A5067174344- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Meningioma and schwannoma management
- HER2/EGFR in Cancer Research
- Genomics and Chromatin Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Protein Tyrosine Phosphatases
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Breast Cancer Treatment Studies
Centre Jean Perrin
2016-2025
Inserm
2011-2025
Université Clermont Auvergne
2014-2024
Imagerie Moléculaire et Stratégies Théranostiques
2016-2023
Laboratoire Jean Perrin
2019
Target (United States)
2015
Université de Strasbourg
2011
Université de Bordeaux
2011
Centre National de la Recherche Scientifique
2010-2011
Genetique Reproduction and Developpement
2010
Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence situ hybridisation. Amplification events were detected only glioblastomas (15 out of 36 cases), the most malignant tumours, significantly associated with decreased patient
Radiation therapy plays a central role in the treatment of glioblastoma, but it is not curative due to high tumor radioresistance. Phosphatidyl-inositol 3-kinase/protein kinase B (Akt) and Janus (JAK)/signal transducer activator transcription 3 (STAT3) pathways serve block apoptosis process, keeping cells alive very toxic environments such as chemotherapy or ionizing radiation. In present study, from panel 8 human malignant glioma cell lines, investigations on relationship between intrinsic...
In the present study, we have evaluated efficacy and toxicity of repeated brain metastases (BM) stereotactic radiosurgery (SRS2) following local failure a prior radiosurgical procedure (SRS1). Between December 1996 August 2015, 30 patients with 36 BM underwent SRS2 median dose 18Gy. All were located outside critical structures. Following SRS2, control at 6 months one year respectively 82.9% (IC 95%: 67.6–91.9) 67.8% 51–81). On multivariate analysis, planning target volume (PTV) < 3cc (HR:...
Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair.Dbait (which stands for strand bait) molecules mimic DSBs and trap repair proteins, thereby inhibiting of damage induced by radiation therapy (RT).First, the cytotoxic efficacy Dbait in combination with RT was evaluated vitro SK28 501mel human melanoma cell lines.Though extent RT-induced not increased Dbait, it persisted longer revealing a defect.Dbait enhanced independently doses.We...
Glioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting potential therapeutic target, relevance of WNT6, an activator this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated GBM. silenced or overexpressed GBM cells assess functional effects vitro vivo. Phospho-kinase arrays TCF/LEF...
In cancer cells, aberrant DNA methylation is commonly associated with transcriptional alterations, including silencing of tumor suppressor genes. However, multiple epigenetic mechanisms, polycomb repressive marks, contribute to gene deregulation in cancer. To dissect the relative contribution methylation–dependent and –independent mechanisms alterations at CpG island/promoter-associated genes cancer, we studied 70 samples adult glioma, a widespread type brain tumor, classified according...
Abstract The aim of this study was to test in vitro the efficacy TAC, an original G-quadruplex ligand, as a potential radiosensitizing agent for glioblastoma multiforme (GBM). Two human radioresistant telomerase-positive GBM cell lines (SF763 and SF767) were analyzed, with without TAC treatment, telomere length, proliferation, apoptosis, cell-cycle distribution, gene expression, cytogenetic aberrations, clonogenic survival assay, 53BP1 immunofluorescence staining, γH2AX phosphorylation. We...
Abstract Telomeres are nucleoprotein structures at the end of chromosomes which stabilize and protect them from nucleotidic degradation end-to-end fusions. The G-rich telomeric single-stranded DNA overhang can adopt a four-stranded G-quadruplex structure (G4). Stabilization G4 by binding small molecule ligands enhances radiosensitivity tumor cells this combined treatment represents novel anticancer approach. We studied effect platinum-derived G4-ligand, Pt-ctpy, in association with radiation...
The optimization of the management for elderly glioblastoma patients is crucial given demographics aging in many countries. We report outcomes a "real-life" patient cohort (i.e. unselected) comprising consecutive aged 70 years or more, treated with different radiotherapy +/− temozolomide regimens. From 2003 to 2016, 104 ≥ age, consecutively by glioblastoma, were included this study. All diagnosed IDH-wild type according pathological criteria. Our comprised 51 female (49%) and 53 male. median...
In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, D. This highly conserved family belongs to homeobox class of that encode transcription factors required for normal development. Therefore, gene deregulation might contribute development many cancer types. Here, we study adult glioma, a common type primary brain tumor. We performed extensive molecular analysis tumor samples, classified according their...
Besides the consequences of retrotransposition, long interspersed element 1 (L1) retrotransposons can affect host genome through their antisense promoter. In addition to sense promoter, evolutionarily recent L1 retrotransposons, which are present in several thousand copies, also possess an anti-sense promoter that produce chimeric transcripts (LCT) composed 5' UTR followed by adjacent genomic sequence. The full extent LCT expression occurs a given tissue and whether disruption defense...
Radiotherapy is an essential component of glioma standard treatment. Glioblastomas (GBM), however, display important radioresistance leading to tumor recurrence. To improve patient prognosis, there a need radiosensitize GBM cells and circumvent the mechanisms resistance caused by interactions between their microenvironment. STAT3 has been identified as therapeutic target in because its involvement sustaining escape both treatment immune control. Here, we studied role activation on tyrosine...
Malignant gliomas are the most common primary brain tumors. Grade III and IV harboring wild-type IDH1/2 aggressive. In addition to surgery radiotherapy, concomitant adjuvant chemotherapy with temozolomide (TMZ) significantly improves overall survival (OS). The methylation status of O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter is predictive TMZ response a prognostic marker cancer outcome. However, regions which correlates best in aggressive glioma whether value could be refined...