A5050905987- Neuroscience and Neuropharmacology Research
- Extracellular vesicles in disease
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Receptor Mechanisms and Signaling
- HIV-related health complications and treatments
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Immune cells in cancer
- Nicotinic Acetylcholine Receptors Study
- Eicosanoids and Hypertension Pharmacology
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Lipid metabolism and biosynthesis
- Polyamine Metabolism and Applications
- Molecular Sensors and Ion Detection
- Polymer Surface Interaction Studies
- Endoplasmic Reticulum Stress and Disease
- FOXO transcription factor regulation
- Protein Kinase Regulation and GTPase Signaling
- Nanoparticles: synthesis and applications
- Enzyme Structure and Function
Inserm
2024
Laboratoire CarMeN
2024
Hospices Civils de Lyon
2024
Université Claude Bernard Lyon 1
2024
Sapienza University of Rome
2022-2024
University of Salento
2023
Aptuit (Italy)
2014-2022
University of Bologna
1989-2012
GlaxoSmithKline (Italy)
2001
Abstract Background Macrophages release not only cytokines but also extracellular vesicles (EVs). which are small membrane-derived nanovesicles with virus-like properties transferring cellular material between cells. Until now, the consequences of macrophage plasticity on and composition EVs have been poorly explored. In this study, we determined impact high-glucose (HG) concentrations metabolism, characterized their derived-EV subpopulations. Finally, whether HG-treated macrophage-derived...
Abstract Living photovoltaics are microbial electrochemical devices that use whole cell–electrode interactions to convert solar energy electricity. The bottleneck in these technologies is the limited electron transfer between microbe and electrode surface. This study focuses on enhancing this by engineering a polydopamine (PDA) coating outer membrane of photosynthetic Synechocystis sp. PCC6803. provides conductive nanoparticle shell increase adhesion improve charge extraction. A combination...
Abstract Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD a transgenic mouse model—to investigate T14, 14mer peptide, as key signaling molecule the neuropathology. Results T14 increases AD brains progresses conspicuous 5XFAD mice, where its immunoreactivity corresponds to that seen AD: neurons immunoreactive for...
The polarization of tissue-resident macrophages is influenced by a variety signals from the immune system and local tissue environment, including nutrition. Although it known that quality quantity ingested lipids have significant effect on lipid composition extracellular vesicles their fate, unknown how nutritional environment modifies release function macrophage-derived EVs. In this study, we used combination palmitate oleate (1:2, FFA) to generate lipid-associated TREM2-expressing...
Six Gram-positive-staining, microaerophilic, non-spore-forming, fructose-6-phosphate phosphoketolase-positive bacterial strains with a peculiar morphology were isolated from faecal samples of baby common marmosets (Callithrix jacchus). Cells these showed not reported previously for bifidobacterial species, which resembled coiled snake, always or ring shaped forming 'Y' shape. Strains MRM 3/1(T) and 4/2 chosen as representative characterized further. The bacteria utilized wide range...
Lipotoxicity refers to the harmful effects of excess fatty acids on metabolic health, and it can vary depending type involved. Saturated unsaturated exhibit distinct effects, though precise mechanisms behind these differences remain unclear. Here, we investigated lipotoxicity palmitic acid (PA), a saturated acid, compared with oleic (OA), monounsaturated in hepatic cell line HuH7.Our results demonstrated that PA, unlike OA, induces lipotoxicity, endoplasmic reticulum (ER) stress, autophagy...
1. The regional binding of [3H]-(+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d)cyclohepten-5,10-imine maleate ([3H]-(+)-MK 801) to sections rat brain was measured by an in vitro quantitative autoradiographic technique. A heterogeneous distribution sites observed. 2. High values were detected the hippocampal formation and cerebral cortex, while very low found cerebellum. [3H]-(+)-MK 801 not detectable white matter tracts or stem. 3. inhibited increasing concentrations both 7-chlorokynurenate...
Hepatic fibrosis (HF) is a major cause of liver-related disorders and together with cancer-associated fibroblasts can favor liver cancer development by modulating the tumor microenvironment. Advanced HF, characterized an excess extracellular matrix (ECM), mediated TGF- β1, that activates hepatic stellate cells (HSCs) fibroblasts. A TGF-β1 receptor inhibitor, LY2157299 or Galunisertib (GLY), has shown promising results against chronic progression in animal models, we show it be further...
A Spray Drying process is presented for one-step production of nanostructured microsponges from TEMPO oxidized cellulose nanofibers (TOCNF). Different formulations were prepared by varying both the oxidation degree and relative ratio branched polyethyleneimine citric acid, introduced as cross-linkers. The best reaction conditions achieved with TOCNF bearing highest content carboxylic groups (1.5 mmolCOOH/gTOCNF), providing micro-particles an average diameter below 5 mm, a good colloidal...
ABSTRACT Background Macrophages release not only cytokines but also extracellular vesicles (EVs). EVs are small lipid-derived with virus-like properties transferring lipids, RNA and proteins between cells. Until now, the consequences of macrophage plasticity on composition have been poorly explored. In this study, we determined impact high-glucose (HG) concentrations metabolism, characterized their derived EV subpopulations. Finally, whether HG-treated macrophage-derived participate in...