A5080693109- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Analytical Chemistry and Chromatography
- Immunotherapy and Immune Responses
- Metabolomics and Mass Spectrometry Studies
- Electrocatalysts for Energy Conversion
- Electrochemical Analysis and Applications
- Spectroscopy and Chemometric Analyses
- Free Radicals and Antioxidants
- Electrochemical sensors and biosensors
- Advanced Biosensing Techniques and Applications
- Plant biochemistry and biosynthesis
- Biosensors and Analytical Detection
- Copper-based nanomaterials and applications
- Metal complexes synthesis and properties
- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Protein Interaction Studies and Fluorescence Analysis
- Photosynthetic Processes and Mechanisms
- Garlic and Onion Studies
- Advanced Proteomics Techniques and Applications
- Computational Drug Discovery Methods
Yale University
2025
Australian Regenerative Medicine Institute
2023-2024
Monash University
2023-2024
Institute for Advanced Studies in Basic Sciences
2014-2019
University of Zanjan
2015-2016
Abstract The major histocompatibility complex (MHC) encodes a range of immune response genes, including the human leukocyte antigens (HLAs) in humans. These molecules bind peptide and present them on cell surface for T recognition. repertoires peptides presented by HLA are termed immunopeptidomes. highly polymorphic nature genres that encode confers allotype-specific differences sequences bound ligands. Allotype-specific ligand preferences often defined peptide-binding motifs. Individuals...
<title>Abstract</title> The major histocompatibility complex (MHC) encodes molecules that present peptides on the surface of cells to stimulate T-cell-mediated immune responses. stability peptide-MHC class I complexes (pMHCI) has been postulated influence immunogenicity virus-derived epitopes and cancer neoepitopes. Here, we sought investigate this further by conducting thermostability profiling thousands individual pMHCI, including a panel 110 vaccinia virus (VACV) derived with known...
Immunopeptidomics has made tremendous contributions to our understanding of antigen processing and presentation, by identifying quantifying antigenic peptides presented on the cell surface Major Histocompatibility Complex (MHC) molecules. Large complex immunopeptidomics datasets can now be routinely generated using Liquid Chromatography-Mass Spectrometry techniques. The analysis this data - often consisting multiple replicates/conditions rarely follows a standard pipeline, hindering...
Human leukocyte antigen (HLA) molecules play a crucial role in directing adaptive immune responses based on the nature of their peptide ligands, collectively coined immunopeptidome. As such, study HLA has been major interest development cancer immunotherapies such as vaccines and T-cell therapies. Hence, comprehensive understanding profiling immunopeptidome is required to foster growth these personalised solutions. We herein describe SAPrIm, an Immunopeptidomics tool for Mid-Throughput era....
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell immunity against current and emerging SARS-CoV-2 variants. Precise identification of conserved epitopes is critical designing effective vaccines. Here we introduce a comprehensive computational framework incorporating machine learning algorithm—MHCvalidator—to enhance mass spectrometry-based immunopeptidomics sensitivity. MHCvalidator identifies unique presented by the B7 supertype, including an...
Colorectal cancer (CRC) ranks high in both men and women, accounting for about 13% of all cancers. In this study, a novel pattern recognition strategy is proposed to improve early diagnosis CRC through visualizing the relationship between different spectral patterns case-control research. Partial least squares-discriminant analysis (PLS-DA) supervised Kohonen network (SKN) were used classify fluorescence excitation-emission matrices (EEMs) from 289 human blood plasma samples containing...
Interactions of Isatin and its derivatives, Isatin-3-isonicotinylhydrazone (IINH) Isatin-β-thiosemicarbazone (IBT), with calf thymus DNA (ctDNA) have been investigated to delineate pharmaceutical-physicochemical properties using UV-Vis/fluorescence/circular dichroism (CD) spectroscopy, viscosity measurements, multivariate chemometrics. IINH IBT molecules intercalate between base pairs DNA, hypochromism in UV absorptions, increase the CD positive band, sharp specific viscosity, displacement...
The dielectric constant is a key physicochemical property in solubility, chemical equilibrium and the synthesis of compounds pharmaceutical/chemical sciences. In this context, quantitative structure–property relationship (QSPR) model was designed from 3207 binary solvent mixtures by using 23 calculated experimental–theoretical descriptors including fractions (f1 f2), individual constants solvents (dc1 dc2), temperature, Abraham Hansen solvation parameters. QSPR developed genetic algorithm...
Coronary artery disease (CAD), one of the most common fatal diseases in world, was examined<italic>via</italic>investigation the<sup>1</sup>H-NMR spectra human blood plasma and clinical laboratory parameters with aim early diagnosis.