A5101672225- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Circadian rhythm and melatonin
- Osteoarthritis Treatment and Mechanisms
- Congenital heart defects research
- Diabetes Treatment and Management
- Hypothalamic control of reproductive hormones
- Sexual Differentiation and Disorders
- Medical Research and Treatments
- Nausea and vomiting management
- Genetic factors in colorectal cancer
- Alkaline Phosphatase Research Studies
- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Genetics and Neurodevelopmental Disorders
- Olfactory and Sensory Function Studies
- Music Therapy and Health
- Cardiovascular Disease and Adiposity
- Plant-based Medicinal Research
- Pathogenesis and Treatment of Hiccups
- Phenothiazines and Benzothiazines Synthesis and Activities
Zhengzhou Children's Hospital
2015-2022
Zhengzhou University
2019-2022
Army Medical University
2017-2018
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2007-2012
First Affiliated Hospital of Henan University
2010
Home quarantine due to the global coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on children. Lifestyle changes have led an increase in precocious puberty (PP) among girls, and underlying risk factors for this remain unclear. Thus, we aimed assess influence of environmental, genetic, nutritional, other lifestyle PP girls. We evaluated incidence new-onset girls during home COVID-19 analyzed potential factors. This was retrospective questionnaire medical record-based...
To study the clinical features, genetic etiology, and correlation between phenotype genotype of neonatal diabetes mellitus (NDM) in Chinese patients.We reviewed medical records 25 NDM patients along with their follow-up details. Molecular analysis was performed. We compared HbA1c levels PNDM group infantile-onset T1DM patients.Of patients, 18 (72.0%) were 7 (28.0%) TNDM. Among cases, 6 (33.3%) had known KATP channel mutations (KATP-PNDM). There six non-KATP mutations, five novel including...
Compound K is one of the active metabolites Panaxnotoginseng saponins, which could attenuate formation atherosclerosis in mice modelsvia activating LXRα. We synthesized and evaluated a series ginsenoside compound derivatives modified with short chain fatty acids. All structures this class derivative exhibited comparable or better biological activity than K. Especially structure 1 best potency (cholesteryl ester content: 41.51%; expression ABCA1 mRNA: 319%) low cytotoxicity.
Congenital hyperinsulinism (CHI) is the most common cause of severe, persistent hypoglycemia in neonates and infants. If patient does not respond to medical treatment currently available subtotal pancreatectomy, but some patients still experience severe after surgery. Sirolimus, a mammalian target rapamycin inhibitor has recently been reported be effective insulinoma CHI patients. Here we report with who had prolonged pancreatectomy. The heterozygous mutation ABCC8 was unresponsive an...
To identify pathogenic mutation in a pedigree affected with brachydactyly and obesity.Peripheral blood sample was collected for extraction of genomic DNA. Exons capture combined next generation sequencing (NGS) carried out to potential mutation. Sanger used verify the results.NGS has identified novel heterozygous missense (c.125A>C, p.Gln42Pro) exon 1 PTHLH gene. The result verified by sequencing. mutations derived from his mother. His uncle sister have also same mutation.A gene been type E2 obesity.
The purpose of this study was to determine the frequency maturity-onset diabetes young (MODY) in two selected cohorts Chinese children with and clinically suspected MODY, using next-generation sequencing (NGS). Ninety-three who met comprehensive criteria MODY were enrolled cohorts. A custom NGS panel or a whole exon group used for sequencing. We identified 55/93 (59.1%) pathogenic likely variants. Forty-two (76.3%) confirmed have GCK (MODY2) mutation. Additionally, five had HNF1A (MODY3),...
To explore the genetic basis for a girl featuring bone and tooth mineralization disorder, premature deciduous teeth, rickets short stature.Genomic DNA was extracted subjected to high-throughput whole exome sequencing. Suspected variants were confirmed by Sanger Impact of potential analyzed with bioinformatic software.The child found carry compound heterozygous missense ALPL gene, including c.1130C>T (p.A377V), known pathogenic mutation inherited from her father, c.1300G>A (p.V434M) mother,...
Clinical characteristics were analyzed in a child with very long chain acyl-CoA dehydrogenase deficiency(VLCADD). The gene analysis was performed 20 exon all coding regions and 10 bp shear zone the dehydrogenase(VLCAD)gene of case his family members by direct sequencing PCR-DNA from peripheral blood. results showed that patient presented acute onset, clinical manifestations repeated vomiting, poor spirit, abnormal liver function, increased myocardial enzyme kinase. At age one year old, this...
Objective According to the change of AAI in fentanil-propofol intravenous anesthesia fiberoptic intestine endoscopy diagnosis and treatment fiber, compared monitoring with routine monitoring, study was reduce dosage anesthetics effectively its side effects, based on appropriaste control depth anesthesia. Methods Sixty patients were randomly divided into group A (observe group) B (contrast group), 30 per group. Group A, besides SBP, DBP, HR SpO2, value monitored continuously by A-liner...
Objective To explore effect of nicotine on the inflammatory response chondrocytes induced by interleukin-1β (IL-1β) and nuclear factor kappa B (NF-κB) signal pathway. Methods Rat primary were isolated collagenase digestion. Effect 10-8, 10-7, 10-6, 10-5 mol/L viability was detected methyl thiazol tetrazolium (MTT). Chondrocytes divided into 5 groups, normal group (without any drug stimulation), model (10 μmol/L IL-1β), low, middle high dose (10-8, 10-6 mol/L+ 10 IL-1β). The MTT assay....