A5012801677- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Advanced NMR Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Quantum, superfluid, helium dynamics
- Nuclear Physics and Applications
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Ultrasound in Clinical Applications
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Thermal Regulation in Medicine
- Pulmonary Hypertension Research and Treatments
- Respiratory viral infections research
- Transplantation: Methods and Outcomes
- Medical Imaging and Pathology Studies
- Cardiovascular Health and Disease Prevention
- Obstructive Sleep Apnea Research
- Congenital Diaphragmatic Hernia Studies
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
Medizinische Hochschule Hannover
2017-2025
German Center for Lung Research
2017-2025
Purpose In this feasibility study, a phase‐resolved functional lung imaging postprocessing method for extraction of dynamic perfusion (Q) and ventilation (V) parameters using conventional 1H MRI Fourier decomposition acquisition is introduced. Methods Time series coronal gradient‐echo MR images with temporal resolution 288 to 324 ms two healthy volunteers, one patient chronic thromboembolic hypertension, cystic fibrosis, obstructive pulmonary disease were acquired at 1.5 T. Using sine model...
Purpose To assess the feasibility of monitoring effects elexacaftor-tezacaftor-ivacaftor (ETI) therapy on lung ventilation and perfusion in people with cystic fibrosis (CF), using phase-resolved functional (PREFUL) MRI. Materials Methods This secondary analysis a multicenter prospective study was carried out between August 2020 March 2021 included participants 12 years or older CF who underwent PREFUL MRI, spirometry, sweat chloride test, clearance index assessment before 8–16 weeks after...
Abstract Purpose Pulmonary MRI faces challenges due to low proton density, rapid transverse magnetization decay, and cardiac respiratory motion. The fermat‐looped orthogonally encoded trajectories (FLORET) sequence addresses these issues with high sampling efficiency, strong signal, motion robustness, but has not yet been applied phase‐resolved functional lung (PREFUL) MRI—a contrast‐free method for assessing pulmonary ventilation during free breathing. This study aims develop a...
Background Perfusion‐weighted (Qw) noncontrast‐enhanced proton lung MRI is a promising technique for assessment of pulmonary perfusion, but still requires validation. Purpose To improve perfusion‐weighted phase‐resolved functional (PREFUL)‐MRI, to validate PREFUL with perfusion single photon emission computed tomography (SPECT) as gold standard, and compare dynamic contrast‐enhanced (DCE)‐MRI reference. Study Type Retrospective. Population Twenty patients chronic obstructive disease (COPD),...
Purpose To test the feasibility of 3D phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease, to compare 2D PREFUL, investigate required temporal resolution obtain stable PREFUL measurement. Methods Sixteen participants underwent using PREFUL. Retrospectively, spatial (4 × 4 mm 3 ) was decreased match 15 ), abbreviated as lowres . In addition regional ventilation (RVent), flow‐volume loops were computed rated by a cross‐correlation (CC)....
To test the feasibility of regional fully quantitative ventilation measurement in free breathing derived by phase-resolved functional lung (PREFUL) MRI supine and prone positions. In addition, influence T2 * relaxation time on quantification is assessed.Twelve healthy volunteers underwent at 1.5 T using a 2D triple-echo spoiled gradient echo sequence allowing for time. Minute (ΔV) was quantified conventional fractional (FV) newly introduced (VR), which corrects volume errors due to image...
Background Free‐breathing phase‐resolved functional lung (PREFUL)‐MRI may be useful for treatment monitoring in chronic obstructive pulmonary disease (COPD) patients with dyspnea. PREFUL test–retest reliability is essential clinical application. Purpose To measure the repeatability of PREFUL‐MRI ventilation (V) and perfusion (Q) parameters. Study Type Retrospective prospective. Population A total 28 COPD 57 healthy subjects. Field Strength/Sequence 1. 5T MRI / 2D spoiled gradient echo...
To assess whether dynamic ventilation and perfusion (Q) biomarkers derived by phase-resolved functional lung (PREFUL) MRI can measure treatment response to 14-day therapy with indacaterol-glycopyrronium (IND-GLY) correlate clinical outcomes including function, symptoms, cardiac function in patients chronic obstructive pulmonary disease (COPD), as determined spirometry, body plethysmography, MRI, dyspnea score measurements.The left ventricular COPD (CLAIM) study enrolled aged 40 years or...
Background Non‐contrast‐enhanced 1 H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional ventilation but a comparison direct measurement using 19 F MRI is lacking. Purpose To compare parameters calculated 3D phase‐resolved functional (PREFUL) MRI. Study Type Prospective. Population Fifteen patients asthma, 14 chronic obstructive disease, and 13 healthy volunteers. Field Strength/Sequence A gradient‐echo pulse sequence golden‐angle increment...
Background Regional flow volume loop ventilation‐weighted noncontrast‐enhanced proton lung MRI in free breathing has emerged as a novel technique for assessment of regional ventilation, but yet not been validated with 129 Xenon ( Xe‐MRI), direct visualization ventilation healthy volunteers, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD) patients. Purpose To compare loops measured by phase‐resolved functional (PREFUL‐MRI) Xe‐MRI imaging function test parameters. Study...
For sensitive diagnosis and monitoring of pulmonary disease, ionizing radiation-free imaging methods are great importance. A noncontrast free-breathing proton magnetic resonance (MRI) technique for assessment perfusion is phase-resolved functional lung (PREFUL) MRI. Since there no validation PREFUL MRI across different centers scanners, the purpose this study was to compare perfusion-weighted with well-established dynamic contrast-enhanced (DCE) two on scanners from vendors. Sixteen patients...
Background Chronic lung allograft dysfunction (CLAD), the physiologic correlate of chronic rejection, remains a major barrier to long-term survival following transplant. Biomarkers for early prediction future transplant loss or death due CLAD might open window opportunity diagnosis and treatment CLAD. Purpose To evaluate prognostic use phase-resolved functional (PREFUL) MRI in predicting CLAD-related death. Materials Methods In this prospective, longitudinal, single-center study, PREFUL...
Abstract Objectives To investigate whether 3D phase-resolved functional lung (PREFUL)-MRI parameters are suitable to measure response elexacaftor/tezacaftor/ivacaftor (ETI) therapy and their association with clinical outcomes in cystic fibrosis (CF) patients. Methods Twenty-three patients CF (mean age: 21; age range: 14–46) underwent MRI examination at baseline 8–16 weeks after initiation of ETI. Morphological PREFUL scans assessed pulmonary ventilation. images were evaluated using a...
Abstract Purpose Various parameters of regional lung ventilation can be estimated using phase‐resolved functional (PREFUL)‐MRI. The parameter “ventilation correlation coefficient (Vent‐CC)” was shown advantageous because it assesses the dynamics air flow. Calculating Vent‐CC depends on a voxel‐wise comparison to healthy reference flow curve. This work examines effect placing region interest (ROI) in various quadrants or different coronal slices. Furthermore, algorithms for automated ROI...
Abstract Objectives 3D phase-resolved functional lung (PREFUL) MRI offers evaluation of pulmonary ventilation without inhalation contrast agent. This study seeks to compare maps obtained from PREFUL with a direct measurement derived 129 Xe in both patients chronic obstructive disease (COPD) and healthy volunteers. Methods Thirty-one COPD 12 controls underwent free-breathing breath-hold at 1.5 T. For techniques, defect (VD) were determined respective percentage (VDP) values computed. All...
Background High ventilation (VE)-CO 2 output (VCO ), signaling increased wasted in the physiological dead space (VD phys has a dominant role eliciting activity-related dyspnoea subjects with chronic obstructive pulmonary disease (COPD) showing only mild airflow obstruction. Exposing mechanisms driving is key to advancing field towards new therapeutic approaches improve and exercise tolerance this growing patient sub-population. Study's central hypothesis Increased areas of high alveolar...
Phase-resolved functional lung MRI–derived parameters depicted pulmonary perfusion abnormalities in children and adolescents with post–COVID-19 condition correlated heart rate chronic fatigue severity.
To evaluate the reproducibility and regional variation of parameters obtained from localized 129 Xe chemical shift saturation recovery (CSSR) MR spectroscopy in healthy volunteers patients with chronic obstructive pulmonary disease (COPD) to compare results dissolved-phase imaging.Thirteen 10 COPD were scanned twice using imaging, CSSR, ventilation imaging sequences. A 16-channel phased-array coil combination regularized spectral localization achieved by sensitivity heterogeneity (SPLASH)...
Background A previous study has demonstrated the feasibility of 3D phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease. Before clinical use, repeatability ventilation parameters derived from PREFUL must be determined. Purpose To evaluate to compare testing (PFT). Study Type Prospective. Population Fifty‐three subjects 13 obstructive disease (COPD). Field Strength/Sequence prototype stack‐of‐stars spoiled‐gradient‐echo sequence at 1.5...
Pulse wave velocity (PWV) in the pulmonary arteries (PA) is a marker of vascular stiffening. Currently, only phase-contrast (PC) MRI-based options exist to measure PA-PWV.
Background The translation of phase‐resolved functional lung (PREFUL)‐MRI to routine practice in monitoring chronic thromboembolic pulmonary hypertension (CTEPH) still requires clinical corresponding imaging biomarkers vascular disease. Purpose To evaluate successful endarterectomy (PEA) via PREFUL‐MRI with pulse wave transit time (pPTT). Study Type Retrospective. Population Thirty CTEPH patients and 12 healthy controls were included. Field Strength/Sequence For a 2D spoiled gradient echo...
Contrast-free lung MRI based on Fourier decomposition is an attractive method to monitor various diseases. However, the accuracy of current perfusion quantification limited. In this study, a new approach for voxel-wise proton density and median signal decay toward steady state decomposition-based techniques proposed called QQuantified (QQuant ).Twenty patients with chronic obstructive pulmonary disease 18 thromboembolic hypertension received phase-resolved functional lung-MRI (PREFUL)...
To investigate potential presence and resolution of longer-term pulmonary diffusion limitation microvascular perfusion impairment in COVID-19 convalescents.