A5016969262- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Gene expression and cancer classification
- Genetic diversity and population structure
- Milk Quality and Mastitis in Dairy Cows
- Forest ecology and management
- Reproductive Physiology in Livestock
- Animal Genetics and Reproduction
- Wheat and Barley Genetics and Pathology
- Molecular Biology Techniques and Applications
- Reproductive Biology and Fertility
- Animal Behavior and Welfare Studies
- Genomics and Phylogenetic Studies
- Effects of Environmental Stressors on Livestock
- Bayesian Methods and Mixture Models
- Animal testing and alternatives
- Latin American rural development
- Agricultural and Food Production Studies
- Digestive system and related health
- Agricultural Economics and Policy
- Helminth infection and control
- Machine Learning in Bioinformatics
- Coccidia and coccidiosis research
- Sperm and Testicular Function
University of Buenos Aires
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2025
Institute of Astronomy and Space Physics
2022
Centro Científico Tecnológico - San Juan
2018-2020
Universidad de Zaragoza
2014-2019
Instituto de Genética Veterinaria
2016
Universidad Nacional de La Plata
2016
The availability of SNP chips for massive genotyping has proven to be useful genetically characterize populations domestic cattle and assess their degree divergence. In this study, the Illumina BovineHD BeadChip array was used describe genetic variability divergence among 7 important autochthonous Spanish beef breeds. within-breed diversity, measured as marker expected heterozygosity, around 0.30, similar other European analysis molecular variance revealed that 94.22% total explained by...
Genomic selection uses whole-genome marker models to predict phenotypes or genetic values for complex traits. Some of these fit interaction terms between markers, and are therefore called epistatic. The biological interpretation the corresponding fitted effects is not straightforward there threat overinterpreting their functional meaning. Here we show that predictive ability epistatic relative additive can change with density panel. In more detail, publicly available Arabidopsis rice...
The single-step covariance matrix H combines the pedigree-based relationship $${\mathbf {A}}$$ with more accurate information on realized relatedness of genotyped individuals represented by genomic {G}}$$ . In particular, to improve convergence behavior iterative approaches and reduce inflation, two weights $$\tau$$ $$\omega$$ have been introduced in definition {H}}^{-1}$$ , which blend inverse a part Since this blending is based equation describing its impact structure {H}}$$ not obvious....
The Brangus breed was developed to combine the superior characteristics of both its founder breeds, Angus and Brahman. It combines high adaptability tropical subtropical environments, disease resistance, overall hardiness Zebu cattle with reproductive potential carcass quality Angus. is known that major histocompatibility complex (MHC, also as bovine leucocyte antigen: BoLA), located on chromosome 23, encodes several genes involved in adaptive immune response may be responsible for...
Procedures for the detection of signatures selection can be classified according to source information they use reject null hypothesis absence selection. Three main groups tests identified that are based on: (1) analysis site frequency spectrum, (2) study extension linkage disequilibrium across length haplotypes surround polymorphism, and (3) differentiation among populations. The aim this was compare performance a subset these procedures by using dataset on seven Spanish autochthonous beef...
Abstract Epigenetics has become one of the major areas biological research. However, degree phenotypic variability that is explained by epigenetic processes still remains unclear. From a quantitative genetics perspective, estimation variance components achieved means information provided resemblance between relatives. In previous study, this was described as function component and reset coefficient indicates rate dissipation marks across generations. Given these assumptions, we propose...
In the two decades of continuous development genomic selection, a great variety models have been proposed to make predictions from information available in dense marker panels. Besides deciding which particular model use, practitioners also need many minor choices for those parameters are not typically estimated by data (so called "hyper-parameters"). When focus is placed on predictions, most these decisions made direction sought optimize predictive accuracy. Here we discuss and illustrate...
Summary Orthogonal Legendre polynomials ( LP ) are used to model the shape of additive genetic and permanent environmental effects in random regression models RRM ). Frequently, Akaike AIC Bayesian BIC information criteria employed select order. However, it has been theoretically shown that neither nor is simultaneously optimal terms consistency efficiency. Thus, goal was introduce a method, ‘penalizing adaptively likelihood’ PAL ), as criterion order . Four simulated data sets real (60 513...
Mixed models are commonly used for the estimation of variance components and genetic evaluation livestock populations. Some include two types additive effects, direct maternal. Estimates obtained with that account maternal effects have been subject a long-standing controversy about strong negative estimates covariance between effects. Genomic imprinting is known to be in some cases statistically confounded In this study, we analysed consequences ignoring paternally inherited on partitioning...
In organisms with sexual reproduction, genetic diversity and genome evolution are governed by meiotic recombination caused crossing-over, which is known to vary within the genome. this study, we propose a simple method estimate rate that makes use of persistency linkage disequilibrium –LD- phase among closely related populations. The biological material comprised 171 triplets (sire/dam/offspring) from seven populations autochthonous beef cattle in Spain (Asturiana de los Valles,...
The Spanish local beef cattle breeds have most likely common origin followed by a process of differentiation. This particular historical evolution has probably left detectable signatures in the genome. objective this study was to identify genomic regions associated with differentiation processes seven autochthonous populations (Asturiana de los Valles (AV), Avileña-Negra Ibérica (ANI), Bruna dels Pirineus (BP), Morucha (Mo), Pirenaica (Pi), Retinta (Re) and Rubia Gallega (RG)). BovineHD 777K...
Genomic relationships based on markers capture the actual instead of expected (based pedigree) proportion genome shared identical by descent (IBD). Several methods exist to estimate genomic relationships. In this research, we compare four such that were tested looking at empirical distribution estimated across 6704 pairs half-sibs from a cross-bred pig population. The first method multiple marker linkage analysis displayed mean and standard deviation (SD) in close agreement with ones was...
Genome inheritance is by segments of DNA rather than independent loci. We introduce the ancestral regression (AR) as a recursive system simultaneous equations, with grandparental path coefficients novel parameters. The information given pedigree in AR complementary that provided dense set genomic markers, such resulting linear function BV uncorrelated to average parental absence inbreeding. then connected segmental causal multivariate Gaussian density for BV. covariance structure (Σ)...
Summary Consider the estimation of genetic (co)variance components from a maternal animal model (MAM) using conjugated Bayesian approach. Usually, more uncertainty is expected priori on value additive variance than direct variance. However, it not possible to such differential when assuming an inverted Wishart (IW) distribution for covariance matrix. Instead, consider use generalized (GIW) distribution. The GIW essentially extension IW with larger set distinct parameters. In this study, in...
Summary This study evaluated different strategies for implementing a single‐step genomic selection programme in two autochthonous Spanish beef cattle populations (Pirenaica—Pi and Rubia Gallega— RG ). The were compared terms of accuracy attained under scenarios by simulating data over the known genealogy. Several genotyping approaches tested, as well as, other factors like marker density, effective population size, mutation rate heritability trait. results obtained showed gains with respect...
Abstract Cultivated bread wheat (Triticum aestivum L.) is an allohexaploid species resulting from the natural hybridization and chromosome doubling of allotetraploid durum (T. turgidum) a diploid goatgrass Aegilops tauschii Coss (Ae. tauschii). Synthetic hexaploid (SHW) was developed through interspecific Ae. T. turgidum, then crossed to produce synthetic derivatives (SHWDs). Owing this founding variability, one may infer that genetic variances native wild populations vs improved vary due...
Brangus is a composite cattle breed developed with the objective of combining advantages Angus and Zebuine breeds (Brahman, mainly) in tropical climates. The aim this work was to estimate composition both genome-wide locally, at chromosome level, uncover genomic regions evidencing positive selection Argentinean population/nucleus. To do so, we analysed marker data from 478 animals, including Brangus, Brahman. Average 35.0% ± 9.6% Brahman, lower than expected according theoretical fractions...
The covariance matrix of breeding values is at the heart prediction methods. Prediction can be formulated using either an "observed" or a theoretical matrix, and major argument for choosing one other reduction computational burden inverting such matrix. In this regard, matrices that are derived from Markov causal models possess properties deliver sparse inverses.By models, we express value individual as linear regression on ancestral values, plus residual term, which call (RBV). latter noise...