chronic, idiopathic inflammatory bowel characterised by discontinuous lesions and transmural inflammation that can affect the entire gastrointestinal tract. Despite recent therapeutic advancements, around 50% of patients with CD require at least one surgical intervention within ten years diagnosis, 80% these developing new following surgery.1 Emerging evidence highlights efficacy mesenchymal stem cells (MSCs) predominantly attributed to...
Abstract Background and Aims Crohn’s disease [CD] is characterised by the expansion of mesenteric adipose tissue [MAT], named creeping fat [CF], which seems to be directly related activity. Adipose-stem cells [ASCs] isolated from CF patients with CD are extremely pro-inflammatory, persists during remission. We hypothesised that dysfunctional ASCs in accumulate epigenetic modifications triggered inflammatory environment, could serve as molecular markers. Methods Genome-wide DNA methylome...
Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn's disease (CD), yet one-third fail benefit from this treatment. Patients CD develop a characteristic wrapping visceral adipose tissue (VAT) in inflamed intestinal area, termed creeping fat, and it is known that expansion influences efficacy anti-TNF drugs. We questioned whether therapies impact fat CD, which might affect outcome disease. Adipose biopsies were obtained cohort 14 received drugs...
Patients with Crohn’s disease (CD) who smoke are known to have a worse prognosis than never-smokers and higher risk for post-surgical recurrence, whereas patients quit smoking after surgery significantly lower post-operative recurrence. The hypothesis was that induces epigenetic changes impair the capacity of adipose stem cells (ASCs) suppress immune system. It also questioned whether this impairment remains in ex-smokers CD. ASCs were isolated from non-smokers, smokers CD their interactions...
Abstract Background Crohn's disease (CD) is characterized by the expansion of mesenteric fat, known as creeping fat (CrF), to inflamed segments intestine. Our group observed that CrF showed a conversion beige tissue, phenomenon "Browning", an elevated gene expression thermogenin (UCP-1), characteristic browning1. A recent study also when browning was induced in mice TNBS colitis model, hypertrophy improved and inflammation adipose tissue reduced2. The aim this assess whether administration...
Abstract Background Crohn’s disease (CD) is characterised by expansion of mesenteric adipose tissue, called creeping fat, which seems to be directly related activity. Adipose stem cells (ASCs) isolated from the fat CD patients exhibit dysfunction, featuring impaired adipogenesis and an intensely pro-inflammatory phenotype. This study aims explore transcriptome ASCs active inactive subjects in comparison with healthy subjects, seeking key markers this dysregulation. Methods Patients were...
Abstract Background Crohn’s disease (CD) is characterized by persistent inflammation and ulcerations at the small or large bowel, provoking chronic low-grade systemic inflammation. Adipose tissue (AT) believed to play an active role in pathogenesis of CD, as expansion mesenteric fat attached inflamed segments intestine, also known “creeping fat,” a hallmark that seems be directly related activity. We demonstrated adipose-stem cells (ASC) isolated from creeping CD patients showed...
Abstract Background Crohn’s disease (CD) is characterized by the expansion of mesenteric fat attached to inflamed segments intestine, also known as “creeping fat” which seems be directly related activity. Our group revealed that adipose-stem cells (hASCs) isolated from creeping CD subjects are dysfunctional (showing a high inflammatory profile, invasive and phagocytic capacities, worse immunosuppressive properties); this dysfunction maintained even in hASCs remission disease.1 Methods 1)...
Abstract Background Crohn’s disease (CD) is characterized by severe transmural inflammation with subsequent destruction of the intestinal barrier. Bacterial infiltration across this leaky gut facilitates access to mesenteric fat and development a inflammatory reaction in surrounding adipose tissue named creeping (CF). Dysbiosis CD patients has been associated an increase succinate-producing bacteria decrease succinate-consuming bacteria. In fact, elevated succinate levels have found...