A5080669413- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- Metabolomics and Mass Spectrometry Studies
- Cancer Cells and Metastasis
- Reproductive Biology and Fertility
- Bone Tissue Engineering Materials
- Reproductive Physiology in Livestock
- Intraoperative Neuromonitoring and Anesthetic Effects
- Gynecological conditions and treatments
- Pregnancy and preeclampsia studies
- PARP inhibition in cancer therapy
- Cancer Treatment and Pharmacology
- Menopause: Health Impacts and Treatments
- Glutathione Transferases and Polymorphisms
- Cancer Mechanisms and Therapy
Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology
2004-2024
Federal Almazov North-West Medical Research Centre
2024
Ministry of Health of the Russian Federation
2023-2024
Kyiv City Clinical Oncology Center
2011
Medical Radiological Research Center
2005
Ovarian cancer ascites is a native medium for cells that allows investigation of their secretome in natural environment. This interest as promising source potential biomarkers, and also cell–cell communication. The aim this study was to elucidate specific features the malignant metabolome proteome. In order omit components systemic response formation, we compared with cirrhosis ascites. Metabolome analysis revealed 41 differed significantly between Most identified cancer-specific metabolites...
There is an urgent need for more novel and efficacious therapeutic agents strategies the treatment of ovarian cancer - one most formidable female malignancies. These approaches should be based on comprehensive understanding pathobiology this focused decreasing its recurrence metastasis. The aim study was to evaluate efficacy five-year maintenance therapy with indole-3-carbinol (I3C) as well I3C epigallocatechin-3-gallate (EGCG) conducted before, during, after combined compared alone in...
Aim. To present the literature data and clinical experience of gynecologic oncology department Russian Scientific Center Roentgen Radiology, illustrating difficulties in differential diagnosis benign malignant ovarian neoplasms associated with endometriosis. Key points. Significant gynecology oncogynecology are caused timely choice treatment tactics for neoplasms. This problem is by lack pathognomonic manifestations, low specificity limited availability diagnostic methods. Their high...
Background. A clear relationship is now found between the activity of estrogen metabolites and development tumors in estrogen-dependent tissues. Many international Russian studies could identify a number compounds involved regulation metabolites. Indole-3-carbinol one these that correct ratio 2-hydroxyestrone (2-OHE1) to 16-OHE1. It phytonutrient contained Cruciferous vegetables has antitumor activity. Our investigations used highly purified indole-3-carbinol (Indinol). The ability role...
<h3></h3> Тамоксифен, селективный модулятор рецепторов эстрогена (SERM), используется для адъювантной терапии при раке молочной железы (РМЖ). Однако он также может действовать как агонист проэстрогена в среде с низким содержанием эстрадиола. Свойства агониста влияют на эндометрий более чем у половины пролеченных пациенток. Ультразвуковой мониторинг является ведущим неинвазивным методом первичной диагностики состояния эндометрия пациенток, получающих антиэстрогенную терапию пери- и...
In spite of all modern medicine»s advances, ovarian cancer (OC) mortality remains to be incommensurably high and hold the lead among gynecological cancers. The initial cause this deplorable statistics is absence a clear concept pathogenesis OC hence justified prevention methodology early diagnosis disease; in connection, therapy that proves ineffective frequently used by medical oncologists their daily practice. As consequence, there proportion its further progression: rates late recurrences...
Abstract Aim. Evaluation of cytokine profile in cervical mucus patients with different degrees intraepithelial neoplasia (CIN). Design. One-central prospective open cohort incomed intervention study Materials and methods. Thirty female aged 18 to 49 years were included the study. The control group (А) consisted 10 HPV-negative without pathology. Group B low grade squamous cell lesion cervix (LSIL). C high (HSIL). Cervical was collected from all participants determine levels various...
BACKGROUND: In recent decades, the incidence of cervical adenocarcinomas has increased from 5% to 20%. Endocervical are characterized by a more aggressive course and early metastasis. Owing difficulties in cytological diagnosis adenocarcinoma, radiation diagnostics staging subsequently play key role. Very few studies have examined use magnetic resonance imaging diagnosing adenocarcinomas. AIM: To determine diagnostic informativeness according T-criterion assessing depth tumor invasion into...
Objective. To perform macroscopic and histological analysis of the vascular wall after implantation a self-expanding nitinol stent in vivo experiment. Material methods. 2 Danish Landrace pigs were selected for experimental new with an oversizing 5–20%. Vital signs assessed both throughout observation period. In postoperative period, animals received dual antiplatelet therapy 3 months. After months, underwent control angiography ultrasound examination iliofemoral segment, followed by...
Ovarian cancer (OC) is a heterogenous disease in terms of genetic mutations and tumor phenotypes can be divided into I II types. Type high grade tumors are more common, accompanied by ascites, the main cause cancer-related death women. OC associated ascites considered as valuable source material containing wide range dissolved components cell populations. Over past decades, cellular acellular have been studied, but its effect on chemoresistance development metastasis continues to studied....
Objective of the Review: To present advantages and disadvantages LAE SLN biopsy to discuss possibility using in all patients with early endometrial cancer. Key Points. For years, lymphadenectomy (LAE) has been a standard procedure which allowed determining extent neoplastic process therapy cancer (EC). However, this is very traumatic; besides, it does not impact overall disease-free survival associated negative postoperative consequences. Introduction sentinel lymph node (SLN) made possible...
The viral nature of many female genital cancers is now beyond question. By taking into account this fact, the problem qualitative assessment ofthenatureofcervicalintraepithelialneoplasia(CIN)anditsfocusonprogressiontoinvasivecarcinomabecomesquitenatu ral.Studiesof a number biological markers carcinogenesis have recently provided possibility for prospective prediction. paper con siders as- pects importance molecular proliferation and apoptosis in etiopathogenesis cancers. It gives results...
The study included patients observed and treated in Russian scientific centre of roentgenradiology Ministry Health Federation the period from 1999 to 2010 (n = 405): including 111 postmenopausal women who are without anamnestic data on presence cancer at any site, group with gynecological postmenopause 60 endometrial cancer, 67 malignant epithelial ovarian tumors, 87 observations cervical 80 vulva cancer. average age was 58.6 ± 0.4 years. bone mineral density, body mass index level estrogen...
Goals:The number of elderly breast cancer (BC) patients in Ukraine as well the Western world has increased.The data on biological characteristics and clinical behavior BC are limited.The aim study is features patients.Methods: The clinical, morphological immunohistochemical methods statistical analysis were used study.65 divided into two groups: aged 65 years older (Group I -30 pts) 50-55 II -35 pts).The following parameters evaluated: tumor size, histology tumor, lymph nodes with...
The article offers the latest view on possibilities of diagnostic algorithm to identify vaginal cancer (VC), rare tumor woman’s reproductive system. is described as a consensus leading expert in imaging diagnostics, well oncogynecologysts, investigating challenges and therapies. sets forth principal trends using methods, their role for staging VC, planning assessing efficacy applied therapy, on-going surveillance over patients, who have undergone specialized anti-cancer treatment
Objective of the Review: To analyze levels cytokines measurement as potential method for early detection cervical dysplasia progression. Key points. The authors analyzed abstracts and full-text articles published in Pubmed, UpToDate, Embase Cochrane Library period from 1999 to 2022. Detection different biological fluids have been already used widespread additional prognostic factor malignances localization. Expression co-expression mucus could be also useful potentially dangerous forms with...