A5013750549- Hepatitis C virus research
- Immune Cell Function and Interaction
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Toxin Mechanisms and Immunotoxins
- Diabetes Treatment and Management
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- CAR-T cell therapy research
- Chromium effects and bioremediation
- Mosquito-borne diseases and control
- Virus-based gene therapy research
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Immune responses and vaccinations
- Hepatitis B Virus Studies
- Natural Antidiabetic Agents Studies
- Biochemical Acid Research Studies
- Vitamin D Research Studies
- Viral Infections and Vectors
- Innovations in Medical Education
- COVID-19 Clinical Research Studies
University of Exeter
2025
Peninsula Health
2005-2016
Symbiosis Group
2016
Symbiosis International University
2016
Peninsula College of Medicine and Dentistry
2005-2016
Most people with hepatitis C virus (HCV) develop chronic infection persistent viremia. Resolution of is associated antiviral cellular immune responses T helper 1 (Th1) type. Interleukin-12 (IL-12) a key cytokine in the generation Th1 responses, and functionally relevant polymorphisms IL12B gene its promoter have been described recently. We sought an association between three outcome HCV 195 antibody-positive patients; 123 were chronically infected detectable RNA, 72 had spontaneously...
Summary Cellular immunity with interferon gamma production could have a role in protection from hepatitis C virus (HCV). Interleukin (IL)-12 is key cytokine promoting such anti-viral T helper 1 (Th1) responses. We hypothesized that genetic background able to promote cellular responses may be associated apparent infection and investigated the distribution of functional 1188A/C polymorphism IL-12B HCV exposed but uninfected cases. The frequency high IL-12-producing allele was determined by...
Several cell surface molecules have hepatitis C virus (HCV) binding properties and may serve as receptors facilitating viral entry into cells. The large extracellular loop (LEL) of CD81 has been shown to bind the HCV envelope protein E2 with several critical residues for CD81‐HCV‐E2 interaction. It was hypothesised that variation in LEL sequence modify susceptibility infection. RNA negative patients spontaneous clearance (RNA −ve); positive cases, who are affected chronically +ve); at high...
Hepatitis C virus (HCV) is a pathogen causing chronic hepatitis, cirrhosis, and liver cancer occurring in about 3% of the world's population. Most individuals infected with HCV develop persistent viremia. Oxidative stress may play an important role pathogenesis number diseases including infection diabetes mellitus. Polymorphisms antioxidant genes determine cellular oxidative levels as primary pathogenic and/or its complications. Patients normal, healthy controls were investigated for...
Diabetes is a heterogeneous disease where many factors are involved in its pathogenesis. The genotype frequency of Catalase (CAT) microsatellite polymorphism patients with Type 1-Diabetes (T1DM) was analysed.
HCV is a major cause of liver disease worldwide. IL-12 plays an essential role in the balance T helper 1 (Th1) differentiation versus 2 (Th2) driven response from its naïve precursor. Linkage disequilibrium measures degree to which alleles at two loci are associated and non-random associations between loci. Haplotypes three IL-12B studied were determined patient cases normal healthy control subjects. The frequency 12 possible haplotypes on 3 was subjects heterozygous only one within...
TALEs targeting a promoter sequence and fused with transcription activation domain (TAD) may be used to specifically induce the expression of gene as potential treatment for haploinsufficiency. This therapeutic approach was applied increase frataxin in fibroblasts Friedreich ataxia (FRDA) patients. FRDA fibroblast cells were nucleofected pCR3.1 vector coding TALEFrat#8 VP64. A twofold mRNA (detected by quantitative reverse transcription-PCR (qRT-PCR)) associated similar mature form protein...
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COVID-19 is caused by a Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) and has two spike subunits on the envelope of SARS-CoV-2, S1 S2, where binds to Angiotensin Converting Enzyme (ACE-2), receptor host cells S2 cell surface membrane. Different immune responses virus are apparent, from asymptomatic severe respiratory distress, organ failure ultimately death. Immune without hyper-inflammation essential successful viral resolution. Pathological environmental factors drive...