A5053133411- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Chromatin Remodeling and Cancer
Medical College of Wisconsin
2025
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2019-2022
Ospedale Maggiore
2019-2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019
is a recurrently mutated gene in chronic lymphocytic leukemia (CLL) but the functional implications of
Summary Richter syndrome (RS) is mostly due to the direct transformation of chronic lymphocytic leukaemia (CLL) clone, as documented by same immunoglobulin heavy‐chain variable region (IGHV) rearrangement in both CLL and RS cells. In rare cases characterized a better outcome, clone harbours different IGHV compared phase. We investigated phase clonally unrelated test whether was already identifiable prior clinicopathologic transformation, albeit undetectable conventional approaches. cells...
Abstract Background: Small Cell Lung Cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by epigenetic dysregulation. EZH2, a key component of the Polycomb Repressive Complex 2 (PRC2), overexpressed in SCLC and correlates with poor prognosis. Recent studies show that EZH2 inhibition enhances cell immunogenicity, though underlying mechanisms remain unclear. Aim: This study investigates how function alters landscape using integrated multi-omics approach. In lines treated...
Summary We aimed at molecularly dissecting the anatomical heterogeneity of small lymphocytic lymphoma (SLL), by analysing a cohort 12 patients for whom paired DNA from lymph node biopsy and circulating cells, as well plasma‐circulating tumour (ctDNA) was available. Notably, analyses cells complement each other since fraction mutations (20·4% 36·4%, respectively) are unique to compartment. Plasma ctDNA identified two additional mutations. Consistently, different synchronous sources in...
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Background: Small lymphocytic lymphoma (SLL) is a model that can inform on whether spatial heterogeneity exists in leukemic B-cell tumors, as it the sole entity markedly involves both blood and lymph nodes all cases. Circulating tumor DNA (ctDNA) recapitulates disease genetics aggressive lymphomas but its role advantage multiregional sequencing of peripheral node biopsy unexplored. Methods: Patients with SLL (n = 12) were referred to our institution provided with: i) tumour gDNA extracted...