A5068849123- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
Sapienza University of Rome
2023-2025
Ischemic stroke is one of the leading causes mortality and long-term disability worldwide, emphasizing need for rapid effective acute management. Revascularization therapies are critical to this strategy, demanding swift intervention. Intravenous thrombolysis (IVT) with alteplase (ALT) was traditionally recommended within 4.5 h from symptom onset ischemic (AIS) patients. However, landmark studies, such as ECASS IV, EXTEND, EPITHET have demonstrated that IVT may be extended up 9 in select...
Good leptomeningeal collaterals (LMC) after large vessel occlusion (LVO) extend the time window for endovascular therapy. The mechanisms regulating LMC activation are not fully understood. aim of this study was to investigate potential role two vasoactive molecules Endothelin-1 (ET1) – vasoconstrictor agent - and nitric oxide (NO) vasodilator in regulation post-stroke LMC. Ischemic stroke patients within 6 hours LVO were included. Collateral status assessed using Menon scoring system based...
Good leptomeningeal collaterals (LMCs) after large vessel occlusion (LVO) extend the time window for endovascular therapy. The mechanisms regulating LMC activation are not fully understood. aim of this study was to investigate potential role two vasoactive molecules endothelin-1 (ET-1)—a vasoconstrictor agent—and nitric oxide (NO)—a vasodilator agent—in regulation post-stroke LMCs. Ischemic stroke patients within 6 h LVO were included. Collateral status assessed using Menon scoring system...
Background and purpose Acute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims this study were to compare clinical/radiological characteristics, endothelial coagulation dysfunction between acute patients with without COVID-19 investigate if how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation. Methods We enrolled AIS within 12 h from onset compared them an age- sex-matched cohort controls COVID-19. Neuroimaging...
Abstract Background and aims Perihematomal hypoperfusion may lead to ischemic damage during intraparenchymal cerebral hemorrhage (ICH), resulting in worse prognosis. We aimed (1) investigate the relationship between serum biomarkers related oxidative stress vasoactive substances occurrence of perihematomal lesions ICH, (2) evaluate their correlation with volumetric evolution hematoma edema. Methods enrolled 28 patients affected by ICH. Blood samples were collected at timepoint T0 (admission...
Perihematomal hypoperfusion may lead to ischemic damage during intraparenchymal cerebral hemorrhage (ICH), resulting in worse prognosis. We aimed (1) investigate the relationship between serum biomarkers related oxidative stress and vasoactive substances occurrence of perihematomal lesions ICH (2) evaluate their correlation with volumetric evolution hematoma edema. enrolled 28 patients affected by ICH. Blood samples were collected at three different time points from symptom onset: T0, T1, T2...