A5006171928- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- Cellular transport and secretion
Université Jean Monnet
2022-2023
Centre International de Recherche en Infectiologie
2022-2023
Inserm
2022-2023
Université Claude Bernard Lyon 1
2022-2023
École Normale Supérieure de Lyon
2022-2023
Centre National de la Recherche Scientifique
2022-2023
Abstract Transcriptional cofactors YAP/TAZ have recently been found to support autophagy and inflammation, which are part of cell-autonomous immunity critical in antibacterial defense. Here, we studied the role YAP against Staphylococcus aureus using CRISPR/Cas9-mutated HEK293 cells a primary cell-based organoid model. We that S. infection increases transcriptional activity, is required reduce intracellular replication. A 770-gene targeted transcriptomic analysis revealed upregulates genes...
Previously considered as an exclusive extracellular bacterium, Staphylococcus aureus has been shown to be able invade many cells in vitro and humans. Once inside the host cell, both cytosolic endosome-associated S. strongly induce macroautophagy/autophagy. Whether autophagy fosters intracellular survival or clearance remains unclear. The YAP1-TEAD axis regulates expression of target genes controlling cell fate (e.g., proliferation, migration, cycle …). Growing evidence indicates that also...