A5024202954- Telomeres, Telomerase, and Senescence
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Menopause: Health Impacts and Treatments
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Cellular Mechanics and Interactions
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Protein Tyrosine Phosphatases
- S100 Proteins and Annexins
- Gene expression and cancer classification
- Machine Learning in Bioinformatics
- Protein Kinase Regulation and GTPase Signaling
- Advanced Biosensing Techniques and Applications
- Antioxidant Activity and Oxidative Stress
- Cancer Genomics and Diagnostics
- Sirtuins and Resveratrol in Medicine
- Redox biology and oxidative stress
- Glycosylation and Glycoproteins Research
- Alzheimer's disease research and treatments
Universiti of Malaysia Sabah
2019-2025
Ingham Institute
2013-2022
Western Sydney University
2013-2022
Liverpool Hospital
2022
The cell death pathway, including apoptosis, autophagy, and necroptosis, plays an essential role in hepatocellular carcinoma (HCC) progression outcome. However, the integration of three pathways into a prognostic signature has not yet been reported HCC. This study aimed to investigate association among death-related genes (CDRGs), prognosis, immune microenvironment, checkpoint. RNA expression profiles corresponding clinical data HCC were retrieved from Cancer Genome Atlas (TCGA), Gene...
Aims Breast cancer is a hormonally driven disease. Cellular senescence an age‐related irreversible cell cycle arrest at the G 1 phase upon induction. The aim of this study was to characterize expression patterns markers p14 ARF , p16 INK4a and p21 WAF1/Cip1 during breast progression in large patient cohort. Methods results We conducted retrospective 1080 patients with invasive ductal carcinoma, no special type, over 11‐year period. performed immunohistochemical staining on tissue microarrays...
Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 DCR2 assesses their significance on patient survival as single or combined marker with P16 P14 using breast progression series. One thousand eighty (1080) patients primary invasive ductal carcinoma, no special type, were recruited through an 11-year retrospective period. We...
Alzheimer's disease (AD) is a common amnestic cognitive impairment characterised by β-amyloid (Aβ) plaques deposit in the brain of elderly. AD yet incurable due to its unknown exact pathogenesis and unavailability effective remedies clinical application. Thymosin β4 (Tβ4) housekeeping protein that plays important role cell proliferation, migration differentiation. It has ability protect repair neurons however it still unclear involvement AD. Therefore, aim this study elucidate mechanism Tβ4...
Tissue repair and regeneration in the central nervous system (CNS) remains a serious medical problem. CNS diseases such as traumatic neurological brain injuries have high mortality disability rate, thereby bringing considerable amount of economic burden to society families. How treat has always been issue faced by neurosurgeons. The global incidence gradually increased become challenge. Thymosin β4 (Tβ4) is main G-actin variant molecule eukaryotic cells. During development CNS, Tβ4 regulates...
Abstract Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer via cross-linking FcγR on NK with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) dysfunctional Fc and failed engagement FcγRs immune cells. However, little is known about how scIgGs impact antitumor immunity in tumor microenvironment. In this study, we revealed a significant association progression poor outcomes breast patients ( n = 547). Using multiple mouse models,...
Pharmacognosy Magazine,2020,16,72,689-694.DOI:10.4103/pm.pm_121_20Published:February 2021Type:Original ArticleAuthors:Marilyn Jane Yong, Ahmad Zaidi Tani, Falah Abass Mohamed Salih, Rahmawati Pare, Rina Norgainathai, and Siat Yee Fong Author(s) affiliations:Marilyn Yong1, Tani2, Salih2, Pare2, Norgainathai3, Fong4 1 Department of Medical Education, Faculty Medicine Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, 2 Biomedical Sciences Therapeutics, 3 Community Family Medicine, 4...
17β-estradiol (17β-E 2 ) has been implicated in activating autophagy by upregulating SIRT3 expression, thereby inhibiting the senescence of vascular endothelial cells. Here, we further examined molecular mechanisms that regulate expression 17β-E -induced autophagy. Methods. RT-PCR was employed to measure PVT1, miR-31, and SIRT3. Dual-luciferase assay used determine interaction GFP-LC3 staining immunoblot analysis with antibodies against LC3 Beclin-1 conducted Cellular determined using...
Abstract The authors have requested that this preprint be removed from Research Square.